Abstract:Although extensive research is being
done to combat SARS-CoV-2,
we are yet far away from a robust conclusion or strategy. With an
increased amount of vaccine research, nanotechnology has found its
way into vaccine technology. Researchers have explored the use of
various nanostructures for delivering the vaccines for enhanced efficacy.
Apart from acting as delivery platforms, multiple studies have shown
the application of inorganic nanoparticles in suppressing the growth
as well as transmission of the virus. Th… Show more
“…Metal and its oxides, carbon-based nanomaterials, transition metal dichalcogenide, quantum dots, polymer-based nanocomposites, and other nanomaterials are among the latest smart nanomaterials, which are being widely used for biosensing applications for combating against SARS-CoV-2 infection (various nanoparticles for combating against SARS-CoV-2, see Figure 2 ) [16] . The unique properties of these nanomaterials and their composites, such as small size, signal generation, quenching, and signal amplification, are significant for biosensors fabrication.…”
Section: Smart Nanomaterials For Biosensing Technologies and Their Consequencesmentioning
confidence: 99%
“…Eng. 7 (2021) 31–54 [16] ). Figure 3 Schematic representation of the basic mechanism of nano-material-based biosensors for POCT of SARS-CoV-2 infection (reproduced with permission from A. Pandey et al, ACS Biomater.…”
Section: Smart Nanomaterials For Biosensing Technologies and Their Consequencesmentioning
“…Metal and its oxides, carbon-based nanomaterials, transition metal dichalcogenide, quantum dots, polymer-based nanocomposites, and other nanomaterials are among the latest smart nanomaterials, which are being widely used for biosensing applications for combating against SARS-CoV-2 infection (various nanoparticles for combating against SARS-CoV-2, see Figure 2 ) [16] . The unique properties of these nanomaterials and their composites, such as small size, signal generation, quenching, and signal amplification, are significant for biosensors fabrication.…”
Section: Smart Nanomaterials For Biosensing Technologies and Their Consequencesmentioning
confidence: 99%
“…Eng. 7 (2021) 31–54 [16] ). Figure 3 Schematic representation of the basic mechanism of nano-material-based biosensors for POCT of SARS-CoV-2 infection (reproduced with permission from A. Pandey et al, ACS Biomater.…”
Section: Smart Nanomaterials For Biosensing Technologies and Their Consequencesmentioning
A sensitive method for diagnosing coronavirus disease 2019 (COVID-19) is highly required to fight the current and future global health threats due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2). However, most of the current methods exhibited high false-negative rates, resulting in patient misdiagnosis and impeding early treatment. Nanoparticles show promising performance and great potential to serve as a platform for diagnosing viral infection in a short time and with high sensitivity. This review highlighted the potential of nanoparticles as platforms for the diagnosis of COVID-19. Nanoparticles such as gold nanoparticles, magnetic nanoparticles, and graphene (G) were applied to detect SARS-CoV 2. They have been used for molecular-based diagnosis methods and serological methods. Nanoparticles improved specificity and shorten the time required for the diagnosis. They may be implemented into small devices that facilitate the self-diagnosis at home or in places such as airports and shops. Nanoparticles-based methods can be used for the analysis of virus-contaminated samples from a patient, surface, and air. The advantages and challenges were discussed to introduce useful information for designing a sensitive, fast, and low-cost diagnostic method. This review aims to present a helpful survey for the lesson learned from handling this outbreak to prepare ourself for future pandemic.
“…are reported to exhibit potential antiviral properties against Ebola, Influenza, HIV, and also SARS viruses by the mechanism of interfering with the primary viral pathogenetic processes, inhibition of the viral entry into the host cells as well as inhibiting the RNA replication process or virus budding processes [19–20] . The use of transition metal complexes for antiviral applications is an emerging trend and it becomes very important to explore the potential role of transition metal complexes as the alternative therapeutic option against SARS‐CoV‐2 and other mutant strains of SARS‐CoV‐2 [21–23] …”
Section: Introductionmentioning
confidence: 99%
“…[ 19 , 20 ] The use of transition metal complexes for antiviral applications is an emerging trend and it becomes very important to explore the potential role of transition metal complexes as the alternative therapeutic option against SARS‐CoV‐2 and other mutant strains of SARS‐CoV‐2. [ 21 , 22 , 23 ]…”
The earth has witnessed the greatest global health crisis due to the outbreak of the SARS‐CoV‐2 virus in late 2019, resulting in the pandemic COVID‐19 with 3.38 million mortality and 163 million infections across 222 nations. Therefore, there is an urgent need for an effective therapeutic option against the SARS‐CoV‐2 virus. Transition metal complexes with unique chemical, kinetic and thermodynamic properties have recently emerged as the viable alternative for medicinal applications. Herein, the potential application of selected antiviral transition metal‐based compounds against the SARS‐CoV‐2 virus was explored in silico. Initially, the transition metal‐based antiviral compounds (1‐5) were identified based on the structural similarity of the viral proteins (proteases, reverse transcriptase, envelop glycoproteins, etc.) of HIV, HCV, or Influenza virus with the proteins (S‐protein, RNA‐dependent RNA polymerase, proteases, etc) of SARS‐CoV‐2 virus. Hence the complexes (1‐5) were subjected to ADME analysis for toxicology and pharmacokinetics report and further for the molecular docking calculations, selectively with the viral proteins of the SARS‐CoV‐2 virus. The molecular docking studies revealed that the iron‐porphyrin complex (1) and antimalarial drug, ferroquine (2) could be the potential inhibitors of Main protease (Mpro) and spike proteins respectively of SARS‐CoV‐2 virus. The complex 1 exhibited high binding energy of −11.74 kcal/mol with the Mpro of SARS‐CoV‐2. Similarly ferroquine exhibitred binding energy of −7.43 kcal/mol against spike protein of SARS‐CoV‐2. The complex 5 also exhibited good binding constants values of −7.67, −8.68 and −7.82 kcal/mol with the spike protein, Mpro and RNA dependent RNA polymerase (RdRp) proteins respectively. Overall, transition metal complexes could provide an alternative and viable therapeutic solution for COVID‐19.
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