Are intratumoral microbiota involved in the progression of intraductal papillary mucinous neoplasms of the pancreas?

Hozaka, Yuto; Oi, Hideyuki; Satake, Souichi; Uchino, Yoshinori; Goto, Yu‐ichi; Idichi, Tetsuya; Tanoue, Kazuo; Yamasaki, Yoichi; Kawasaki, Yota; Mataki, Yuko; Kurahara, Hiroshi; Nakajo, Akihiro; Higashi, Michiyo; Tanimoto, Akihide; Sugiura, T.; Ohtsuka, Takao

doi:10.1016/j.surg.2022.10.003

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…3 microbiome of pancreatic IPMN by 16S rDNA analysis and detected Firmicutes, Proteobacteria, and Actinobacteria as predominant phyla. 9 This was slightly different from our finding. The difference might be because there was a higher proportion of patients with IPMN-IC in our cohort than in the former study 9 ; we also found that the genus Acinetobacter had a higher relative abundance in the IPMN-IC group than in the IPMN group.…”

Section: Discussioncontrasting

confidence: 99%

“…9 This was slightly different from our finding. The difference might be because there was a higher proportion of patients with IPMN-IC in our cohort than in the former study 9 ; we also found that the genus Acinetobacter had a higher relative abundance in the IPMN-IC group than in the IPMN group. Our data did not reveal significant differences in microbiome diversity between the IPMN group and the IPMN-IC group, but individually different microbes were discovered.…”

Section: Discussioncontrasting

confidence: 99%

“…Hazaka et al . analyzed the tumoral microbiome of pancreatic IPMN by 16S rDNA analysis and detected Firmicutes , Proteobacteria , and Actinobacteria as predominant phyla 9 . This was slightly different from our finding.…”

Section: Discussioncontrasting

confidence: 99%

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The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: A single‐center retrospective cohort study

Zou,

Mo,

Jia

et al. 2023

J of Gastro and Hepatol

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Background and AimPancreatic intraductal papillary mucinous neoplasm (IPMN) is one of the most common precancerous lesions of pancreatic carcinoma. Studies have found that the tumoral microbiome has an important influence on pancreatic carcinoma. However, the tumoral microbiome of IPMNs has rarely been explored.MethodsTumoral microbiome gene sequencing was carried out using 16 specimens of IPMN and 45 specimens of IPMN with associated invasive carcinoma (IPMN‐IC) by 2bRAD sequencing for microbiome. The profile of the tumoral microbiome was summarized. Associations of the tumoral microbiome with disease grade, histological subtype, and prognosis were analyzed.ResultsA total of 598 species of microbes were identified, comprising 228 genera, 109 families, 60 orders, 29 classes, 14 phyla, and 2 kingdoms. The genus Pseudomonas was detected more frequently and had higher relative abundance in IPMN‐ICs; Alcaligenes faecalis was detected with higher relative abundance in IPMNs. Bifidobacterium pseudolongum had a higher relative abundance in the IPMN‐IC group, regardless of histological subtype. Moreover, among patients with IPMN‐ICs, those with a high relative abundance of B. pseudolongum had better overall survival than those with a low relative abundance. Patients who were positive for Staphylococcus aureus or Mycolicibacillus koreensis had shorter survival. The presence of S. aureus was an independent risk factor for poor prognosis.ConclusionsThere are enriching tumoral microbes in IPMN. The tumoral microbiome of IPMN is different from that of IPMN‐IC.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

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The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: A single‐center retrospective cohort study

Zou,

Mo,

Jia

et al. 2023

J of Gastro and Hepatol

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“…We first characterized the global microbial composition at the phylum, class, order, family, and genus levels of tumor and adjacent normal tissues across 32 cancer types. Consistent with previous studies, the relative abundance of Firmicutes and Fusobacteria significantly enriched tumor tissues, whereas that of Proteobacteria, Actinobacteria, Alphaproteobacteria, and Betaproteobacteria were remarkably predominant in adjacent normal tissues (41)(42)(43)(44)(45)(46)(47). The LEfSe analysis further supported that microbial taxa, including p_Firmicutes/ c_Clostridia, p_Bacteroidetes/c_Bacteroidetes, and p_Fusobacteria/ c_Fusobacteria/o_Fusobacteriales, were tumor-enriched microbes, while p_Actinobacteria/c_Actinobacteria, p_Spirochaetes/ c_Spirochaetes, and p_Proteobacteria/c_Alphaproteobacteria were normal-enriched microbes, suggesting that distinct microbial component in tumor and normal samples, and specific microbes might play an essential role in tumorigenesis and development of cancer.…”

Section: Discussionsupporting

confidence: 90%

Comprehensive analysis of microbiota signature across 32 cancer types

Xia

An²,

He³

et al. 2023

Front. Oncol.

