Aqueous self-assembly of amphiphilic nanocrystallo-polymers and their surface-active properties

HER2/neu Antibody Conjugated Poly(amino acid)-Coated Iron Oxide Nanoparticles for Breast Cancer MR Imaging

“…The as-synthesized nanoparticles were dispersible and stable only in organic solvents, such as hexane and tetrahydrofuran (THF), because of the presence of oleate/oleylamine, a hydrophobic ligand. Recently, our group reported the aqueous self-assembly of nanocrystallo polymers composed of hydrophobic gold (or iron oxide nanocrystals) and a hydrophilic PHEA backbone. , In addition, various nanostructures, such as spherical aggregates, core−shell unimolecular micelles, and cylinders, were synthesized by dodecyl chain-grafted PHEAs with different DS values (DSc 12 ), respectively …”

“…First, PHEA- g -C 18 -C 11 COOH-(EO) 2 NH 2 (74 mg, 0.37 mmol) and Fe 3 O 4 nanoparticles (24 mg, 5.01 nmol) were dissolved in 3 mL of a mixed solvent (THF [tetrahydrofuran]/DMAc [dimethylacetamide] = 4:1, v/v). , The solution was constantly stirred for 24 h to facilitate coordinate bonding between the nanoparticles and PHEA- g -C 18 -C 11 COOH-(EO) 2 NH 2 , and the nanoparticles were collected by centrifugation (7000 rpm, 30 min, Hanil science Industrial Co., Ltd, Korea) to remove unreacted PHEA- g -C 18 -C 11 COOH-(EO) 2 NH 2 . The precipitated nanoparticles were redispersed in DDI water and sonicated in a sonication bath at 25 °C to facilitate a hydrophobic interaction between nanoparticles and PHEA- g -C 18 -C 11 COOH-(EO) 2 NH 2 .…”

Poly(amino acid)-coated iron oxide nanoparticles as ultra-small magnetic resonance probes

“…Thus, biocompatible PHEA-g-C 18 -C 8 COOH can easily bind to the nanoparticle surface using both coordinate bonding and hydrophobic interactions. 44,45 Fig. 2 shows the phase transfer of 8 nm Fe 3 O 4 nanoparticles from an organic to an aqueous phase after coating.…”

“…In addition, various nanostructures, such as spherical aggregates, coreshell unimolecular micelles, and cylinders, were synthesized using dodecyl chain-grafted PHEAs with different DS values (DSc 12 ). 45 Here, we fixed the DS of the alkyl chain at a value appropriate for preparation of PAIONs with core-shell morphologies, and with ultra-small diameters less than 30 nm, for MRI application.…”

“…Both coordinate covalent bonding and hydrophobic van der Waals interaction have afforded good nanoparticle stability in aqueous solution. 44,45 PHEA-coated iron oxide nanoparticles have the following advantages: (1) high stability in water, remaining less than 30 nm in diameter even after several lyophilizations; (2) biocompatibility and biodegradability; (3) high T 2 relaxivity coefficients; (4) simple polymer coating of magnetic nanoparticles that are 4-11 nm in diameter; (5) ease of functionality, such as conjugation of target moieties to PHEA graft copolymers and (6) high Fe wt% content.…”