Aqueous synthesis of PEGylated copper sulfide nanoparticles for photoacoustic imaging of tumors

Ding, Ke; Zeng, Jianfeng; Jing, Lihong; Qiao, Ruirui; Liu, Chunyan; Jiao, Mingxia; Li, Zhen; Gao, Mingyuan

doi:10.1039/c5nr02180d

Cited by 75 publications

(45 citation statements)

References 45 publications

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“…9,10 Therefore, optoacoustic imaging has been rapidly developed for visualizing biological structures in biomedical fields, and various exogenous absorbers in the nearinfrared region known as contrast agents have also been investigated for enhancing the imaging effect. [11][12][13] Meanwhile, among cancer treatment methods, photothermal therapy has become a strong candidate in cancer treatment and therapy since it can induce the targeted heat destruction of tumor regions. [14][15][16] Photothermal therapy refers to a photosensitizer that is excited with near-infrared wavelength light, which is more penetrative and less harmful to other cells and tissues.…”

Section: Introductionmentioning

confidence: 99%

Glucose-functionalized Au nanoprisms for optoacoustic imaging and near-infrared photothermal therapy

et al. 2016

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Targeted imaging and tumor therapy using nanomaterials has stimulated research interest recently, but the high cytotoxicity and low cellular uptake of nanomaterials limit their bioapplication. In this paper, glucose (Glc) was chosen to functionalize Au nanoprisms (NPrs) for improving the cytotoxicity and cellular uptake of Au@PEG-Glc NPrs into cancer cells. Glucose is a primary source of energy at the cellular level and at cellular membranes for cell recognition. A coating of glucose facilitates the accumulation of Au@PEG-Glc NPrs in a tumor region much more than Au@PEG NPrs. Due to the high accumulation and excellent photoabsorbing property of Au@PEG-Glc NPrs, enhanced optoacoustic imaging of a tumor in vivo was achieved, and visualization of the tumor further guided cancer treatment. Based on the optical-thermal conversion performance of Au@PEG-Glc NPrs, the tumor in vivo was effectively cured through photothermal therapy. The current work demonstrates the great potential of Au@PEG-Glc NPrs in optoacoustic imaging and photothermal cancer therapy in future.

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Section: Introductionmentioning

confidence: 99%

Glucose-functionalized Au nanoprisms for optoacoustic imaging and near-infrared photothermal therapy

et al. 2016

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“…Copper sulfides have attracted significant attention over the past few decades as potential material candidates for a number of advanced applications, ranging from optoelectronics to biomedical devices . The early studies on copper sulfide materials were motivated by the superconductivity ( T c = 1.6 K) and the certain similarity of CuS to the copper oxide high‐ T c superconductors owing to its quasi‐2D layered crystal structure .…”

Section: Introductionmentioning

confidence: 99%

Atomic Layer Deposition of Conducting CuS Thin Films from Elemental Sulfur

Tripathi

Lahtinen

Karppinen

2018

Adv Materials Inter

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Copper sulfide thin films have been fabricated by various deposition techniques, such as chemical vapor deposition, [15] sputtering, spray pyrolysis, [16,17] chemical bath deposition, [18,19] and electrochemical methods. [20][21][22] However, in most cases the required control over the film stoichiometry and phase composition is poorly achieved due to the coexistence of several stable and metastable copper sulfide phases. [23] Moreover, fabrication of continuous copper sulfide coatings with a well-controlled morphology on highaspect-ratio nanostructures has remained a challenge. It is here in particular where the atomic layer deposition (ALD) technique could provide us with clear advantages over the other thin-film technologies for the deposition of high-quality copper sulfide thin films for various advanced applications including the photovoltaics. [17,24,25] Atomic layer deposition is based on sequential and self-limiting gas-surface reactions and is known to yield exceptionally homogeneous coatings in atomic-scale precision independent of the substrate geometry.The vast majority of the metal sulfide ALD processes is based on metal-organic precursors together with hydrogen sulfide H 2 S as the source of sulfur; [26] the same applies to the reported copper sulfide ALD processes as well (see Table 1). The main merit of H 2 S is that it is highly reactive toward common metal precursors. However, H 2 S is a flammable, corrosive, and highly toxic gas, and its incorporation in the ALD technology presents several serious technical challenges. The special precautions required for the safe use of H 2 S may even be one of the reasons why only 16 metal sulfide ALD processes have been so far reported during the half a century long ALD history. [26] Another drawback of the H 2 S-based ALD processes is the slowness of these processes, see, e.g., the growth rate values given in Table 1 for the copper sulfide processes. Moreover, majority of the reported copper sulfide processes yields Cu(I) sulfide as the main phase; hence, there is a clear interest in a new robust and efficient ALD process for high-quality Cu(II) sulfide thin films. [27] Despite the fact that some of the early ALD processes employed elemental sulfur instead of H 2 S as the sulfur source, [35] to the best of our knowledge no sulfur-based ALD processes have been reported for copper sulfide thin films. Here, we present a simple and efficient low-temperature ALD process for the deposition of high-quality p-type conducting CuS thin films from copper acetyl acetonate and elemental sulfur precursors, as a highly viable solution to the challenges discussed above.A facile, yet precisely controlled and efficient atomic layer deposition (ALD) process is reported for high-quality copper(II) sulfide thin films based on elemental solid sulfur as the source for sulfur; Cu(acac) 2 (acac: acetylacetonate) is used as the copper precursor. In the deposition temperature range as low as 140-160 °C, the process proceeds in an essentially ideal ALD manner and yields single-phase C...

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“…The size of nanoparticles is an equally important parameter for determining the attained optoacoustic signal intensity. A particle size-dependent contrast enhancement effect was shown for copper sulfide nanoparticles with sizes between 3 and 7 nm [315]. While the in vitro contrast enhancement effect was proportional to the particle size, the latter has equally affected pharmacokinetics in vivo .…”

Section: Applications Enabled By Optoacoustic Visualization Of Multmentioning

confidence: 99%

Advanced optoacoustic methods for multiscale imaging of in vivo dynamics

et al. 2017

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Visualization of dynamic functional and molecular events in an unperturbed in vivo environment is essential for understanding the complex biology of living organisms and of disease state and progression. To this end, optoacoustic (photoacoustic) sensing and imaging have demonstrated the exclusive capacity to maintain excellent optical contrast and high resolution in deep-tissue observations, far beyond the penetration limits of modern microscopy. Yet, the time domain is paramount for the observation and study of complex biological interactions that may be invisible in single snapshots of living systems. This review focuses on the recent advances in optoacoustic imaging assisted by smart molecular labeling and dynamic contrast enhancement approaches that enable new types of multiscale dynamic observations not attainable with other bio-imaging modalities. A wealth of investigated new research topics and clinical applications is further discussed, including imaging of large-scale brain activity patterns, volumetric visualization of moving organs and contrast agent kinetics, molecular imaging using targeted and genetically expressed labels, as well as three-dimensional handheld diagnostics of human subjects.

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Aqueous synthesis of PEGylated copper sulfide nanoparticles for photoacoustic imaging of tumors

Cited by 75 publications

References 45 publications

Glucose-functionalized Au nanoprisms for optoacoustic imaging and near-infrared photothermal therapy

Glucose-functionalized Au nanoprisms for optoacoustic imaging and near-infrared photothermal therapy

Atomic Layer Deposition of Conducting CuS Thin Films from Elemental Sulfur

Advanced optoacoustic methods for multiscale imaging of in vivo dynamics

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