Are genes units of inheritance?

Fogle, Thomas A.

doi:10.1007/bf00165258

Cited by 30 publications

(57 citation statements)

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“…La influencia del concepto de gen sobre el pensamiento biológico y su papel en el debate en la definición de vida y muerte, no solo han sido temas de discusión; el término y concepto también han sido sometidos a una exhaustiva revisión histórica y epistemológica motivada por los desarrollos de la biología molecular de las últimas décadas que ponen en relieve la ambigüedades inherentes a sus diversas definiciones, muchas de ellas incompatibles con los descubrimientos de la biología molecular actual (Falk, 1986;Fogle, 1990;Portin, 1993;Griffiths y neumann-Held, 1999;Keller, 2000;stotz, Griffiths y Knight, 2004;moss, 2006;El-Hani, 2007;Knight, 2007).…”

Section: De La Epistemología De Bachelard a La De Canguilhemunclassified

De la Polisemia de los Conceptos.El concepto Gen como caso Particular

Salcedo

2013

Bio

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Entre los conceptos que la historia tradicional de la biología presenta como un concepto reelaborado a través del tiempo, es el concepto gen. 102 Bio-grafía Bio-grafía ResumenLa discusión en torno a los conceptos involucra a filósofos, psicólogos, filósofos, científicos y, en los últimos años, didactas de las ciencias. Este debate es tan relevante por el creciente disenso entre la comunidad científica respecto a la posibilidad de la verdad y de la objetividad en las ciencias y la relación con los conceptos. En el siguiente artículo se discutirá la noción de concepto y, especialmente, la del concepto de gen, sobre el que se pretende mostrar un breve estudio de su desarrollo históri-co (en la biología) que permite identificar diversos significados que responden al contexto explicativo de los distintos episodios y sucesos históricos que tuvieron lugar en el siglo XX.Palabras clave: conceptos, polisemia, epistemología, historia de conceptos (HdC). AbstractThe discussion of the concepts it involves philosophers, psychologists, philosophers and scientists and, in recent years science educators. This debate is as relevant by the growing dissent within the scientific community regarding the possibility of truth and objectivity in science and related concepts. In the next article will discuss the notion of concept and especially the gene concept, on which is intended to show a brief study of its historical development (in biology) that identifies various meanings that respond to the context explaining the different episodes and historical events that took place in the twentieth century.

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Section: De La Epistemología De Bachelard a La De Canguilhemunclassified

De la Polisemia de los Conceptos.El concepto Gen como caso Particular

Salcedo

2013

Bio

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“…In these terms, the molecular understanding of the gene was superimposed onto the Mendelian idea of 'unit' (Fogle, 1990). With the introduction of an informational vocabulary in molecular biology and genetics (see Kay, 2000), genes became not only functional and structural, but also informational units.…”

Section: The Classical Molecular Gene Conceptmentioning

confidence: 99%

“…Fogle (1990) examined four possible structural models for a protein-coding gene (see Figure 1). Model A includes the transcribed region and all neighboring sequences with detectable influences on gene expression.…”

Section: The Classical Molecular Gene Conceptmentioning

confidence: 99%

“…Nevertheless, at the turn of the 21 st century, the future of this concept does not seem so promising, at least for some. In the last three decades, the discovery of a series of phenomena posed important challenges to the gene concept, including split genes, alternative splicing, overlapping and nested genes, mRNA edition, and so on (for reviews, see, for ex., Falk, 1986;Pardini and Guimarães, 1992;Portin, 1993;Griffiths and Neumann-Held, 1999;Keller, 2000;Fogle, 1990Fogle, , 2000.…”

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confidence: 99%

“…With the growth of knowledge in Mendelian genetics, and through a series of developments beyond the scope of this review (such as the building of Morgan's chromosome theory of heredity and advancements in the understanding of the physicochemical basis of the genetic material, as well as of the relationship between genes and proteins -see, for ex., Carlson, 1966;Kitcher, 1982;Mayr, 1982;Falk, 1986;Fogle, 1990;Portin, 1993;Keller, 2000), the instrumentalist attitude was superseded by a material understanding of the gene. A notorious member of Morgan's group, Herman J. Muller, was one of the first supporters of the idea that genes were material units, "ultra-microscopic particles" in the chromosomes, arguing against the description of the gene as "a purely idealistic concept, divorced from real things" (quoted by Falk, 1986).…”

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Between the cross and the sword: the crisis of the gene concept

El-Hani

2007

Genet. Mol. Biol.

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Challenges to the gene concept have shown the difficulty of preserving the classical molecular concept, according to which a gene is a stretch of DNA encoding a functional product (polypeptide or RNA). The main difficulties are related to the overlaying of the Mendelian idea of the gene as a 'unit': the interpretation of genes as structural and/or functional units in the genome is challenged by evidence showing the complexity and diversity of genomic organization. This paper discusses the difficulties faced by the classical molecular concept and addresses alternatives to it. Among the alternatives, it considers distinctions between different gene concepts, such as that between the 'molecular' and the 'evolutionary' gene, or between 'gene-P' (the gene as determinant of phenotypic differences) and 'gene-D' (the gene as developmental resource). It also addresses the process molecular gene concept, according to which genes are understood as the whole molecular process underlying the capacity to express a particular product, rather than as entities in 'bare' DNA; a treatment of genes as sets of domains (exons, introns, promoters, enhancers, etc.) in DNA; and a systemic understanding of genes as combinations of nucleic acid sequences corresponding to a product specified or demarcated by the cellular system. In all these cases, possible contributions to the advancement of our understanding of the architecture and dynamics of the genetic material are emphasized.

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Rethinking genes

Marks¹,

Lyles²

1994

Evolutionary Anthropology

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The gene is the central construct of twentieth‐century biology and evolution. It is a construct because, like “culture” in anthropology, “gene” is widely used and is central to the discipline's discourse, but eludes rigorous definition. Although the gene is acknowledged as a material entity, its membership criteria are unclear and its boundaries are fuzzy—indeed, more than one can occupy the same space at the same time. The purpose of this essay is to bring to light recent refinements in our conception of the gene and their implications for its use in biological anthropology.

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Are genes units of inheritance?

Cited by 30 publications

References 35 publications

De la Polisemia de los Conceptos.El concepto Gen como caso Particular

De la Polisemia de los Conceptos.El concepto Gen como caso Particular

Between the cross and the sword: the crisis of the gene concept

Rethinking genes

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