Are biosensor arrays in one membrane possible? A combination of multifrequency impedance measurements and chemometrics

Abstract

A novel concept of a membrane-based micro-array biosensor is presented. The methodology is based on a single lipid membrane interrogated with electrochemical impedance techniques followed by multivariate data analysis. A single membrane is designed so that relaxation processes with a range of time constants can be probed at different potentials. A range of other approaches cited in the literature is reviewed.

Non‐invasive identification of melanoma with near‐infrared and skin impedance spectroscopy

“…By this, the highest frequencies had a value close to unity and lower frequencies described the deviation from the ideal RC-circuit. (23,24) Replicates of all collected spectra were averaged and two matrices were constructed, i.e. one for NIR spectra (NIR matrix, 50 objects and 2281 variables) and one for the skin impedance spectra (IMP matrix, 50 objects and 51 variables).…”

Analysis of Temperature-Jump Boundary Conditions on Heat Transfer for Heterogeneous Microfluidic Immunosensors

“…In the biomedical field, many biochemical processes such as mixing [ 6 ] and sensing [ 7 , 8 ] can be integrated into a single chip. Biosensors represent powerful tools used in several applications such as drug discovery, medical diagnostics, and security and defense [ 9 ]. The interest of microfluidic biosensors is that they offer several advantages such as lower cost, higher sensitivity, faster response time, and lower sample consumption [ 10 ].…”

Microfluidics Integrated Biosensors: A Leading Technology towards Lab-on-a-Chip and Sensing Applications

“…Biosensors are considered to be powerful analytical tools and are potentially useful for a wide range of applications ranging from drug discovery, to medical diagnostics, to food safety, to agricultural and environmental monitoring, and to security and defense [ 1 ]. A biosensor can be defined as an analytical device [ 1 , 2 ] that combines a biological sensitive recognition element [ 3 ] (such as antibodies, nucleic acids, enzymes, or aptamers) immobilized on a physicochemical transducer, and connected to a detector to identify the presence of one or more specific analytes [ 4 ], their concentrations, and kinetics in a sample. The specificity and selectivity of the biosensor is determined by the catalytic or affinity properties of the biological recognition element.…”