Are Bile Acids Involved in the Renal Dysfunction of Obstructive Jaundice? An Experimental Study in Bile Duct Ligated Rats

Abstract

Transient functional impairment of renal cation and water transport and nonspecific morphological changes in the proximal convoluted tubule occur 3 to 4 days following bile duct ligation in rats. These functional and morphological changes occurred when plasma total and urinary bile acids were at their peaks. Although it is tempting to equate association with causality, we cannot implicate bile acids as being responsible for the aberrations in renal function and structure following BDL. Accordingly, we have concluded that elevated plasma concentrations of bile acids are renal exacerbates acting in concert with other factors, be they prerenal or renal in origin to precipitate a cascade of events leading to postoperative renal failure in cholestasis.

Alteration of Methotrexate Biliary and Renal Elimination during Extrahepatic and Intrahepatic Cholestasis in Rats

“…Although the exact mechanism of this effect is not known because studies of transporter expression do not reflect the situation, animal and human studies point to the harmful effect of increased bilirubin serum concentration on proximal tubular cells during cholestasis. 45,46) In agreement with this, the absence of increased bilirubin concentration in plasma of LPS-administered animals ( Fig. 2A) was associated with only a moderate decrease in the renal clearance of the compound (Fig.…”

Toxicology effects of Morning Glory Seed in rat: A metabonomic method for profiling of urine metabolic changes

“…The result presented an increased bile acids level in the urine of MGS-treated rats, which may indicate that liver damage has also occurred simultaneously (Li et al, 2007). In obstructive liver disease bile salts are known to accumulate in and damage specific kidney cells (Dawson and Stirling, 1964;Wardle, 1975;Kaler et al, 2004;Heuman, 1989;Morgan et al, 1998). In other words, elevated bile acid level caused by liver damage will increase the nephrotoxicity induced by MGS in current state.…”

The effect of albumin administration on renal dysfunction after experimental surgical obstructive jaundice in male rats

“…Experimentally, the in vitro addition of excess bile acids or bilirubin to a mixture of reactive enzymes inhibited mitochondrial oxidative enzymes. Thus, high concentrations of these substances in the blood may explain the development of renal failure during cholestatic liver disorders [6]. The blockage of the biliary pathway in cholestasis may cause an overload on the kidney with a consequent disturbance of the kidney function, which may progress to renal failure [7].…”