Archaeosomes based on synthetic tetraether-like lipids as novel versatile gene delivery systems

Réthoré, Gildas; Montier, Tristan; Gall, Tony Le; Delépine, Pascal; Cammas‐Marion, Sandrine; Lemiègre, Loı̈c; Lehn, Pierre; Benvegnu, Thierry

doi:10.1039/b618568a

Cited by 68 publications

(51 citation statements)

References 13 publications

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“…The synthetic tetraether lipid GR was used as external standard. Compound GR has an m/z of 1,208, a structure typical of neutral archaeal membrane lipids and presumably does not occur in the environment 63,64 .…”

Section: Methodsmentioning

confidence: 99%

The emergence of modern sea ice cover in the Arctic Ocean

et al. 2014

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Section: Methodsmentioning

confidence: 99%

The emergence of modern sea ice cover in the Arctic Ocean

et al. 2014

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“…The chemical modified archaeal lipid derivative provides more stability to the hydrolysis with other enzymes (Réthoré et al, 2007). The addition of cyclic structure in the lipids appears to be thermo-adaptive response, by which enhanced membrane packing and reduced membrane fluidity (Réthoré et al, 2007).…”

Section: Advantages Of Archaeal Lipidsmentioning

confidence: 99%

“…The potential of combining conventional bilayer-forming lipids with monolayer-forming lipids modulate the membrane properties of CL-DNA complexes. The potential of novel archaeoplexes for in vivo gene transfection into the airway epithelium by nasal instillation or aerosolization with a view to lung-directed gene therapy for cystic fibrosis (Réthoré et al, 2007).…”

Section: As Novel Gene Delivery Systemsmentioning

confidence: 99%

Archaeosomes: an excellent carrier for drug and cell delivery

et al. 2015

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Archaeosomes as liposomes made with one or more ether lipids that are unique to the domain of Archaeobacteria, found in Archaea constitute a novel family of liposome. Achaean-type lipids consist of archaeol (diether) and/or caldarchaeol (tetraether) core structures. Archaeosomes can be produced using standard procedures (hydrated film submitted to sonication, extrusion and detergent dialysis) at any temperature in the physiological range or lower, therefore making it possible to encapsulate thermally stable compounds. Various physiological as well as environmental factors affect its stability. Archaeosomes are widely used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery and delivery of natural antioxidant compounds. In this review article, our major aim was to explore the applications of this new carrier system in pharmaceutical field.

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“…They carriers are biocompatible and biodegradable with high stability cationic lipids with versatile functionality. ARC-DNA complexes were delivered via lung cell line A549 as model therapy for CF [64,65]. …”

Section: Aerosolized Delivery Strategies For Macromolecule Drug Deliverymentioning

confidence: 99%

Carriers for the targeted delivery of aerosolized macromolecules for pulmonary pathologies

Osman

Kaneko

Carini

et al. 2018

Expert Opinion on Drug Delivery

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Introduction: Macromolecules with unique effects and potency are increasingly being considered for application in lung pathologies. Numerous delivery strategies for these macromolecules through the lung have been investigated to improve the targeting and overall efficacy.Areas covered: Targeting approaches from delivery devices, formulation strategies and specific targets are discussed.Expert opinion: Although macromolecules are a heterogeneous group of molecules, a number of strategies have been investigated at the macro, micro, and nanoscopic scale for the delivery of macromolecules to specific sites and cells of lung tissues. Targeted approaches are already in use at the macroscopic scale through inhalation devices and formulations, but targeting strategies at the micro and nanoscopic scale are still in the laboratory stage. The combination of controlling lung deposition and targeting after deposition, through a combination of targeting strategies could be the future direction for the treatment of lung pathologies through the pulmonary route.

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Archaeosomes based on synthetic tetraether-like lipids as novel versatile gene delivery systems

Cited by 68 publications

References 13 publications

The emergence of modern sea ice cover in the Arctic Ocean

The emergence of modern sea ice cover in the Arctic Ocean

Archaeosomes: an excellent carrier for drug and cell delivery

Carriers for the targeted delivery of aerosolized macromolecules for pulmonary pathologies

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