Are Asian coronary arteries smaller than Caucasian? A study on angiographic coronary artery size estimation during life

Dhawan, J; Bray, Colin

doi:10.1016/0167-5273(95)02315-n

Cited by 89 publications

(52 citation statements)

References 7 publications

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“…Interestingly, association of T-1131C with elevated plasma TG and lower HDL cholesterol was also reported in a study of Japanese schoolchildren (52). Study of Eastern Asian populations consuming a Western diet revealed an increase of coronary disease and prevalence equivalent to that observed in Caucasian populations (53)(54)(55)(56)(57). This suggests that the role of APOAV in TG metabolism in these populations has a significant impact on coronary disease and warrants further investigation.…”

Section: Discussionmentioning

confidence: 78%

Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids

Aouizerat

Kulkarni

Heilbron

et al. 2003

Journal of Lipid Research

109

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Recent discovery and characterization of APOAV suggests a role in metabolism of triglyceride (TG)-rich lipoproteins. Previously, variation at the APOAV locus was shown to modestly influence plasma TGs in normolipidemic samples. The aims of this study were to assess the effects of a polymorphism in APOAV (T-1131C) in terms of its frequency among three dyslipidemic populations and a control population, differences of allele frequency across available ethnic groups, and associations with specific lipoprotein TG and cholesterol compartments. We found a striking elevation in the frequency of the rare allele in a Chinese population ( P ‫؍‬ 0.0002) compared with Hispanic and European populations. The rare allele of the polymorphism was associated with elevated plasma TG ( P ‫؍‬ 0.012), VLDL cholesterol ( P ‫؍‬ 0.0007), and VLDL TG ( P ‫؍‬ 0.012), LDL TG ( P ‫؍‬ 0.003), and HDL TG ( P ‫؍‬ 0.016). Linear regression models predict that possession of the rare allele elevates plasma TG by 21 mg/dl ( P ‫؍‬ 0.009) and VLDL cholesterol by 8 mg/dl ( P ‫؍‬ 0.0001), and reduces HDL cholesterol by 2 mg/dl ( P ‫؍‬ 0.017). The association of the polymorphism with altered lipoprotein profiles was observed in combined hyperlipidemia, hypoalphalipoproteinemia, and hyperalphalipoproteinemia, and in controls. These findings indicate that APOAV is an important determinant of plasma TG and lipoprotein cholesterol, and is potentially a risk factor for cardiovascular disease. -Aouizerat, B.

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Section: Discussionmentioning

confidence: 78%

Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids

Aouizerat

Kulkarni

Heilbron

et al. 2003

Journal of Lipid Research

109

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“…In addition, 44% of the patients in CORONARY were of South Asian or East Asian ethnic groups, populations that are known to have smaller coronary arteries. [30][31][32] Therefore the apparent differences in results between the ROOBY trial and CORONARY may be due to differences in the baseline risk of the patients as well as the differences in the experience levels of the surgeons.…”

Section: Discussionmentioning

confidence: 99%

Effects of Off-Pump and On-Pump Coronary-Artery Bypass Grafting at 1 Year

Lamy¹,

Devereaux²,

Prabhakaran³

et al. 2014

Survey of Anesthesiology

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BACKGROUND: Previously, we reported that there was no significant difference at 30 days in the rate of a primary composite outcome of death, myocardial infarction, stroke, or new renal failure requiring dialysis between patients who underwent coronary-artery bypass grafting (CABG) performed with a beating-heart technique (off-pump) and those who underwent CABG performed with cardiopulmonary bypass (on-pump). We now report results on quality of life and cognitive function and on clinical outcomes at 1 year. METHODS: We enrolled 4752 patients with coronary artery disease who were scheduled to undergo CABG and randomly assigned them to undergo the procedure off-pump or on-pump. Patients were enrolled at 79 centers in 19 countries. We assessed quality of life and cognitive function at discharge, at 30 days, and at 1 year and clinical outcomes at 1 year. RESULTS: At 1 year, there was no significant difference in the rate of the primary composite outcome between off-pump and on-pump CABG (12.1% and 13.3%, respectively; hazard ratio with off-pump CABG, 0.91; 95% confidence interval [CI], 0.77 to 1.07; P=0.24). The rate of the primary outcome was also similar in the two groups in the period between 31 days and 1 year (hazard ratio, 0.79; 95% CI, 0.55 to 1.13; P=0.19). The rate of repeat coronary revascularization at 1 year was 1.4% in the off-pump group and 0.8% in the on-pump group (hazard ratio, 1.66; 95% CI, 0.95 to 2.89; P=0.07). There were no significant differences between the two groups at 1 year in measures of quality of life or neurocognitive function. CONCLUSIONS: At 1 year after CABG, there was no significant difference between off-pump and on-pump CABG with respect to the primary composite outcome, the rate of repeat coronary revascularization, quality of life, or neurocognitive function. (Funded by the Canadian Institutes of Health Research; CORONARY ClinicalTrials.gov number, NCT00463294.).

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“…Population origin and true race-specific genetic effects might explain these results, since functional analyses of variation in the ACE gene have indicated that different loci control ACE levels in particular 'racial' groups (51). For example, it has been reported the inconsistencies in the risk effects of ACE I/D on restenosis between Caucasian and East Asian populations might be due to race-related anatomical differences in coronary arteries, since a smaller total vessel diameter has been described for Asian populations (52). Besides, a recent report also pointed out the role of ACE I/D gene polymorphism for some diseases in Caucasian children is different from that in Asian children (53).…”

Section: Stratified Meta-analysis For Ace I/dmentioning

confidence: 99%

Combining Geographic Region with Meta-Analysis to Map the Potential Association between Three Genetic Polymorphisms and Coronary Artery Disease

Hua¹,

Lin²,

Zhou³

et al. 2013

Journal of Medical Biochemistry

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SummaryBackground: Coronary artery disease (CAD) is a complex trait influenced by genetic and environmental factors. Geographic isolation and natural selection present fundamental forces to diversify genetic backgrounds during human evolution and migration. In this study, we attempted to assess whether human geographic isolation affects the genetic predisposition of CAD. Methods: We first included 21 genetic association studies of the methyl enetetrahydrofolate reductase (MTHFR) gene polymorphism C677T and CAD from 16 geographic regions consisting of 9,008 participants and performed a meta-analysis based on the distributions of these studies. Results: It was found that the positive signals for the association of C677T with CAD were mainly enriched in the regions of northern Afri ca (pooled OR=1.73, 95% CI=1.45-2.06, Z=3.17, P<0.0001) and India (pooled OR=1.61, 95% CI=1.30-2.00, Z=4.38, P<0.0001). To validate the potential geographic effects on the genetic polymorphism of CAD, we then carried out two additional metaanalyses involving 30 and 13 studies on genetic associations of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) and APOA5 gene T1131C polymorphisms for CAD consisting of 22,190 and 12,322 participants, respectively. We found that the associations of T1131C with CAD were concentrated in East Asia (pooled OR=1.35, 95% CI=1.22-1.49, Z=6.00, P<10-5), whereas the associations of I/D polymorphism with CAD were clustering in Europe and America (pooled OR=1.20, 95%

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Are Asian coronary arteries smaller than Caucasian? A study on angiographic coronary artery size estimation during life

Cited by 89 publications

References 7 publications

Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids

Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids

Effects of Off-Pump and On-Pump Coronary-Artery Bypass Grafting at 1 Year

Combining Geographic Region with Meta-Analysis to Map the Potential Association between Three Genetic Polymorphisms and Coronary Artery Disease

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