Are postprandial triglyceride and insulin abnormalities neglected cardiovascular risk factors in type 2 diabetes?

Golay, Alain

doi:10.1046/j.1365-2362.30.s2.3.x

Eur J Clin Investigation

2000

DOI: 10.1046/j.1365-2362.30.s2.3.x

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Are postprandial triglyceride and insulin abnormalities neglected cardiovascular risk factors in type 2 diabetes?

Alain Golay

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2001

2024

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Cited by 8 publications

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The postprandial state does not impair endothelial function in women with Type 2 diabetes irrespective of glycaemic control

et al. 2004

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Aims/hypothesis. The postprandial state has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In Type 2 diabetes, postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the postprandial state. Methods. We studied 19 postmenopausal women with Type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting state, and again 3 hours after a mixed meal (660 kcal, 55% fat). Results. Endothelium-dependent vasodilation was impaired in the diabetic group (p<0.005) and improved following an HbA 1 c reduction of 0.96% (p<0.05 for high-dose acetylcholine infusion). Postprandial metabolic excursions were higher in the diabetic group (p<0.001, p<0.01 and p<0.05 for glucose, insulin and triglycerides respectively). Resting forearm blood flow increased in all groups after the meal (p<0.005). There was no difference in fasting and postprandial endothelium-dependent vasodilation before and after improved glucose regulation in either group. Conclusions/interpretation. The postprandial state does not impair endothelial function in non-diabetic women and does not make pre-existing endothelial dysfunction worse in women with Type 2 diabetes, irrespective of glycaemic control.

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The postprandial state does not impair endothelial function in women with Type 2 diabetes irrespective of glycaemic control

et al. 2004

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A new tactic to treat postprandial hyperlipidemia in diabetic rats with gastroparesis by improving gastrointestinal transit

Xie

Xing

Zhao

et al. 2005

European Journal of Pharmacology

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Hydrogen sulfide donor-based fibrates: Design, synthesis, and evaluation for hypolipidemic activity and hepatoprotection

Sun,

He,

Xie

et al. 2024

Results in Chemistry

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Are postprandial triglyceride and insulin abnormalities neglected cardiovascular risk factors in type 2 diabetes?

Cited by 8 publications

References 50 publications

The postprandial state does not impair endothelial function in women with Type 2 diabetes irrespective of glycaemic control

The postprandial state does not impair endothelial function in women with Type 2 diabetes irrespective of glycaemic control

A new tactic to treat postprandial hyperlipidemia in diabetic rats with gastroparesis by improving gastrointestinal transit

Hydrogen sulfide donor-based fibrates: Design, synthesis, and evaluation for hypolipidemic activity and hepatoprotection

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