Tunable phase transition behaviors of pH-sensitive polyaspartamides having various cationic pendant groups

Park, Han Woong; Jin, Hye-Seung; Yang, Sung Yun; Kim, Jong-Duk

doi:10.1007/s00396-009-2046-8

Cited by 13 publications

(8 citation statements)

References 22 publications

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“…73 The pH-induced phase transitions of P(DMAEMA-co-CMA) copolymers, in aqueous solutions, were investigated by turbidity, light scattering and z-potential measurements. Fig.…”

Section: Aqueous Solution Propertiesmentioning

confidence: 99%

Synthesis, self-assembly and stimuli responsive properties of cholesterol conjugated polymers

et al. 2012

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Reversible addition-fragmentation chain transfer (RAFT) polymerization was used to generate welldefined pH-responsive biofunctional polymers as potential 'smart' gene delivery systems. A series of five poly(dimethylamino ethyl methacrylate-co-cholesteryl methacrylate) P(DMAEMA-co-CMA) statistical copolymers, with similar molecular weights and varying cholesterol content, were prepared. The syntheses, compositions and molecular weight distributions for P(DMAEMA-co-CMA) were monitored by nuclear magnetic resonance (NMR), solid-state NMR and gel permeation chromatography (GPC) evidencing well-defined polymeric structures with narrow polydispersities. Aqueous solution properties of the copolymers were investigated using turbidimetry and light scattering to determine hydrodynamic diameters and zeta potentials associated with the phase transition behaviour of P(DMAEMA-co-CMA) copolymers. UV-Visible spectroscopy was used to investigate the pH-responsive behaviour of copolymers. Hydrodynamic radii were measured in the range 10-30 nm (pH, temperature dependent) by dynamic light scattering (DLS). Charge studies indicated that P(DMAEMA-co-CMA) polymers have an overall cationic charge, mediated by pH. Potentiometric studies revealed that the buffering capacity and pK a values of polymers were dependent on cholesterol content as well as on cationic charge. The buffering capacity increased with increasing charge ratio, overall demonstrating transitions in the pH endosomal region for all five copolymeric structures. Cell viability assay showed that the copolymers displayed increasing cytotoxicity with decreasing number of cholesterol moieties. These preliminary results show the potential of these welldefined P(DMAEMA-co-CMA) polymers as in vitro siRNA delivery agents.

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“…73 The pH-induced phase transitions of P(DMAEMA-co-CMA) copolymers, in aqueous solutions, were investigated by turbidity, light scattering and z-potential measurements. Fig.…”

Section: Aqueous Solution Propertiesmentioning

confidence: 99%

Synthesis, self-assembly and stimuli responsive properties of cholesterol conjugated polymers

et al. 2012

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“…Phase transition of polymers may be induced by external stimuli, such as temperature, 1,6 pH, 20 light, 21 electric field, 22 and solvent composition. 23 Alexandridis and Hatton 24 studied Pluronic triblock copolymers composed of PEO and poly(propylene oxide) (PPO/PPO) that were used as polymeric surfactants.…”

Section: Amphiphilic Polymersmentioning

confidence: 99%

Cyclodextrin-assisted assembly of stimuli-responsive polymers in aqueous media

Yuen

Tam

2010

Soft Matter

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This review explores the advances in stimuli-responsive polymeric inclusion complexes, comprising of cyclodextrins, in aqueous media. Cyclodextrin complexation allows these polymeric systems to possess tailored physical properties that permit them to form novel supramolecular structures. By including and combining stimuli-responsive characteristics, these special systems can transform into various morphologies when exposed to different kinds of external stimuli. A wide variety of these stimuliresponsive polyrotaxanes and functionalized cyclodextrin polymers that possess interesting supramolecular characteristics are discussed, with specific focus on pH-, temperature-, photo-and redox-sensitive systems. These unusual polymer/cyclodextrin systems provide a basis for many useful applications, such as drug delivery, environmentally friendly coatings, personal home care products, separation processes, food processing, and microelectronics.

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“…pH and ionic strength are other stimuli to lead to changes in membrane properties. Response to pH changes is generally due to protonation/deprotonation of ionizable side groups of polyelectrolytes such as carboxyl, pyridine, imidazole, and dibuthylamine groups [239][240] . For non-porous membranes embedded with pH-sensitive carriers, swelling/deswelling of the carriers caused by pH changes can control membrane permeability and selectivity.…”

Section: Ph-and Ionic Strength-responsementioning

confidence: 99%

1.6 Advanced Polymeric and Organic–Inorganic Membranes for Pressure-Driven Processes

Duong

Nunes

2017

Comprehensive Membrane Science and Engineering

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The state of the art of membranes for reverse-osmosis, nanofiltration and gas separation is shortly reviewed, taking in account the most representative examples currently in application. Emphasis is done also on recent developments of advanced polymeric and organic-inorganic materials for pressure driven processes. Many of the more recent membranes are not only polymeric but contain also an inorganic phase. Tailoring innovative materials with organic and inorganic phases coexisting in a nanoscale with multi-functionalization is an appealing approach to control at the same time diffusivity and gas solubility. Other advanced materials, which are now being considered for membrane development are organic or organic-inorganic self-assemblies, metal-organic frameworks and different forms of carbon fillers.

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Tunable phase transition behaviors of pH-sensitive polyaspartamides having various cationic pendant groups

Cited by 13 publications

References 22 publications

Synthesis, self-assembly and stimuli responsive properties of cholesterol conjugated polymers

Synthesis, self-assembly and stimuli responsive properties of cholesterol conjugated polymers

Cyclodextrin-assisted assembly of stimuli-responsive polymers in aqueous media

1.6 Advanced Polymeric and Organic–Inorganic Membranes for Pressure-Driven Processes

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