The aim of this study was to analyze the relationships between cybervictimization, family functioning, and self-concept in adolescents, while taking the gender perspective into account. A study was conducted with a sample of 8115 adolescents, aged between 11 and 16 years (M = 13.34; SD = 1.04) from the State of Nuevo Leon, Mexico. A MANOVA 3x2 was performed to analyze the data. The results showed that family functioning, family self-concept, and academic self-concept were higher when cybervictimization was low. It was also observed that, in situations of cybervictimization, the girls had lower family self-concept, lower academic self-concept, and lower family functioning than the boys. The results that were obtained and their implications are discussed in the final section.