Are fingernail lead levels a reliable biomarker of lead internal dose?

Olympio, Kelly Polido Kaneshiro; Ferreira, A. B.; Rodrigues, Mhc; Luz,; Albuquerque, L.C. Rameh de; Barbosa, JrF; Cardoso, Mra; Pv, Oliveira; Buzalaf, M. A. R.

doi:10.1016/j.jtemb.2020.126576

Cited by 12 publications

(3 citation statements)

References 23 publications

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“…The use of human tissues (scalp hair and fingernails) and fluids (blood serum or whole, saliva and urine) for determining the levels of trace elements in the human body have been widely published [1][2][3][4]. The measurement of trace element levels in the human body has been used in different situations, namely, to identify and eliminate potential environmental chemical exposure sources [5,6] to; (i) discover a relationship(s) between chemical exposure and human or animal diseases [7,8]; (ii) detect time trends in relation to chemical variations, such as, an evaluation of the effectiveness of bans or restrictions on specific chemical toxins or pollutants [9]; (iii) map the geographical distribution of contaminated regions [10]; and (iv) identify relationships between chemical body burden and dietary system or an occupational exposure [11].…”

Section: Introductionmentioning

confidence: 99%

Use of human teardrop fluid for the determination of trace elements in healthy individuals and diabetic patients

Joda

Ward

2021

Journal of Trace Elements in Medicine and Biology

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Section: Introductionmentioning

confidence: 99%

Use of human teardrop fluid for the determination of trace elements in healthy individuals and diabetic patients

Joda

Ward

2021

Journal of Trace Elements in Medicine and Biology

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“…4 depicts significant differences between groups in fingernails, with higher levels in the highly exposed group (103.3 vs. 82.8 ng/g, p = 0.025), but contrary to our hypothesis, Pb concentration in scalp hair was slightly higher in the moderately exposed group (p = 0.088). Although it is well known that blood and nails can be effective biomarkers of Pb exposure (Barbosa et al, 2005;Olympio et al, 2020), the contradictory results shown here for the three biomarkers studied need further research to elucidate (i) the suitability of these biomarkers to account for the exposure to airborne Pb, and (ii) the contribution of local emission sources other than ferroalloy smelting.…”

Section: Discussionmentioning

confidence: 76%

Short- and long-term exposure to trace metal(loid)s from the production of ferromanganese alloys by personal sampling and biomarkers

Markiv

Ruiz-Azcona

Expósito

et al. 2022

Environ Geochem Health

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The environmental exposure to trace metal(loid)s (As, Cd, Cu, Fe, Mn, Pb, and Zn) was assessed near a ferromanganese alloy plant using filters from personal particulate matter (PM) samplers (bioaccessible and non-bioaccessible fine and coarse fractions) and whole blood as short-term exposure markers, and scalp hair and fingernails as long-term biomarkers, collected from volunteers (n = 130) living in Santander Bay (northern Spain). Bioaccessible and non-bioaccessible metal(loid) concentrations in coarse and fine PM from personal samplers were determined by ICP-MS after extraction/digestion. Metal(loid) concentration in biomarkers was measured after alkaline dilution (whole blood) and acid digestion (fingernails and scalp hair) by ICP-MS as well. Results were discussed in terms of exposure, considering the distance to the main Mn source, and sex. In terms of exposure, significant differences were found for Mn in all the studied fractions of PM, As in whole blood, Mn and Cu in scalp hair and Mn and Pb in fingernails, with all concentrations being higher for those living closer to the Mn source, with the exception of Cu in scalp hair. Furthermore, the analysis of the correlation between Mn levels in the studied biomarkers and the wind-weighted distance to the main source of Mn allows us to conclude that scalp hair and mainly fingernails are appropriate biomarkers of long-term airborne Mn exposure. This was also confirmed by the significant positive correlations between scalp hair Mn and bioaccessible Mn in coarse and fine fractions, and between fingernails Mn and all PM fractions. This implies that people living closer to a ferromanganese alloy plant are exposed to higher levels of airborne metal(loid)s, mainly Mn, leading to higher levels of this metal in scalp hair and fingernails, which according to the literature, might affect some neurological outcomes. According to sex, significant differences were observed for Fe, Cu and Pb in whole blood, with higher concentrations of Fe and Pb in males, and higher levels of Cu in females; and for Mn, Cu, Zn, Cd and Pb in scalp hair, with higher concentrations in males for all metal(loid)s except Cu.

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“…In the meantime, hair, nail and toenail has been used as suitable biomarkers for chronic fluoride exposure due to the water consumption [13]. The trace elements in hair or nail are also investigated as biomarkers in long-term alcohol using, potentially harmful environmental elements to human, lead exposure sources, and clinical research, [14][15][16][17]. A study has found that the zinc content in hair and fingernail and the Zn/Cu ratio in the hair of hypertension and coronary heart patient are lower than those in heathy group [18].…”

Section: Introductionmentioning

confidence: 99%

Identification and determination of the relationship between elemental compounds of hair and fingernail by PIXE technique in Hamadan urban community, Iran

Hatam

2022

J. Phys.: Conf. Ser.

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The measurement of trace elements in nails and hairs has advantages relative to other body tissues and they have been increasingly used in forensic and clinical toxicology as a complementary test. Complementary hair and nail analysis can indicate the amount of elements in the body for long periods of time. In this study, hair and nail samples were collected from the city of Hamedan and the quantitative elemental concentration of samples was measured by PIXE technique. In hair samples of females, P had a significant difference with Cr and Ni, and a moderate difference with Co. The average amounts of Si, K, Cl, Al and Ca of hair samples in athletes were higher than normal people, in turn higher than addicted group. Ca content had a moderate difference between athlete and addicted groups. There was a weak difference between P-Ni and P-Co only for age ranges of 30-40 year. In female nail samples, P had a significant difference with Ca, Cr and Al. The existence of the meaningful difference in the Ca ratio in hair to nail samples can be used as a biomarker in forensic medicine.

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Are fingernail lead levels a reliable biomarker of lead internal dose?

Cited by 12 publications

References 23 publications

Use of human teardrop fluid for the determination of trace elements in healthy individuals and diabetic patients

Use of human teardrop fluid for the determination of trace elements in healthy individuals and diabetic patients

Short- and long-term exposure to trace metal(loid)s from the production of ferromanganese alloys by personal sampling and biomarkers

Identification and determination of the relationship between elemental compounds of hair and fingernail by PIXE technique in Hamadan urban community, Iran

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