Are probiotics a possible treatment of periodontitis? Probiotics against periodontal disease:  a systematic review

Canut-Delgado, Núria; Giovannoni, María Laura; Küstner, Eduardo Chimenos

doi:10.1038/s41415-021-3624-5

Cited by 18 publications

(7 citation statements)

References 38 publications

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“…These all indicate that the balance of intestinal flora can regulate the lipid metabolism process. Similarly, several clinical studies have shown that adjuvant probiotic Lactobacillus reuteri therapy can significantly improve clinical periodontal symptoms after initial periodontal treatment ( 48 ). It has also been found in animal experiments that oral administration of probiotics before and after the formation of periodontitis in mice can significantly reduce the inflammatory factors in periodontitis and relieve alveolar bone resorption and periodontal ligament destruction ( 49 , 50 ).…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization

Hu,

Song,

Yang

et al. 2023

Front. Endocrinol.

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IntroductionThe correlation between dyslipidemia and periodontitis is revealed through epidemiological studies. However, the results are affected by several confounding factors. This study aims to elucidate the genetic causal association between circulating lipid traits and periodontitis by two-sample Mendelian randomization (MR) analysis.MethodsAfter the different screening processes, two cohorts of circulating lipid traits from the UK Biobank were used as exposure data, including five circulating lipid traits. The Periodontitis cohort was selected from the GeneLifestyle Interactions in Dental Endpoints (GLIDE) consortium as outcome data. In univariable MR, the inverse variance weighted (IVW) was used in conjunction with six additional analytical methods to assess causality. The Cochran Q test, IGX2 statistic, MR-PRESSO, and MR-Egger intercept were used to quantify heterogeneity and pleiotropy. The multivariable MR-IVW (MVMR-IVW) and MVMR-robust were mainly used as analytical methods in the multiple MR analyses.ResultsThe IVW estimates showed that genetically predicted Apolipoprotein A1 (apo A1) [odds ratio (OR)=1.158, 95% confidence interval (CI)=1.007–1.331, P-value=0.040] was potentially associated with the risk of periodontitis, but the statistical power of the results was low. Multivariable MR analysis did not reveal any significant causal relationship between apo A1 and periodontitis (OR=0.72, 95% CI=0.36–1.41, P-value=0.34). In the validation cohort, there was also no significant causal relationship between apo A1 and periodontitis (OR=1.079, 95% CI=0.903–1.290, P-value=0.401). Meanwhile, genetically predicted Apolipoprotein B (apo B), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) (all P-values>0.05) were not significantly associated with the risk of periodontitis causal inference.ConclusionThis MR analysis was unable to provide genetic evidence for the influence of these five circulating lipid traits on periodontitis. However, a more extensive study with a more comprehensive circulating lipid profile and periodontitis data is needed due to study limitations.

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Section: Discussionmentioning

confidence: 99%

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization

Hu,

Song,

Yang

et al. 2023

Front. Endocrinol.

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“…Studies evaluating the effects of probiotics on dental health suggest Lactobacillus rhamnosus might be useful in the prevention of dental caries: long-term consumption of milk containing Lactobacillus rhamnosus GG, ATCC (LGG) has been demonstrated to reduce the risk of caries in children (1–6 years) and short-term consumption of cheese containing L. rhamnosus GG ATCC 53103 and L. rhamnosus LC 705 can reduce the counts of Streptococcus mutans and salivary yeasts in young adults (18–35 years, mean age 24.5 years) [ 121 , 122 ]. Furthermore, probiotics have been shown to have the potential to alter the sub-gingival microbiota’s composition, significantly reducing the concentration of the main periodontal pathogens [ 123 ]. Lactobacilli and Streptococci strains have been shown to possess antibacterial activity against known periodontal bacteria like P. gingivalis , Prevotella intermedia , Aggregatibacter actinomycetemcomitans and F. nucleatum in vitro studies [ 124 ], therefore they could be a potential adjuvant in treatments for periodontal disease as also concluded by A. Vives-Soler and E. Chimenos-Küstner after a systematic analysis of the available data [ 125 ].…”

Section: Role Of Probiotics Against Dysbiosismentioning

confidence: 99%

A Reciprocal Link between Oral, Gut Microbiota during Periodontitis: The Potential Role of Probiotics in Reducing Dysbiosis-Induced Inflammation

Stefano

Santonocito

Polizzi

et al. 2023

IJMS

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Human body is colonized by a florid microbial community of bacteria, archaea, fungi, protists, helminths, and viruses, known as microbiota, which co-evolves with the host and influences its health through all stages of its life. It is well known that oral microorganisms form highly structurally and functionally organized multi-species biofilms and establish a network of complex mutual inter-species interactions having a primary function in synergy, signaling, or antagonism. This ecological model allows the microorganisms to increase their resistance to antimicrobial agents and settle a balanced microbes-host symbiotic relationship that ensures oral and global health status in humans. The host-associated microbiome is an important factor in human health and disease. Therefore, to develop novel diagnostic, therapeutic, and preventive strategies, microbiome’s functions and the reciprocal interactions every microbiome entertains with other microbial communities in the human body are being investigated. This review provides an analysis of the literature about the close connection between the two largest microbial communities in humans: the oral and the gut microbiomes. Furthermore, it focuses on how the alteration of their microbial and functional characteristics can lead to and reciprocally influence the onset of both oral and intestinal microbiome-associated illness, along with the potential role of probiotics in ameliorating inflammation and microbial dysbiosis.

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“…Die Entzündungen des Zahnfleisches und Zahnhalteapparates sollten ebenfalls unbedingt therapiert werden, denn sie bedeuten neben dem Risiko eines Zahnverlustes auch ein höheres Diabetes- und Frühgeburtsrisiko. Aus ganzheitlicher Sicht kann das Biofilmmanagement (die Reduktion der Anzahl der pathogenen Flora durch die professionelle Zahnreinigung) zum Beispiel durch die Gabe von Präbiotika und Probiotika, Ernährungsumstellung auf leichte mediterrane, zuckerfreie Kost, Entspannungs- und Bewegungstechniken (Achtsamkeitsübungen, Yoga, Qi Gong), Orthomolekular-Therapie (Vitamin A, B, C, D, E, Q10, Calcium, Magnesium, Zink, Selen, Omega-3-Fettsäuren) und Phytotherapie (Kamille, Salbei) ergänzt werden 4 5 7 8 .…”

Section: Schwangerschaftunclassified

Gesund beginnt im Mund: Zahngesundheit bei Kindern

Nadj-Papp¹

2023

Zeitschrift für Komplementärmedizin

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SummaryMundgesundheit beginnt bereits im Mutterleib. Zahnprobleme der Mutter während der Schwangerschaft können sich auf das Ungeborene auswirken. Bei Babys und Kindern nehmen dann das Stillen, die Ernährung, aber auch das Benutzen eines Schnullers wesentlichen Einfluss auf die Zähne. Wichtig ist eine konsequente Zahnpflege ab dem Durchbruch des ersten Zahns. Experten empfehlen, Kinder bereits ab dem 6. Lebensmonat zahnmedizinisch zu begleiten. Versiegelungen, Füllungen und Kronen sind wichtige Maßnahmen bei Zahnproblemen – auch bei Kindern.

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Are probiotics a possible treatment of periodontitis? Probiotics against periodontal disease: a systematic review

Cited by 18 publications

References 38 publications

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization

A Reciprocal Link between Oral, Gut Microbiota during Periodontitis: The Potential Role of Probiotics in Reducing Dysbiosis-Induced Inflammation

Gesund beginnt im Mund: Zahngesundheit bei Kindern

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