Arabidopsis DAL1 and DAL2, two RING finger proteins homologous to Drosophila DIAP1, are involved in regulation of programmed cell death

Basnayake, B. M. Vindhya S.; Li, Dayong; Zhang, Huijuan; Li, Guojun; Virk, Nasar; Song, Fengming

doi:10.1007/s00299-010-0941-6

Cited by 26 publications

(22 citation statements)

References 72 publications

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“…Another study reported that SP1 (DAL1) and SPL1 (DAL2) are involved in the regulation of reactive oxygen species (ROS) accumulation and programmed cell death (52). A more recent study showed that SP1 promotes stress tolerance by depleting TOC components, leading to diminished ROS produced in photosynthesis (53).…”

Section: Discussionmentioning

confidence: 99%

E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis

Pan

Satkovich

2016

Proc. Natl. Acad. Sci. U.S.A.

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Peroxisomes are ubiquitous eukaryotic organelles that play pivotal roles in a suite of metabolic processes and often act coordinately with other organelles, such as chloroplasts and mitochondria. Peroxisomes import proteins to the peroxisome matrix by peroxins (PEX proteins), but how the function of the PEX proteins is regulated is poorly understood. In this study, we identified the Arabidopsis RING (really interesting new gene) type E3 ubiquitin ligase SP1 [suppressor of plastid protein import locus 1 (ppi1) 1] as a peroxisome membrane protein with a regulatory role in peroxisome protein import. SP1 interacts physically with the two components of the peroxisome protein docking complex PEX13-PEX14 and the (RING)-finger peroxin PEX2. Loss of SP1 function suppresses defects of the pex14-2 and pex13-1 mutants, and SP1 is involved in the degradation of PEX13 and possibly PEX14 and all three RING peroxins. An in vivo ubiquitination assay showed that SP1 has the ability to promote PEX13 ubiquitination. Our study has revealed that, in addition to its previously reported function in chloroplast biogenesis, SP1 plays a role in peroxisome biogenesis. The same E3 ubiquitin ligase promotes the destabilization of components of two distinct protein-import machineries, indicating that degradation of organelle biogenesis factors by the ubiquitin-proteasome system may constitute an important regulatory mechanism in coordinating the biogenesis of metabolically linked organelles in eukaryotes.peroxisome biogenesis | E3 ubiquitin ligase | protein import | peroxin | SP1

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Section: Discussionmentioning

confidence: 99%

E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis

Pan

Satkovich

2016

Proc. Natl. Acad. Sci. U.S.A.

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“…This suggests that the turnover of TOC components was affected. Our previous studies have found that the sterile anther in 7365A displays delayed tapetal programmed cell death (PCD) Zhou et al, 2011;Song et al, 2016), and another study reported that SP1 is involved in the regulation of PCD (Basnayake et al, 2011). So, SP1 mediating UPS may be affected in 7365A.…”

Section: Researchmentioning

confidence: 99%

Two young genes reshape a novel interaction network in Brassica napus

et al. 2019

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Summary New genes often drive the evolution of gene interaction networks. In Brassica napus, the widely used genic male sterile breeding system 7365ABC is controlled by two young genes, Bnams4b and BnaMs3. However, the interaction mechanism of these two young genes remains unclear. Here, we confirmed that Bnams4b interacts with the nuclear localised E3 ligase BRUTUS (BTS). Ectopic expression of AtBRUTUS (AtBTS) and comparison between Bnams4b‐transgenic Arabidopsis and bts mutants suggested that Bnams4b may drive translocation of BTS to cause various toxic defects. BnaMs3 gained an exclusive interaction with the plastid outer‐membrane translocon Toc33 compared with Bnams3 and AtTic40, and specifically compensated for the toxic effects of Bnams4b. Heat shock treatment also rescued the sterile phenotype, and high temperature suppressed the interaction between Bnams4b and BTS in yeast. Furthermore, the ubiquitin system and TOC (translocon at the outer envelope membrane of chloroplasts) component accumulation were affected in Bnams4b‐transgenic Arabidopsis plants. Taken together, these results indicate that new chimeric Bnams4b carries BTS from nucleus to chloroplast, which may disrupt the normal ubiquitin–proteasome system to cause toxic effects, and these defects can be compensated by BnaMs3−Toc33 interaction or environmental heat shock. It reveals a scenario in which two population‐specific coevolved young genes reshape a novel interaction network in plants.

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“…For example, In A. thaliana, BRH1 is involved in brassinosteroid-responsive19, RIE1 in seed development20, ATL2/ATL9 in defense response2122, XERICO in drought tolerance23, KEG in growth and development24, PEX2/PEX10/PEX12 in peroxisome formation2526, NLA in adaptability to nitrogen limitation27, SHA1 in shoot apical meristem maintenance28, SDIR1 in stress-responsive abscisic acid signaling29, DRIP1 / DRIP2 is in drought response30 , RHA2a/RHA2b in ABA-mediated stress signaling3132, CNI1 in the carbon/nitrogen response for growth phase transition33, SIS3 in sugar response34, XBAT32 in lateral root production by regulating the ethylene biosynthesis35, AtAIRP1 in ABA-dependent response to drought stress36, DAL1/DAL2 in regulation of programmed cell death37, DAF in anther dehiscence38, AtAIRP3 in high-salt and drought stress responses39, RSL1 in seed longevity40, AtRING1A in flowering41, COP1 in photomorphogenesis42, NERF in drought resistance43, STRF1 in salt-stress response44; in B. rapa, BrRZFP1 is involved in cold, salt and dehydration stress45; in B. napus, Bnclg1A-1D is involved in cleistogamy trait formation46.…”

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confidence: 99%

Genome-wide identification, evolution and expression analysis of RING finger protein genes in Brassica rapa

Álam

Yang

Wang

et al. 2017

Sci Rep

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More and more RING finger genes were found to be implicated in various important biological processes. In the present study, a total of 731 RING domains in 715 predicted proteins were identified in Brassica rapa genome (AA, 2n = 20), which were further divided into eight types: RING-H2 (371), RING-HCa (215), RING-HCb (47), RING-v (44), RING-C2 (38), RING-D (10), RING-S/T (5) and RING-G (1). The 715 RING finger proteins were further classified into 51 groups according to the presence of additional domains. 700 RING finger protein genes were mapped to the 10 chromosomes of B. rapa with a range of 47 to 111 genes for each chromosome. 667 RING finger protein genes were expressed in at least one of the six tissues examined, indicating their involvement in various physiological and developmental processes in B. rapa. Hierarchical clustering analysis of RNA-seq data divided them into seven major groups, one of which includes 231 members preferentially expressed in leaf, and constitutes then a panel of gene candidates for studying the genetic and molecular mechanisms of leafy head traits in Brassica crops. Our results lay the foundation for further studies on the classification, evolution and putative functions of RING finger protein genes in Brassica species.

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Arabidopsis DAL1 and DAL2, two RING finger proteins homologous to Drosophila DIAP1, are involved in regulation of programmed cell death

Cited by 26 publications

References 72 publications

E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis

E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis

Two young genes reshape a novel interaction network in Brassica napus

Genome-wide identification, evolution and expression analysis of RING finger protein genes in Brassica rapa

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