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Microbial communities significantly inhabit the human body. Evidence shows the interaction between the human microbiome and host cells plays a central role in multiple physiological processes and organ microenvironments. However, the majority of related studies focus on gut microbiota or specific tissues/organs, and the component signature of intratumor microbiota across various cancer types remains unclear. Here, we systematically analyzed the correlation between intratumor microbial signature with survival outcomes, genomic features, and immune profiles across 32 cancer types based on the public databases of Bacteria in Cancer (BIC) and The Cancer Genome Atlas (TCGA). Results showed the relative abundance of microbial taxa in tumors compared to normal tissues was observed as particularly noticeable. Survival analysis found that specific candidate microbial taxa were correlated with prognosis across various cancers. Then, a microbial-based scoring system (MS), which was composed of 64 candidate prognostic microbes, was established. Further analyses showed significant differences in survival status, genomic function, and immune profiles among the distinct MS subgroups. Taken together, this study reveals the diversity and complexity of microbiomes in tumors. Classifying cancer into different subtypes based on intratumor microbial signatures might reasonably reflect genomic characteristics, immune features, and survival status.

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“…Fusobacteria were abundant in the intestinal type of invasive main duct IPMNs. These findings suggested that the intratumoral microbiota may be involved in tissue differentiation and the progression of IPMNs [ 92 ]. However, most recent data using cyst fluid obtained intraoperatively indicated that there is no microbiome within IPMNs, and the presence of bacteria within outliner cyst fluid samples is mainly related to prior invasive intervention [ 93 ].…”

Section: The Role Of Inflammation In the Pathogenesis And Malignant P...mentioning

confidence: 99%

Molecular Pathology of Pancreatic Cystic Lesions with a Focus on Malignant Progression

Hu,

Jones,

Esnakula

et al. 2024

Cancers

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The malignant progression of pancreatic cystic lesions (PCLs) remains understudied with a knowledge gap, yet its exploration is pivotal for effectively stratifying patient risk and detecting cancer at its earliest stages. Within this review, we delve into the latest discoveries on the molecular level, revealing insights into the IPMN molecular landscape and revised progression model, associated histologic subtypes, and the role of inflammation in the pathogenesis and malignant progression of IPMN. Low-grade PCLs, particularly IPMNs, can develop into high-grade lesions or invasive carcinoma, underscoring the need for long-term surveillance of these lesions if they are not resected. Although KRAS and GNAS remain the primary oncogenic drivers of neoplastic development in IPMNs, additional genes that are important in tumorigenesis have been recently identified by whole exome sequencing. A more complete understanding of the genes involved in the molecular progression of IPMN is critical for effective monitoring to minimize the risk of malignant progression. Complicating these strategies, IPMNs are also frequently multifocal and multiclonal, as demonstrated by comparative molecular analysis. Algorithms for preoperative cyst sampling and improved radiomic techniques are emerging to model this spatial and temporal genetic heterogeneity better. Here, we review the molecular pathology of PCLs, focusing on changes associated with malignant progression. Developing models of molecular risk stratification in PCLs which can complement radiologic and clinical features, facilitate the early detection of pancreatic cancer, and enable the development of more personalized surveillance and management strategies are summarized.

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Are intratumoral microbiota involved in the progression of intraductal papillary mucinous neoplasms of the pancreas?

Cited by 5 publications

References 30 publications

The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: A single‐center retrospective cohort study

The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: A single‐center retrospective cohort study

Comprehensive analysis of microbiota signature across 32 cancer types

Molecular Pathology of Pancreatic Cystic Lesions with a Focus on Malignant Progression

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