Are nanoparticles potential male reproductive toxicants? A literature review

McAuliffe, Megan; Perry, Melissa J.

doi:10.1080/17435390701675914

Cited by 83 publications

(50 citation statements)

References 10 publications

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“…Nanosilver is also known to show severe toxic effects on the male reproductive system. Research shows that nanosilver can cross the blood-testes barrier and be deposited in the testes where they adversely affect the sperm cells [82]. Even commercially available silver-based dressings have been proved to have cytotoxic effects on various experimental models [83].…”

Section: Toxicity Of Silver Nanoparticlesmentioning

confidence: 99%

Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects

Sukumaran¹,

Poulose²

2012

Int Nano Lett

1,955

1,099

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Silver nanoparticles are nanoparticles of silver which are in the range of 1 and 100 nm in size. Silver nanoparticles have unique properties which help in molecular diagnostics, in therapies, as well as in devices that are used in several medical procedures. The major methods used for silver nanoparticle synthesis are the physical and chemical methods. The problem with the chemical and physical methods is that the synthesis is expensive and can also have toxic substances absorbed onto them. To overcome this, the biological method provides a feasible alternative. The major biological systems involved in this are bacteria, fungi, and plant extracts. The major applications of silver nanoparticles in the medical field include diagnostic applications and therapeutic applications. In most of the therapeutic applications, it is the antimicrobial property that is being majorly explored, though the anti-inflammatory property has its fair share of applications. Though silver nanoparticles are rampantly used in many medical procedures and devices as well as in various biological fields, they have their drawbacks due to nanotoxicity. This review provides a comprehensive view on the mechanism of action, production, applications in the medical field, and the health and environmental concerns that are allegedly caused due to these nanoparticles. The focus is on effective and efficient synthesis of silver nanoparticles while exploring their various prospective applications besides trying to understand the current scenario in the debates on the toxicity concerns these nanoparticles pose.

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Section: Toxicity Of Silver Nanoparticlesmentioning

confidence: 99%

Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects

Sukumaran¹,

Poulose²

2012

Int Nano Lett

1,955

1,099

View full text Add to dashboard Cite

show abstract

“…Previous literature [26] indicated that Ag + causes early changes in the permeability of the cell membrane to K + and then to Na + at concentrations that don't limit Na + , K + -ATP activity. As per the existing literature [27], it has been demonstrated that silver nanoparticles show intensive toxic effects on the proliferation and cytokine expression by peripheral blood mononuclear cells (PMBCs) [28]. Silver does not only cause dermal and cosmetic toxic effects, but also it causes death in animals.…”

Section: Ethical Issues In Nanomedicinementioning

confidence: 99%

The Question of Ethics in Nanomedicine

Kazemi¹,

Majidinia²,

Jamali³

2014

J Clinic Res Bioeth

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Lately, nanotechnology and nanomedicine have achieved tremendous interest and funding, from several entities and directions. Nanomedicine demonstrates great promise for development of medical diagnosis, treatment, and prevention; it also raises various ethical concerns however, there has not been so much study and discussion about social and ethical issues. Nanomaterials are extremely reactive in biological systems owing to the large surface area. Although the benefits of nanomaterials are apparent, there are some studies which show the potential risk to biological systems. Therefore, the rapid progress of nanomedicine and its potentially profound social and environmental impacts is indicative of how the arisen problems could be dangerous and already there are signs that some challenging ethical issues could be raised. In this paper we will examine more recent developments in debates on nanomedicine ethics.

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“…79 Alt et al, however, found that bone cement containing 1.0% nanosilver did not lead to significant cytotoxicity in mouse fibroblasts (L929) and human osteoblast cell line. 61 Although the details of the toxic mechanism are unclear, it suggests that NSPs are ionized in the cells, which leads to activate ion channels and changes the permeability of the cell membrane to both potassium and sodium, 80 interaction with mitochondria, 81 and induction of the apoptosis pathway via the production of reactive oxygen species, 82 which leads to cell death.…”

Section: In Vitro Toxicitymentioning

confidence: 99%

Nanosilver particles in medical applications: synthesis, performance, and toxicity

Ge¹,

Li²,

Wang

et al. 2014

IJN

249

112

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Nanosilver particles (NSPs), are among the most attractive nanomaterials, and have been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. With the increasing application of NSPs in medical contexts, it is becoming necessary for a better understanding of the mechanisms of NSPs’ biological interactions and their potential toxicity. In this review, we first introduce the synthesis routes of NSPs, including physical, chemical, and biological or green synthesis. Then the unique physiochemical properties of NSPs, such as antibacterial, antifungal, antiviral, and anti-inflammatory activity, are discussed in detail. Further, some recent applications of NSPs in prevention, diagnosis, and treatment in medical fields are described. Finally, potential toxicology considerations of NSPs, both in vitro and in vivo, are also addressed.

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Are nanoparticles potential male reproductive toxicants? A literature review

Cited by 83 publications

References 10 publications

Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects

Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects

The Question of Ethics in Nanomedicine

Nanosilver particles in medical applications: synthesis, performance, and toxicity

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