Are Auditory-Evoked Frequency and Duration Mismatch Negativity Deficits Endophenotypic for Schizophrenia? High-Density Electrical Mapping in Clinically Unaffected First-Degree Relatives and First-Episode and Chronic Schizophrenia

Paying attention to MMN in schizophrenia

“…(Cornblatt et al, 1989;Cornblatt and Keilp, 1994;Fisher et al, 1994;Nuechterlein et al, 1994), not remediated by psychotropic medication (Catts et al, 1995;Nielsen et al, 2012;Schall et al, 1998;Shinozaki et al, 2002;Umbricht et al, 1998;Umbricht et al, 1999;cf. Lavoie et al, 2008;Zhou et al, 2013), and has been observed in clinical high-risk individuals (Bodatsch et al, 2011;Nuechterlein, 1983;Pflueger et al, 2007) and equivocally in asymptomatic first-degree relatives (Cornblatt and Keilp, 1994;Bramon et al, 2004;Jessen et al, 2001;Magno et al, 2008;Michie et al, 2002;Nuechterlein et al, 1994;Rosburg et al, 2004). Although both reduced MMN and attentional impairments are heavily studied in schizophrenia, they are typically studied independently of each other.…”

“…It is present in the prodromal stages of the illness (Bodatsch et al, 2011;Brockhaus-Dumke et al, 2005 Q5 ), likely independent of psychotic state 1 Q6 (Fisher et al, 2014), not remediated by psychotropic medication (Catts et al, 1995;Schall et al, 1998;Shinozaki et al, 2002;Umbricht et al, 1998;Umbricht et al, 1999; Q7 cf. Lavoie et al, 2008;Zhou et al, 2013), and has been observed in clinical high-risk individuals that later transition to the illness (e.g., Bodatsch et al, 2011) and equivocally in asymptomatic first-degree relatives (Bramon et al, 2004;Jessen et al, 2001;Magno et al, 2008;Michie et al, 2002;Rosburg et al, 2004). Despite this, very little is known about the functional relevance of reduced MMN in persons with schizophrenia.…”

Mismatch negativity (MMN) reduction in schizophrenia—Impaired prediction-error generation, estimation or salience?

“…MMN amplitude is considered sufficiently reliable and heritable to be an informative tool in the study of factors contributing to altered brain function in this illness (Hall et al, 2006). The examination of MMN in healthy relatives of persons with schizophrenia has been equivocal (Bramon et al, 2004;Jessen et al, 2001;Magno et al, 2008;Michie et al, 2002;Rosburg et al, 2004) but this is perhaps not surprising. Schizophrenia is an illness with established but complex heritability (Cardno et al, 1999).…”

Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients

“…MMN amplitude reduction in schizophrenia is well-documented (Naatanen & Kahkonen, 2009; Nagai et al, 2013a; Umbricht & Krljes, 2005), including in chronic (Brockhaus-Dumke et al, 2005; Catts et al, 1995; Jahshan et al, 2012; Javitt, Doneshka, Zylberman, Ritter, & Vaughan, 1993; Javitt, Grochowski, Shelley, & Ritter, 1998; Javitt, Shelley, Silipo, & Lieberman, 2000b; Kiang, Braff, Sprock, & Light, 2009; Light & Braff, 2005; Magno et al, 2008; Michie et al, 2000; Oades et al, 2006; Oknina et al, 2005; Rasser et al, 2011; Salisbury, Shenton, Griggs, Bonner-Jackson, & McCarley, 2002; Shelley et al, 1991; Umbricht, Bates, Lieberman, Kane, & Javitt, 2006), recent onset (Atkinson, Michie, & Schall, 2012; Jahshan et al, 2012; Javitt et al, 2000b; Kaur et al, 2011, 2012b, 2013, Perez et al, 2014; Todd et al, 2008; Umbricht et al, 2006), and some (Bodatsch et al, 2011; Brockhaus-Dumke et al, 2005; Catts et al, 1995) but not all (Devrim-Ucok, Keskin-Ergen, & Ucok, 2008; Kirino & Inoue, 1999; Korostenskaja et al, 2005) unmedicated patients. The status of MMN in first episode schizophrenia is more controversial, with some studies reporting reduced frequency-deviant MMN (Oknina et al, 2005) or duration-deviant MMN (Bodatsch et al, 2011; Hermens et al, 2010; Kaur et al, 2011; Nagai et al, 2013b; Oades et al, 2006), at least in patients lacking any college education (Umbricht et al, 2006), but other studies reporting normal duration-deviant MMN (Magno et al, 2008) or frequency-deviant MMN (Bodatsch et al, 2011; Devrim-Ucok et al, 2008; Magno et al, 2008; Nagai et al, 2013b; Salisbury et al, 2002; Valkonen-Korhonen et al, 2003).…”