Are Environmental Levels of Bisphenol A Associated with Reproductive Function in Fertile Men?

Mendiola, Jaime; Jørgensen, Niels; Andersson, Anna‐Maria; Calafat, Antònia M.; Ye, Xiaoyun; Redmon, J. Bruce; Drobnis, Erma Z.; Wang, Christina; Sparks, Amy E.T.; Thurston, Sally W.; Liu, Fan; Swan, Shanna H.

doi:10.1289/ehp.1002037

Cited by 209 publications

(176 citation statements)

References 43 publications

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“…Nonetheless, neither free testosterone nor LH levels are affected in these conditions (Hanaoka et al, 2002). In male partners of pregnant women, urinary BPA levels have been inversely associated only with the free androgen index (FAI: testosterone/SHBG; sex hormone-binding globulin; Mendiola et al, 2010). In men attending fertility clinics, urinary BPA concentrations are associated with a decline in semen quality parameters (Meeker et al, 2010b;Knez et al, 2014), and appear to influence inhibin B, FSH, and the estradiol/testosterone ratio (Meeker et al, 2010a).…”

Section: Inhibin Bmentioning

confidence: 99%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

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WHAT IS KNOWN ALREADY:The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption. STUDY DESIGN, SIZE, DURATION:Adult human testis explants in culture were exposed to BPA and the analogs bisphenol F (BPF), bisphenol S (BPS), bisphenol E (BPE), bisphenol B (BPB), and bisphenol A diglycidyl ether (BADGE) at 10 -9 to 10 -5 M for 24 h or 48h.PARTICIPANTS/MATERIALS, SETTING, METHODS: Human adult testes were obtained from prostate cancer patients who had no hormone therapy, or from multiorgan donors. After ex vivo exposure to the investigated bisphenols, the measured outcomes were related to histopathology (gross morphology and germ cell viability determined by anti-caspase 3 immunohistochemistry), and the levels of testosterone, insulin-like fator 3 and inhibin B were measured using immunoassays. The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase). MAIN RESULTS AND THE ROLE OF CHANCE: A significant dose-dependent inhibition wasfound between testosterone levels measured in the culture medium and concentrations of BPA The active concentrations of BPA and BPA-A used in the study were higher than those found in human biological fluids. WIDER IMPLICATIONS OF THE FINDINGS:Under our experimental conditions, direct exposure to BPA or BPA-A can result in endocrine disturbance in the adult human testis.

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Section: Inhibin Bmentioning

confidence: 99%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

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“…Similar effects have been observed in infertile men with high DEHP levels in semen, who also show an increase in serum estradiol (E2) and prolactin (PRL) (Li et al, 2011b). In fertile men, no signifi cant associations were found among any semen parameters and urinary BPA concentrations (Mendiola et al, 2010). However, a signifi cant inverse association was detected among urinary BPA concentrations free androgen index (FAI) levels and the FAI/ LH ratio, as well as a signifi cant positive association between BPA and sex hormone-binding globulin (SHBG).…”

Section: Adverse Effects Of Endocrine Disruptors On Human Fertilitymentioning

confidence: 98%

Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers

Lagos-Cabré¹,

Moreno

2012

Biol. Res.

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Bisphenol A [2,2-bis(4-hydroxyphenyl)propane] (BPA), 4-nonylphenol (NP) and di(2-ethylhexyl)phthalate (DEHP), and its metabolite mono-2-ethylhexyl phthalate (MEHP) are chemicals found in plastics, which act as endocrine disruptors (EDs) in animals, including human. EDs act like hormones in the endocrine system, and disrupt the physiologic function of endogenous hormones. Most people are exposed to different endocrine disruptors and concern has been raised about their true effect on reproductive organs. In the testis, they seem to preferentially attack developing testis during puberty rather than adult organs. However, the lack of information about the molecular mechanism, and the apparently controversial effect observed in different models has hampered the understanding of their effects on mammalian spermatogenesis. In this review, we critically discuss the available information regarding the effect of BPA, NP and DEHP/ MEHP upon mammalian spermatogenesis, a major target of EDs. Germ cell sloughing, disruption of the blood-testis-barrier and germ cell apoptosis are the most common effects reported in the available literature. We propose a model at the molecular level to explain the effects at the cellular level, mainly focused on germ cell apoptosis.

