Are concentrations of clusterin and beta-2-glycoprotein I dysregulated in HIV associated preeclampsia?

Mlambo, Zinhle P; Varaden, Deneshree; Moodley, Jagidesa; Naicker, Thajasvarie

doi:10.1016/j.ejogrb.2020.03.036

Cited by 3 publications

(2 citation statements)

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“…Serum Amyloid A (SAA) levels associated with HDL fractions (dilution 1:200) were evaluated using SAA bioplex kit (Merck Millipore) using the manufacturer's instructions. A broad panel of Apolipoprotein (ApoA‐I, ApoA‐II, ApoC‐I, ApoC‐III, ApoD, ApoE, ApoH, ApoJ, and CRP) levels associated with HDL fractions (dilution 1:10,000) were evaluated using Pro Human Apolipoprotein Panel bioplex kit (Biorad) using the manufacturer's instructions (Jóźwiak et al, 2022; Mlambo et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

Plasma high‐density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume

Pedrini

Doecke

Hone

et al. 2022

Journal of Neurochemistry

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Cholesterol levels have been repeatedly linked to Alzheimer's Disease (AD), suggesting that high levels could be detrimental, but this effect is likely attributed to Low-Density Lipoprotein (LDL) cholesterol. On the other hand, High-Density Lipoproteins (HDL) cholesterol levels have been associated with reduced brain amyloidosis and improved cognitive function. However, recent findings have suggested that HDL-functionality, which depends upon the HDL-cargo proteins associated with HDL, rather than HDL levels, appears to be the key factor, suggesting a quality over quantity status. In this This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Methodsmentioning

confidence: 99%

Plasma high‐density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume

Pedrini

Doecke

Hone

et al. 2022

Journal of Neurochemistry

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“…Other than the upregulated genes discussed above, Lamin A/C (LMNA) and Clusterin (CLU), which were involved in metabolic laminopathies and apoptosis, were found to be significantly downregulated in our HIV-infected and aged group [ 57 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 81%

Accelerated Neuroimmune Dysfunction in Aged HIV-1-Infected Humanized Mice

Zhang,

Su,

Waight

et al. 2024

Pharmaceuticals

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Disordered immunity, aging, human immunodeficiency virus type one (HIV-1) infection, and responses to antiretroviral therapy are linked. However, how each factor is linked with the other(s) remains incompletely understood. It has been reported that accelerated aging, advanced HIV-1 infection, inflammation, and host genetic factors are associated with host cellular, mitochondrial, and metabolic alterations. However, the underlying mechanism remains elusive. With these questions in mind, we used chronically HIV-1-infected CD34-NSG humanized mice (hu-mice) to model older people living with HIV and uncover associations between HIV-1 infection and aging. Adult humanized mice were infected with HIV-1 at the age of 20 weeks and maintained for another 40 weeks before sacrifice. Animal brains were collected and subjected to transcriptomics, qPCR, and immunofluorescence assays to uncover immune disease-based biomarkers. CD4+ T cell decline was associated with viral level and age. Upregulated C1QA, CD163, and CXCL16 and downregulated LMNA and CLU were identified as age-associated genes tied to HIV-1 infection. Ingenuity pathway analysis affirmed links to innate immune activation, pyroptosis signaling, neuroinflammation, mitochondrial dysfunction, cellular senescence, and neuronal dysfunction. In summary, CD34-NSG humanized mice are identified as a valuable model for studying HIV-1-associated aging. Biomarkers of immune senescence and neuronal signaling are both age- and virus-associated. By exploring the underlying biological mechanisms that are linked to these biomarkers, interventions for next generation HIV-1-infected patients can be realized.

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