Are poor responders patients at higher risk for producing aneuploid embryos in vitro?

Setti, Amanda Souza; Braga, Daniela Paes de Almeida Ferreira; Figueira, Rita de Cássia Sávio; Azevedo, Matheus de Castro; Iaconelli, Assumpto; Borges, Edson

doi:10.1007/s10815-010-9516-2

Cited by 16 publications

(14 citation statements)

References 36 publications

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“…Further supporting that POR is associated with poor embryo quality, Gianaroli et al (49) reported increased embryo aneuploidy-an age-related marker of poor embryo quality-in women experiencing POR. Conversely, however, other investigators failed to find increased aneuploidy in POR, thus supporting the heterogeneous nature of this condition (50). Data on early pregnancy losses in ART agree with the view that the links between POR and oocyte quality vary according to the category of ART patients in whom it is encountered.…”

Section: Methodssupporting

confidence: 51%

The value of growth hormone supplements in ART for poor ovarian responders

Ziegler

Streuli

Meldrum

et al. 2011

Fertility and Sterility

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Section: Methodssupporting

confidence: 51%

The value of growth hormone supplements in ART for poor ovarian responders

Ziegler

Streuli

Meldrum

et al. 2011

Fertility and Sterility

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“…Patients were divided into two groups according to the number of retrieved oocytes: Poor-responder patients (PR group; patients with≤4 oocytes retrieved) and normoresponder patients (NR group; patients with>4 oocytes retrieved). This criterion has been used in our centre for the characterisation of poor and normal response to controlled ovarian stimulation (COS), and has also been adopted in several published studies [17][18][19][20][21][22][23][24]. Patients who underwent IMSI were matched with patients who underwent ICSI in the same period.…”

Section: Experimental Design Patients and Inclusion Criteriamentioning

confidence: 99%

Poor-responder patients do not benefit from intracytoplasmic morphologically selected sperm injection

Setti

Braga

Figueira

et al. 2015

J Assist Reprod Genet

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Purpose To compare the outcomes of ICSI and IMSI in women presenting with poor ovarian response. Methods Data of IMSI cycles performed from January 2011 to December 2013 were included in this retrospective cohort study. Patients were divided into two groups: normoresponder patients (NR group; patients with>4 oocytes retrieved) and poor-responder patients (PR group; patients with≤4 oocytes retrieved). Patients who underwent IMSI were matched with patients who underwent ICSI in the same period. The ICSI and IMSI outcomes were compared in the NR and PR groups. Results A total of 414 matched cycles were included in this study. The NR group comprised 324 cycles (164 ICSI and 160 IMSI cycles), and the PR group comprised 90 cycles (43 ICSI and 47 IMSI cycles). In the NR group, no significant differences were observed between the ICSI-and IMSI-treated couples regarding cycle outcomes. In the PR group, fertilisation rate was significantly lower in IMSI-treated couples (53.9 %± 36.7 % vs. 79.8 %±29.3 %). The proportion of cycles with embryo transfer (57.4 vs. 79.1 %) and the number of transferred embryos (1.5±0.8 vs. 1.9±0.7) were significantly lower in IMSI compared with ICSI. Implantation, pregnancy and miscarriage rates were similar when ICSI or IMSI were performed. Conclusions Our results suggest that unselected couples undergoing ICSI that present with poor ovarian response to controlled ovarian stimulation do not benefit from sperm selection under high magnification prior to ICSI.

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“…13 There are conflicting data regarding whether compromised ovarian reserve may be associated with an increase in aneuploid pregnancies. [14][15][16][17][18] Comprehensive chromosomal screening is a validated means by which the entire complement of chromosomes within an embryo can be analyzed. [19][20][21] Clinical application of this approach after biopsy of blastocyst stage embryos results in extremely favorable live birth rates after transfer of euploid embryos.…”

Section: Level Of Evidence: IImentioning

confidence: 99%

Association of Abnormal Ovarian Reserve Parameters With a Higher Incidence of Aneuploid Blastocysts

Katz‐Jaffe

Surrey

Minjarez

et al. 2013

Obstetrics & Gynecology

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Are poor responders patients at higher risk for producing aneuploid embryos in vitro?

Abstract: Aged females responding poorly to gonadotrophins are not at a higher risk for producing aneuploid embryos in vitro.

Cited by 16 publications

References 36 publications

The value of growth hormone supplements in ART for poor ovarian responders

The value of growth hormone supplements in ART for poor ovarian responders

Poor-responder patients do not benefit from intracytoplasmic morphologically selected sperm injection

Association of Abnormal Ovarian Reserve Parameters With a Higher Incidence of Aneuploid Blastocysts

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