Are children born from singleton pregnancies conceived by ICSI at increased risk
            for congenital malformations when compared to children conceived naturally? A systematic
            review and meta-analysis

Lacamara, Celeste; Ortega, Carolina; Villa, Sonia; Pommer, Ricardo; Schwarze, Juan Enrique

doi:10.5935/1518-0557.20170047

Cited by 36 publications

(17 citation statements)

References 34 publications

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“…Cassuto et al (2014) showed that intracytoplasmic injection of morphologically selected spermatozoa significantly decreased the incidence of major birth defects compared with ICSI. A meta‐analysis review found that infants conceived from ICSI were at an increased incidence of birth defects compared with naturally conceived newborns (Lacamara, Ortega, Villa, Pommer, & Schwarze, 2017). The assisted reproductive treatments used in our retrospective study were c‐IVF, and a very small number of cases were subjected to early RICSI; the rates of birth defects in newborns were not significantly different between the two groups (Table 6).…”

Section: Discussionmentioning

confidence: 99%

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Chen

Liu

et al. 2020

Andrologia

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The present study assessed the influences of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional in vitro fertilisation cycles. This retrospective study analysed 427 and 2,728 cycles from the normal sperm morphology rate <4% and ≥4% group respectively. The clinical (total fertilisation failure, clinical pregnancy, implantation and abortion) and neonatal (sex, gestational age, preterm birth, birthweight, low birth weight, live births and birth defects of newborns) outcomes were compared. The rate of total fertilisation failure in the normal sperm morphology rate <4% group was significantly higher compared with that in the normal sperm morphology rate ≥4% group (2.8% versus 1.2%, p = .012). Total fertilisation failure was completely resolved by early rescue intracytoplasmic sperm injection. The clinical pregnancy, implantation and abortion rates were not significantly different between the two groups. Additionally, the sex, preterm birth, low birth weight, live births and birth defect rates, gestational age and birthweight of newborns were not significantly different between the two groups. Thus, normal sperm morphology rate <4% significantly increased the total fertilisation failure rate but did not affect the clinical or neonatal outcomes.

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Section: Discussionmentioning

confidence: 99%

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Chen

Liu

et al. 2020

Andrologia

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“…A number of studies have reported that in-vitro fertilization (IVF) or ICSI -conceived offspring, even if they are singleton pregnancies, are associated with low birth weights and preterm deliveries [24,25]. Metaanalysis studies have also concluded that children conceived from IVF and ICSI can present with an increased risk for congenital malformations compared with those naturally conceived, although these risks did not differ between IVF and ICSI [26][27][28]. Concerns with respect to the safety of using immotile spermatozoa for ICSI have arisen mainly as some assisted conception methods have used chemical substances to select viable spermatozoa [29,30].…”

Section: Discussionmentioning

confidence: 99%

Laser-assisted selection of immotile spermatozoa has no effect on obstetric and neonatal outcomes of TESA-ICSI pregnancies

Chen

Wang

Zhou

et al. 2021

Preprint

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Background Azoospermic patients have benefited from both epididymal and testicular spermatozoa intracytoplasmic sperm injection (ICSI) treatment and lasers have been used to identify viable but immotile spermatozoa before the procedure. However, there are limited studies on the safety of laser-assisted selection of immotile spermatozoa. The aim of this study was to investigate the impact of laser-assisted selection of immotile spermatozoa on the obstetric and neonatal outcomes after ICSI. Methods A retrospective comparative study was conducted on patients who underwent ICSI treatment with testicular spermatozoa in our Reproductive Medicine Unit from June 2014 to June 2018. The 132 cycles were divided into two groups according to whether laser-assisted selection of spermatozoa was used. Results Compared with control group, no significant differences were found in the pregnancy, implantation, miscarriage and live birth rates in the laser group in either fresh or frozen transfer cycles. The cumulative live birth rate in the laser group was 69.70%, which was slightly higher than in the control group (60.61%), but this was not statistically different. There were no differences in the average gestational age, premature birth rate, neonatal birth weight and the malformation rate between the laser and control groups (P > 0.05). In addition, the obstetric outcome between the two groups were not different (P > 0.05). Conclusions No negative effect on perinatal and neonatal outcomes was seen by using laser-assisted selection of immotile spermatozoa for TESA-ICSI. This study endorses the use of laser-assisted selection of viable spermatozoa for ICSI cycles.

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“…However, in advanced oligospermia and asthenozoospermia that require ICSI, the reason is the high incidence of spermatozoa with chromosomal abnormalities. The risk of congenital malformation is 7.1% for ICSI and 4.0% for the general population (OR: 1.99, 95% CI: 1.87‐2.11) 91 . It has been reported that when sperm is damaged by oxidative stress, sperm DNA is damaged.…”

Section: Possibility Of Chromosomal Abnormal Pregnancy In Oligospermimentioning

confidence: 99%

Genetic counseling prior to assisted reproductive technology

Katagiri

Tamaki

2020

Reprod Medicine & Biology

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Background Reproductive medicine deals with fertility and is closely related to heredity. In reproductive medicine, it is necessary to provide genetic information for the patients prior to assisted reproductive technology (ART). Japan Society for Reproductive Medicine (JSRM) requires doctors involved in reproductive medicine to have standard knowledge of reproductive genetics and knowledge of reproductive medicine, which is covered in their publication, “required knowledge of reproductive medicine.” Methods With the aim of providing straightforward explanations to patients in the clinical situation at pre‐ART counseling, we provide the following five topics, such as (a) risk of birth defects in children born with ART, (b) chromosomal abnormalities, (c) Y chromosome microdeletions (YCMs), (d) possible chromosomal abnormal pregnancy in oligospermatozoa requiring ICSI (intracytoplasmic sperm injection), and (e) epigenetic alterations. Main findings The frequency of chromosome abnormalities in infertile patients is 0.595%‐0.64%. YCMs are observed in 2%‐10% of severe oligospermic men. High incidence of spermatozoa with chromosomal abnormalities has been reported in advanced oligospermia and asthenozoospermia that require ICSI. Some epigenetic alterations were reported in the children born with ART. Conclusion Certain genetic knowledge is important for professionals involved in reproductive medicine, even if they are not genetic experts.

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Are children born from singleton pregnancies conceived by ICSI at increased risk for congenital malformations when compared to children conceived naturally? A systematic review and meta-analysis

Cited by 36 publications

References 34 publications

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Laser-assisted selection of immotile spermatozoa has no effect on obstetric and neonatal outcomes of TESA-ICSI pregnancies

Genetic counseling prior to assisted reproductive technology

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