Are Human P[14] Rotavirus Strains the Result of Interspecies Transmissions from Sheep or Other Ungulates That Belong to the Mammalian Order Artiodactyla ?

Novel G10P[14] Rotavirus Strain, Northern Territory, Australia

“…With the exception of the VP7 gene, the constellation is consistent with G6P[14] and G8P[14] strains identified globally: G6/G8-P[14]-I2-(R2/R5)-C2-M2-(A3/A11)-N2-T6-(E2/E12)-H3 ( 6 ). Human P[14] strains are related to rotavirus strains isolated from even-toed ungulates belonging to the mammalian order Artiodactyla ( 6 ).…”

“…With the exception of the VP7 gene, the constellation is consistent with G6P[14] and G8P[14] strains identified globally: G6/G8-P[14]-I2-(R2/R5)-C2-M2-(A3/A11)-N2-T6-(E2/E12)-H3 ( 6 ). Human P[14] strains are related to rotavirus strains isolated from even-toed ungulates belonging to the mammalian order Artiodactyla ( 6 ). Consistent with this observation, each individual genome segment of V585 was most closely related to artiodactyl-derived strains or human zoonotic rotavirus strains characterized to be derived from artiodactyl hosts.…”

Rotavirus genotypes in children in the Basque Country (northern Spain) over a 13-year period (July 1996–June 2009)

“…G6 and G8 strains are frequently found in bovine cattle [9] and are rarely detected in human infections in Europe [14,15,18,21,25,26]. Human [P14] rotavirus strains have been reported exceptionally across the globe and probably represent occasional interspecies transmission from ruminants [28]. Likewise, we detected G-type 12 strains, which have recently spread throughout the world and are increasingly identified in Europe [14,25,29].…”

Suspected zoonotic transmission of rotavirus group A in Danish adults

“…the G6P[14] genotype. As already mentioned these human strains have been shown to have a close overall genomic relatedness to ovine and antelope rotavirus strains [6]. The GenBank sequences with the highest nucleotide identity to our strain were the bovine strain Kv0426 (EU873012) and the human strain 111/05-27 (EF554141) with 98% homology to the VP6 sequence.…”

“…PR/1300/04 has a VP7 gene of bovine origin in combination with a human VP4 gene [5] and strain A64 consists mainly of genes of bovine origin together with VP7 and VP3 genes of human origin. Rotaviruses of G8P[14] specificity have been reported in a few children in Europe [5][6][7] and Australia [8]. Other human strains of the G8 genotype, in combination with variety of P-types, have been reported from throughout the world [9].…”