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“…Only a few studies investigating the association between BPA exposure and reproductive/developmental disorders in human subjects have been published since 2007 (Itoh et al, 2007;Padmanabhan et al, 2008;Wolff et al, 2008;Braun et al, 2009;Cobellis et al, 2009;Yang et al, 2009;Li et al, 2010a, b;Meeker et al, 2010;Mendiola et al, 2010;MokLin et al, 2010). Itoh et al (2007) reported no association between urinary BPA concentrations and endometriosis in a cross-sectional study of 140 infertile Japanese women.…”

Section: Other Human Studiesmentioning

confidence: 99%

“…The studies by Li et al (2010a, b), Meeker et al (2010) and Mendiola et al (2010) have addressed male reproductive toxicity in adult individuals.…”

Section: Other Human Studiesmentioning

confidence: 99%

“…The study by Mendiola et al (2010) investigated the relationships between environmental BPA exposure (measured in urine) and reproductive parameters, including semen quality and serum reproductive hormone levels, in prospectively recruited fertile men (n=375). These men were partners of pregnant women who participated in the multicenter Study for Future Families in four U.S. cities between 1999 and 2005.…”

Section: Other Human Studiesmentioning

confidence: 99%

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Untitled

2010

EFSA Journal

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Bisphenol A (BPA) is used in the manufacture of plastics, to produce reusable drinking bottles, infant feeding bottles and other food storage containers. EFSA was asked to evaluate a dietary developmental neurotoxicity study in rats (Stump, 2009) and recent scientific literature (2007)(2008)(2009)(2010) in terms of relevance for the risk assessment of BPA. The impact of these studies on the current Tolerable Daily Intake (TDI) of 0.05 mg BPA/kg body weight (b.w.)/day as set by EFSA in 2006 was assessed. Advice on the Danish risk assessment underlying the Danish ban of BPA in food contact materials for infants aged 0-3 years is included. Overall, based on this comprehensive evaluation of recent toxicity data, the Panel on food contact materials, enzymes, flavourings and processing aids (CEF) concluded that no new study could be identified, which would call for a revision of the current TDI. This TDI is based on the No-Observed-Adverse-Effect-Level (NOAEL) of 5 mg/kg b.w./day from a multi-generation reproductive toxicity study in rats, and the application of an uncertainty factor of 100. This factor is regarded as conservative based on all information on BPA toxicokinetics. The Panel noted that some studies conducted on developing animals have suggested other BPA-related effects of possible toxicological relevance, in particular biochemical changes in brain, immune-modulatory effects and enhanced susceptibility to breast tumours. These studies had several shortcomings. At present the relevance of these findings for human health cannot be assessed. Should any new relevant data become available in the future, the Panel will reconsider this opinion. A minority opinion is expressed by a Panel member and presented in an Annex to this opinion. © European Food Safety Authority, 2010 KEY WORDSBisphenol A, BPA, CAS No. 00080-05-7, developmental toxicity, neurobehaviour, low dose effects. In order to provide a global view on the risk assessment of Bisphenol A, the CEF Panel decided to address the three mandates as given above in a single opinion and postponed the adoption of this comprehensive document to 23 rd September 2010.The three different questions raised by the Commission are dealt with in three different parts (PARTS I to III) of the opinion. PART IV presents an overview of the conclusions from PARTS I to III, together with an overall conclusion. PART IThe GLP compliant study by Stump (2009) was performed according to OECD guideline 426 to address any uncertainty regarding potential neurodevelopmental effects of BPA. BPA was administered daily in the diet at concentrations of 0, 0.15, 1.5, 75, 750, and 2250 mg/kg feed to female Sprague-Dawley rats from gestational day (GD) 0 to postnatal day (PND) 21. The relative estimated intakes (in mg/kg b.w./day) were 0, 0.01, 0.12, 5.85, 56.4 and 164 during gestation and 0, 0.03, 0.25, 13.1, 129 and 410 during lactation. The CEF Panel considers this treatment schedule as relevant to human exposure in utero and via either breastfeeding or infant bottle feeding (in this...

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Are Environmental Levels of Bisphenol A Associated with Reproductive Function in Fertile Men?

Cited by 209 publications

References 43 publications

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers

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