2020
DOI: 10.1016/j.ijantimicag.2020.105998
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Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein

Abstract: Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with r… Show more

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Cited by 231 publications
(219 citation statements)
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“…We assessed medications relevant in COVID-19, including (1) COVID-19-specific medications, defined as pharmacological agents under investigation or reported to have effects against COVID-19, including remdesivir [ 8 , 37 ], systemic corticosteroids [ 9 ], tocilizumab [ 16 , 17 ], hydroxychloroquine [ 10 , 11 ], azithromycin [ 11 , 12 ], sarilumab [ 38 ], siltuximab [ 39 ], darunavir/cobicistat [ 13 ], interferon-beta [ 14 , 15 ], nitric oxide [ 40 , 41 ], favipiravir [ 42 ], canakinumab [ 43 ], ravulizumab [ 44 ], ibrutinib [ 45 ], anakinra [ 43 , 46 ], rilonacept [ 47 ], and umifenovir [ 48 ]; and (2) medications that may be used for supportive care in patients with COVID-19, including statins [ 22 ], anti-infective agents (antibiotics, anti-fungal agents, and anti-viral agents for other specific viruses, [ 23 , 24 ], anticoagulants [ 25 , 26 ], inhalers/nebulizers [ 49 ], ACEIs [ 19 21 ], angiotensin receptor blockers [ 19 21 ], proton pump inhibitors [ 27 , 28 ], and H2RAs [ 27 , 29 ]. We assessed inpatient medication use via electronic medication administration data, which are generated when nurses scan patients’ identifying barcodes immediately before medication administration.…”
Section: Methodsmentioning
confidence: 99%
“…We assessed medications relevant in COVID-19, including (1) COVID-19-specific medications, defined as pharmacological agents under investigation or reported to have effects against COVID-19, including remdesivir [ 8 , 37 ], systemic corticosteroids [ 9 ], tocilizumab [ 16 , 17 ], hydroxychloroquine [ 10 , 11 ], azithromycin [ 11 , 12 ], sarilumab [ 38 ], siltuximab [ 39 ], darunavir/cobicistat [ 13 ], interferon-beta [ 14 , 15 ], nitric oxide [ 40 , 41 ], favipiravir [ 42 ], canakinumab [ 43 ], ravulizumab [ 44 ], ibrutinib [ 45 ], anakinra [ 43 , 46 ], rilonacept [ 47 ], and umifenovir [ 48 ]; and (2) medications that may be used for supportive care in patients with COVID-19, including statins [ 22 ], anti-infective agents (antibiotics, anti-fungal agents, and anti-viral agents for other specific viruses, [ 23 , 24 ], anticoagulants [ 25 , 26 ], inhalers/nebulizers [ 49 ], ACEIs [ 19 21 ], angiotensin receptor blockers [ 19 21 ], proton pump inhibitors [ 27 , 28 ], and H2RAs [ 27 , 29 ]. We assessed inpatient medication use via electronic medication administration data, which are generated when nurses scan patients’ identifying barcodes immediately before medication administration.…”
Section: Methodsmentioning
confidence: 99%
“…Arbidol (umifenovir) is a broad-spectrum antiviral and immunomodulatory compound used to treat influenza and many other viruses (314). Analyses of molecular dynamics and structure-guided drug-binding have suggested an efficiency of arbidol at blocking or hampering the trimerization of the SARS-CoV-2 spike glycoprotein, in addition to inhibiting virus-cell interactions, which supports the potential use of arbidol to treat COVID-19 (315).…”
Section: Antiviralsmentioning
confidence: 97%
“…Currently, COVID19 patients are prescribed broad-spectrum antiviral drugs such as Remdesivir (that blocks RdRp), Arbidol (that impedes spike proteins), Ritonavir, Hydroxychloroquine, and a combination of several other drugs ( ) as the first line of defense. 15 , 16 Even though specific antiviral drugs targeting different host and viral proteins are being clinically evaluated, 17 a potential vaccine is the ultimate and permanent solution for the COVID19 pandemic. Toward this end, many strategies for the development of COVID19 vaccines are being implemented, 18 and the global medical fraternity is advancing toward it.…”
mentioning
confidence: 99%