Are Estrogens of Import to Primate/Human Ovarian Folliculogenesis?*

Palter, Steven F.; Tavares, Adriano Bueno; Hourvitz, Ariel; Veldhuis, Johannes D.; Adashi, Eli Y.

doi:10.1210/edrv.22.3.0433

Cited by 93 publications

(32 citation statements)

References 305 publications

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“…Equine chorionic gonadotropin acts as FSH in the hamsters (Greenwald and Roy, 1994) and its prolong action results in follicular development in adult hamsters (Chiras and Greenwald, 1978) and primordial follicle formation in postnatal hamsters (Roy and Albee, 2000). The increase in FSHR mRNA in E-treated postnatal hamsters is consistent with the stimulatory role of E on FSH receptor expression in the ovary (Palter, Tavares, Hourvitz et al, 2001, Richards, Ireland, Rao et al, 1976). …”

Section: Discussionsupporting

confidence: 77%

Expression of FSH receptor in the hamster ovary during perinatal development

Chakraborty

Roy

2015

Molecular and Cellular Endocrinology

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FSH plays an important role in ovarian follicular development, and it functions via the G-protein coupled FSH receptor. The objectives of the present study were to determine if full-length FSHR mRNA and corresponding protein were expressed in fetal through postnatal hamster ovaries to explain the FSH-induced primordial follicle formation, and if FSH or estrogen (E) would affect the expression. A full-length and two alternately spliced FSHR transcripts were expressed from E14 through P20. The level of the full-length FSHR mRNA increased markedly through P7 before stabilizing at a lower level with the formation and activation of primordial follicles. A predicted 87kDa FSHR protein band was detected in fetal through P4 ovaries, but additional bands appeared as ovary developed. FSHR immunosignal was present in undifferentiated somatic cells and oocytes in early postnatal ovaries, but was granulosa cells specific after follicles formed. Both eCG and E significantly up-regulated full-length FSHR mRNA levels. Therefore, FSHR is expressed in the hamster ovary from the fetal life to account for FSH-induced primordial follicle formation and cAMP production. Further, FSH or E regulates the receptor expression.

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Section: Discussionsupporting

confidence: 77%

Expression of FSH receptor in the hamster ovary during perinatal development

Chakraborty

Roy

2015

Molecular and Cellular Endocrinology

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“…A high dose of E has been shown to induce preantral follicles in immature intact or hypophysectomized rats (Richards et al, 1976b). E has been shown to upregulate FSH receptors in ovarian granulosa cells and to affect ovarian folliculogenesis in many species (Louvet and Vaitukaitis, 1976; Palter et al, 2001). In hypophysectomized immature rats, E fails to induce FSH-receptor within 24 h (Ireland and Richards, 1978), but it can induce FSH-receptor after 4 days of treatment (Richards et al, 1976b).…”

Section: Discussionmentioning

confidence: 99%

Effect of azaline B on follicular development and functions in the hamster

Chakraborty¹,

Roy²

2015

Molecular and Cellular Endocrinology

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The usefulness of azaline B, a GnRH antagonist, in suppressing gonadotropin secretion in the golden hamster was examined by examining follicular development, steroidogenesis and expression of steroidogenic enzymes. Serum levels of P and E declined significantly, while FSH or LH was undetectable in azaline B-treated hamsters. FSH significantly increased serum E levels, whereas LH upregulated serum P levels. The formation of antral follicles ceased in azaline-treated hamsters, but was reversed by FSH with or without LH supplement. FSH also activated the primordial follicle pool resulting in increased formation of primary and preantral follicles. Further, an increasing trend in the formation of preantral follicles in response to E or E + P, and the formation of antral follicles in response to E + P treatment was evident. The level of Cyp11a1 mRNA increased markedly in LH− or LH + FSH-treated hamsters, whereas FSH with or without LH upregulated Cyp17a1, Cyp19a1 and Fshr mRNA expression. E without or with P also upregulated ovarian Cyp19a1 mRNA expression. The expression of enzyme protein corroborated the mRNA data. In summary, azaline B is an efficient GnRH antagonist in the hamster, and will be useful in studying the selective effect of gonadotropins on ovarian functions without disrupting the physiological functions of other hormones in ovarian cells.

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“…They were transferred to veterinary clinic (Dr MUSAVI CLINICE, TABRIZ, IRAN, Dr. Eshrat Khah et al) for sex hormone measurements. The kit (LH ELISA KIT, FSH ELISA KIT, E2 AccuBind ELISA, and Progesterone AccuBind ELISAPishtaz Teb-Iran) is used for counting the amount of hormones, LH, FSH, estrogen, and progesterone, which influence folliculogenesis cycle to ovulation [28][29][30][31][32][33].…”

Section: Blood Serum Measurementmentioning

confidence: 99%

How do red and infrared low-level lasers affect folliculogenesis cycle in rat’s ovary tissue in comparison with clomiphene under in vivo condition

2017

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Folliculogenesis is a cycle that produces the majority of oocyte. Any disruption to this cycle leads to ovulation diseases, like polycystic ovarian syndrome (PCOS). Treatments include drugs and surgery; lasers have also been used complementarily. Meanwhile, still there is no definite treatment for PCOS. This study investigated the photo-bio stimulation effect of near-infrared and red low-level laser on producing follicles and compared the result with result of using common drug, clomiphene. Therefore, the aim of this study was to propose the use of lasers autonomously treatment. So, there was one question: how do lasers affect folliculogenesis cycle in rat's ovary tissue? In this study, 28 rats were assigned to four groups as follows: control (CT), clomiphene drug (D), red laser (RL), and near-infrared laser (NIRL). Afterwards, 14 rats of RL and NIRL groups received laser on the first 2 days of estrous cycle, each 6 days, for 48 days. During treatment period, each rat received energy density of 5 J/cm 2 . Seven rats in D group received clomiphene. After the experiment, lasers' effects at two wavelengths of 630 and 810 nm groups have been investigated and compared with clomiphene and CT groups. Producing different follicles to complement folliculogenesis cycle increased in NIRL and RL groups, but this increase was significant only in the NIRL group. This indicates that NIRL increases ovarian activity to produce oocyte that certainly can be used in future studies for finding a cure to ovarian negligence to produce more oocyte and treat diseases caused by it like PCOS.

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Are Estrogens of Import to Primate/Human Ovarian Folliculogenesis?*

Cited by 93 publications

References 305 publications

Expression of FSH receptor in the hamster ovary during perinatal development

Expression of FSH receptor in the hamster ovary during perinatal development

Effect of azaline B on follicular development and functions in the hamster

How do red and infrared low-level lasers affect folliculogenesis cycle in rat’s ovary tissue in comparison with clomiphene under in vivo condition

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