Are Active Microbiological Surveillance and Subsequent Isolation Needed to Prevent the Spread of Methicillin-Resistant Staphylococcus aureus?

Nijssen, S.; Bonten, Marc J. M.; Weinstein, Robert A.

doi:10.1086/427281

Cited by 97 publications

(70 citation statements)

References 17 publications

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“…Although hospital staff members were aware of the assigned strategy, which could have resulted in unmeasured behavior that affected trial outcomes, 29 it is unclear what unmeasured behavior could effect a 44% improvement. This trial provides no information on the attributable benefit of mupirocin, either alone or in combination with chlorhexidine.…”

Section: Discussionmentioning

confidence: 99%

Targeted Versus Universal Decolonization to Prevent ICU Infection

Huang

Septimus

Kleinman

et al. 2014

Survey of Anesthesiology

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Section: Discussionmentioning

confidence: 99%

Targeted Versus Universal Decolonization to Prevent ICU Infection

Huang

Septimus

Kleinman

et al. 2014

Survey of Anesthesiology

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“…It is frequently isolated from abscesses, whitlows, paronychia and infected eczema (ROTTER, 1999) and has been implicated in ascending urinary tract colonization and infection (MUDER et al, 2006). Methicillin-resistant S. aureus (MRSA) is the most important healthcare associated infectious agent as a result of its presence in up to 20% of inpatients and 16% of healthcare workers and its ability to survive on surfaces for over 12 days (NIJSSEN et al, 2005;HUANG et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

In vitro inhibitory effects of the ethanol extract of Tetrapleura tetraptera (Schum and thonn.) taub. against multidrug resistant staphylococcus aureus

Olajuyigbe¹,

Afolayan²

2018

Kragujevac J Science

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ABSTRACT. In this study, the antibacterial effect of ethanol extract of Tetrapleura tetraptera was investigated in vitro against methicillin-resistant Staphylococcus aureus by agar diffusion and macrobroth dilution methods. At the lowest concentration of 20 mg/ml of the ethanol extract, 100 µl produced inhibition zones that ranged between 06 and 15 ± 1.0 mm while the inhibition zones ranged between 16 ± 1.0 mm and 22 ± 1.0 mm when the isolates were tested with 100 µl of the highest concentration (100 mg/ml) of ethanol extract. The minimum inhibitory concentrations (MICs) of the ethanol extract were between 0.019 mg/ml and 5.0 mg/ml while its minimum bactericidal concentrations (MBCs) ranged between 0.078 and 10.0 mg/ml. Ten strains had their MICs less than 1.0 mg/ml while the remaining S. aureus strains had their MICs at concentrations ranging between 1.25 mg/ml and 5.0 mg/ml. The degree of antibacterial activity exhibited by the extract of T. tetraptera demonstrated that its herbal medicine could be as effective as modern medicine in treating diseases associated with the test pathogenic organism and justifying its traditional use in the treatment of bacterial infections.

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“…Therefore, the rapid identification of MRSA carriers is essential for implementation of targeted infection control measures to prevent dissemination. Active surveillance cultures for MRSA are now part of clinical practice recommendations both in Europe and the United States (16,18,22). The current Belgian recommendations for MRSA screening are to culture swabs from nares and other skin and mucosal sites with enrichment broths and selective media.…”

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confidence: 99%

Controlled Evaluation of the IDI-MRSA Assay for Detection of Colonization by Methicillin-Resistant Staphylococcus aureus in Diverse Mucocutaneous Specimens

et al. 2007

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Rapid and reliable detection of methicillin-resistant Staphylococcus aureus (MRSA) carriers is crucial for the effective control of MRSA transmission in healthcare facilities. The aim of this study was to verify the performance of the IDI-MRSA real-time PCR assay for direct MRSA detection in diverse mucocutaneous swabs from hospitalized patients. Swabs from nares (n ‫؍‬ 522) and skin or other superficial sites (n ‫؍‬ 478) were prospectively collected for MRSA screening from 466 patients admitted to an 858-bed teaching hospital. Swabs were inoculated onto selective chromogenic MRSA-ID agar, buffer extraction solution for IDI-MRSA assay, and enrichment broth. MRSA was detected by culture in 100 specimens from 47 patients. Compared to enrichment culture, the sensitivity and specificity of the PCR assay were 81.0 and 97.0%, respectively, and its positive and negative predictive values were 75.0 and 97.9%, respectively. The IDI-MRSA assay was more sensitive on swabs from nares (90.6%) than from other body sites (76.5%, P < 0.01). The PCR assay detected MRSA in 42 of 47 patients with culture positive study samples. Of 26 patients with culture-negative but PCR-positive study samples, 11 were probable true MRSA carriers based on patient history and/or positive culture on a new sample. The median turnaround time for PCR results was 19 h versus 3 days for agar culture results and 6 days for enrichment culture results. These data confirm the value of IDI-MRSA assay for rapid screening of MRSA mucocutaneous carriage among hospitalized patients. Cost-effectiveness studies are warranted to evaluate the impact of this assay on infection control procedures in healthcare settings.Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major nosocomial pathogens responsible for a wide spectrum of infections, including skin and soft tissue infections, pneumonia, bacteraemia, surgical site infections, and catheterrelated infections. In Europe, up to 50% of nosocomial bloodstream S. aureus infections are due to MRSA. In Belgium, the proportion of MRSA isolates from blood cultures in hospitalized patients has risen from 22% in 1999 to 31.4% in 2005 (8). MRSA isolation from an inpatient is associated with increased risk of nosocomial infection and an excess of morbidity and hospitalization costs (4). The main mode of MRSA transmission is from MRSA-colonized or -infected patients to another one through indirect contact via the transiently colonized hands of healthcare workers. Therefore, the rapid identification of MRSA carriers is essential for implementation of targeted infection control measures to prevent dissemination. Active surveillance cultures for MRSA are now part of clinical practice recommendations both in Europe and the United States (16,18,22). The current Belgian recommendations for MRSA screening are to culture swabs from nares and other skin and mucosal sites with enrichment broths and selective media. However, the results of the conventional screening methods are generally not available before 48 h, in spite ...

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Are Active Microbiological Surveillance and Subsequent Isolation Needed to Prevent the Spread of Methicillin-Resistant Staphylococcus aureus?

Cited by 97 publications

References 17 publications

Targeted Versus Universal Decolonization to Prevent ICU Infection

Targeted Versus Universal Decolonization to Prevent ICU Infection

In vitro inhibitory effects of the ethanol extract of Tetrapleura tetraptera (Schum and thonn.) taub. against multidrug resistant staphylococcus aureus

Controlled Evaluation of the IDI-MRSA Assay for Detection of Colonization by Methicillin-Resistant Staphylococcus aureus in Diverse Mucocutaneous Specimens

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