Aqueous solution behavior of thermosensitive (N-isopropylacrylamide-acrylic acid-ethyl methacrylate) terpolymers

Tiera, Márcio José; Santos, Gérson Rodrigues dos; Tiera, Vera Aparecida de Oliveira; Vieira, Neide Aparecida Blaz; Frolini, Elisabete; Silva, Rodrigo da; Loh, Watson

doi:10.1007/s00396-004-1198-9

Cited by 32 publications

(26 citation statements)

References 43 publications

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“…As with other pH-sensitive copolymers, the deprotonization would be a required step for micellization [16,59,60]. The properties of the core of these micelles can strongly differ from those of the Pluronic Ò micelles since the hydrophilic diamine group connects the hydrophobic PPO chains [61].…”

Section: Effect Of Phmentioning

confidence: 97%

Induced micellization and micellar transitions in aqueous solutions of non-linear block copolymer Tetronic® T904

Kadam

Singh²,

Marangoni³

et al. 2010

Journal of Colloid and Interface Science

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Section: Effect Of Phmentioning

confidence: 97%

Induced micellization and micellar transitions in aqueous solutions of non-linear block copolymer Tetronic® T904

Kadam

Singh²,

Marangoni³

et al. 2010

Journal of Colloid and Interface Science

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“…The LCST aer 60 h was below 25 C, which was consistent with the observation of the phase transition. Indeed, the LCST of PNIPAm is decreased in high PNIPAm concentration, 49 high salt concentration, 50 and molecular crowding environments. 51 Thus, the mechanisms of this system are as follows: CS, PNIPAm, and acetic acid concentrations gradually increase with water evaporation, which involves LCST decreases of PNI-PAm.…”

Section: Resultsmentioning

confidence: 99%

Honeycomb-like porous chitosan films prepared via phase transition of poly(N-isopropylacrylamide) during water evaporation under ambient conditions

et al. 2020

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“…13,14 Many pharmacologically active compounds are used as amphiphilic or hydrophobic molecules in controlled release systems. 15,16 Amphiphilic systems can be obtained through the synthesis of polymers containing both hydrophobic and hydrophilic structures and/or weak acidic monomers. 17 Polymers responsive to temperature and pH changes in aqueous solutions can be obtained by changing hydrophobic or hydrophilic groups in the gel structure.…”

Section: Swelling Testmentioning

confidence: 99%

A Novel Designed Chitosan Based Hydrogel Which is Capable of Consecutively Controlled Release of TGF-Beta 1 and BMP-7

Yılmaz¹,

Gokay²,

Gökçe³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Both Bone Morphogenetic Protein 7 (BMP-7) and Transforming Growth Factor Beta 1 (TGF-β1) have stimulating effects on chondrocyte proliferation. These growth factors act at different time points of the biological repair process. We aimed to design a hydrogel, which would enable consecutive controlled release of the growth factors. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : We designed a chitosan particle impregnated Poly (vinylalcohol) (PVA)-borax hydrogel (CPBH). CPBH allowed controlled release of BMP-7 and TGF-β1 at different time points. Hydrogel structure was analyzed by Scanning Electron Microscope (SEM). The release kinetics of Growth Factors (GFs) were determined with enzyme-linked immunosorbent assay (ELISA) and UV-spectrophotometer. Chondrocyte viability and toxicity were tested through CellTiter 96 ® Non-Radioactive Cell Proliferation (MTS) ELISA. R Re es su ul lt ts s: : The designed hydrogel showed high swelling and mucoadhesion characteristics under acidic conditions. CPBH released BMP-7 first and rapidly and TGF-β1 consecutively and slowly. It also allowed controlled release of protein/peptide based drugs for 21 days without altering their bioactive properties. At the end of 21 days, 82.62% of BMP-7 and 98.34% of TGF-β1 were consecutively released. The difference between the groups was significant (for TGF-β1, p<0.05 and for BMP-7, p<0.001). C Co on nc cl lu us si io on n: : The controlled and slow release of growth factors has been shown to be beneficial on cartilage regeneration. As it is not cytotoxic, we suggest that this hydrogel might be used in medical and pharmaceutical applications areas. K Ke ey y W Wo or rd ds s: : Delayed-action preparations; hydrogels; TGF-β1 protein, human; bone morphogenetic protein 7 Ö ÖZ ZE ET T A Am ma aç ç: : Kemik Morfojenik Proteini-7 (BMP-7) ve Transforme edici Büyüme Faktörü Beta-1 (TGF-β1)'in kıkırdak hücreleri üzerinde prolifere edici etkileri bulunmaktadır. Bu büyüme faktörlerinin etkisi biyolojik tamir sürecinin farklı zamanlarında gerçekleşmektedir. Bu çalışmada, büyüme faktörlerinin ardışık ve kontrollü olarak salınımını gerçekleştirecek bir hidrojel tasarlamayı amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu amaçla kitosan emdirilmiş polivinil alkol (PVA)-boraks hidrojeli (CPBH) tasarlandı. Bu hidrojel BMP-7 ve TGF-β1'in farklı zamanlarda kontrollü salınımını sağladı. Tasarladığımız hidrojelin yüzey yapısı taramalı elektron mikroskobu (SEM) ile değerlendirildi. Büyüme faktörlerinin salım kinetiği enzim aracılı immün deney (ELISA) ve ultraviyole (UV)spektrofotometre ile saptandı. Kondrosit canlılığı ve toksisite testi "CellTiter 96 ® Non-Radioactive Cell Proliferation (MTS)" ELISA yöntemiyle değerlendirildi. B Bu ul lg gu ul la ar r: : Tasarlanan hidrojel, asidik ortam koşullarında büyük oranda şişme ve mukoadezyon özellikleri sergiledi. CPBH, önce hızlı bir biçimde BMP-7'nin, sonra da yavaş olarak TGF-β1'in salınımını ardışık olarak gerçekleştirdi. İçerisindeki p...

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Aqueous solution behavior of thermosensitive (N-isopropylacrylamide-acrylic acid-ethyl methacrylate) terpolymers

Cited by 32 publications

References 43 publications

Induced micellization and micellar transitions in aqueous solutions of non-linear block copolymer Tetronic® T904

Induced micellization and micellar transitions in aqueous solutions of non-linear block copolymer Tetronic® T904

Honeycomb-like porous chitosan films prepared via phase transition of poly(N-isopropylacrylamide) during water evaporation under ambient conditions

A Novel Designed Chitosan Based Hydrogel Which is Capable of Consecutively Controlled Release of TGF-Beta 1 and BMP-7

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