Are HOMA-IR and HOMA-B good predictors for diabetes and pre-diabetes subtypes?

Abstract

Background To investigate the association between the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Homeostasis Model Assessment of Beta-cell function (HOMA-B) with the incidence of diabetes and pre-diabetes subtypes. Methods A total of 3101 normoglycemic people aged 20–70 years were included in the 6-year follow-up study. Multinomial logistic regression was used to calculate the incidence possibility of isolated Impaired Fasting Glucose (iIFG), isolated Impaired Glucose Tolerance (iIGT), Combined impaired fasting glucose & impaired glucose tolerance (CGI), and Diabetes Mellitus (DM) per standard deviation (SD) increment in HOMA-IR and HOMA-B in the crude and multivariable model. Results In the multivariate model, an increase in one SD change in HOMA-IR was associated with a 43, 42, 75, and 92% increased risk of iIFG, iIGT, CGI, and DM, respectively. There was a positive correlation between the increase in HOMA-B and the incidence of iIGT; however, after adjusting the results for metabolic syndrome components, it was inversely correlated with the incidence of iIFG [Odds Ratio = 0.86(0.75–0.99)]. Conclusions HOMA-IR is positively correlated with diabetes and pre-diabetes subtypes’ incidence, and HOMA-B is inversely correlated with the incidence of iIFG but positively correlated with iIGT incidence. However, none of these alone is a good criterion for predicting diabetes and pre-diabetes.

Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal Histopathological Changes in Diabetic Parkinson’s Rats

“…The biochemical changes post-induction, including elevated fasting blood glucose levels, reduced insulin levels, and decreased striatal dopamine levels contributing to the development of α-synuclein aggregation, collectively confirm the successful establishment of DP rats [ 4 , 20 , 21 , 54 , 55 ]. The alterations in HOMA-IR and HOMA-β indexes confirmed the development of insulin resistance and impaired β-cell function, providing a comprehensive characterization of the model’s metabolic and neurodegenerative features [ 34 , 35 , 56 ].…”

Nutrient patterns in relation to insulin resistance and endothelial dysfunction in Iranian women

“…Moreover, higher adherence to NP3 consisting of SFA, cholesterol, vitamin E, sodium, vitamin B12, zinc, and protein, named as “animal fat and meat + vitamin E nutrient pattern”, was associated with higher values of HOMA-β. Although HOMA-β is considered as an index of beta-cell function, its increased levels have shown to be associated with impaired glucose tolerance, type 2 diabetes, and insulin resistance 38 , 39 . Adhering to the third nutrient pattern in the current investigation has led to higher values of HOMA-β, but resulted in a reduction in QUICKY levels, a definite indicator of insulin resistance 40 , 41 , although this association was not statistically significant (P = 0.19).…”

TAAR1 agonist ulotaront delays gastric emptying of solids in patients with schizophrenia and concurrent metabolic syndrome with prediabetes

“…homeostatic model assessment of insulin resistance [(insulin μIU/ml  glucose mg/dl)/405] ≥2.22. 37,38 Exclusion criteria included a DSM-5 diagnosis other than schizophrenia; a history of diabetes mellitus type I or II; a history of or current use of an oral or injectable glucose-lowering medication; and a history of or current use of a GLP-1R agonist treatment.…”

“…An increased risk for type 2 diabetes (i.e. prediabetes) is evidenced by at least one of the following criteria: glycated haemoglobin (HbA1c; ≤5.7% to ≥6.4%), or fasting homeostatic model assessment of insulin resistance [(insulin μIU/ml × glucose mg/dl)/405] ≥2.22 37,38 …”