Are progranulin levels associated with polycystic ovary syndrome and its possible metabolic effects in adolescents and young women?

Ersoy, Ali Özgür; Tokmak, Aytekin; Özler, Sibel; Öztaş, Efser; Ersoy, Ebru; Çelik, Hüseyin; Erdamar, Husamettin; Yılmaz, Nafiye

doi:10.1007/s00404-016-4096-8

Cited by 9 publications

(4 citation statements)

References 27 publications

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“…It is known that insulin resistance plays an important role in PCOS pathophysiology. In a recent study from Turkey, higher progranulin levels in women with PCOS were found compared with non-PCOS patients [19]. The authors proposed that cysteine-rich growth factors like progranulin may cause excessive early follicular growth as androgens.…”

Section: Discussionmentioning

confidence: 99%

The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status

Kan

Görkem

2019

Endokrynologia Polska

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Introduction: Granulin (GRN) is an adipokine with proinflammatory features, which plays important role in glucose metabolism and insulin resistance pathogenesis. It has been reported that granulin precursors were localised in developing follicles in animal studies. The purpose of this study was to evaluate the association of granulin levels with anthropometric features, glucose metabolism, and ovarian reserve. Material and methods: A total of 109 infertile women were included in this cross-sectional, prospective study, who attended a tertiary clinic. All participants were categorised into diminished ovarian reserve (DOR) and normal ovarian reserve groups (NOR), in accordance with Bologna criteria. The demographic characteristics, including age, BMI, waist-hip circumferences, and biochemical parameters, were recorded. Serum granulin level was determined by enzyme-linked immunosorbent assay. Results: No significant difference was observed in the GRN levels (p = 0.229) between the groups. There was a positive correlation between GRN levels and BMI, WC, HC, and 75 g oral glucose tolerance values in NOR group (p < 0.01, p < 0.05, p < 0.01, and p < 0.05, respectively). Conclusions: Our results suggest that granulin is associated with anthropometric features in infertile patients and might be an important indicator of obesity and impaired glucose metabolism. Elevated levels of granulin may have a diabetogenic effect and predispose women to high glucose levels.

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Section: Discussionmentioning

confidence: 99%

The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status

Kan

Görkem

2019

Endokrynologia Polska

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“…In our research, in agreement with Moran et al [ 27 ], we found no differences in the DHEAS levels in women with PCOS with different BMIs. DHEA appears to have a positive effect on antral follicle number and ovarian volume in women undergoing assisted reproduction for primary failure [ 28 ]. Although approximately 40–70% of women with PCOS have elevated levels of DHEA-S, the correlation between DHEA-S level and the biochemical parameters of PCOS has not been thoroughly investigated [ 5 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Levels of Trace Elements in Erythrocytes as Endocrine Disruptors in Obese and Nonobese Women with Polycystic Ovary Syndrome

Pokorska-Niewiada

Brodowska

Brodowski

2022

IJERPH

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Introduction: Polycystic ovary syndrome (PCOS) is one of the most commonly recognized endocrinopathies in women. The literature lacks clear data that allow any meaningful conclusions to be drawn about the influence of trace elements in erythrocytes on the biochemical parameters of PCOS. Materials and methods: This study was conducted among 47 women meeting the Rotterdam criteria for the diagnosis of polycystic ovary syndrome. The research groups included women with PCOS with different BMI values (body mass index): obese women with PCOS (PCOS with BMI ≥ 30, mean BMI index 35.4 ± 4.4 kg/m2), nonobese PCOS women (PCOS with BMI < 30, mean BMI index 25.2 ± 2.8 kg/m2), and healthy control group (CG) with a mean BMI of 23.57 ± 0.9 kg/m2. The contents of trace elements in erythrocytes were determined with an inductively coupled plasma atomic emission spectrometer. Results: The only trace element showing significant differences in concentration between the studied groups was nickel (Ni). The level of nickel in the obese women with PCOS (BMI ≥ 30) was significantly higher than in nonobese women (BMI < 30). The content of other trace elements in erythrocytes did not differ significantly between the studied groups. Several significant correlations were found within each of the studied PCOS groups: in the group of obese women, the content of zinc (Zn) in erythrocytes positively correlated with prolactin, the content of magnesium (Mg) positively correlated with testosterone, and the content of manganese (Mn) negatively correlated with thyroid-stimulating hormone. In the group of nonobese women, Zn content correlated positively with testosterone, Ni with luteinizing hormone (LH) and estradiol, and Mg negatively correlated with estradiol. Conclusions: The relationship between the level of trace elements and the level of hormones suggests that, in obese women with PCOS, nickel may play a role in inhibiting the processes of folliculogenesis and ovulation. Research on trace elements and their relationship to ovulatory cycles and the development of PCOS may contribute to reducing the consequences of PCOS and, therefore, should be extended.

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“…Considering low HDL-C levels are a strong predictor of future cardiac events, progranulin might be used as a cardiovascular risk biomarker. 30 …”

Section: Metabolic Factorsmentioning

confidence: 99%

Polycystic Ovary Syndrome in Adolescence: Challenges in Diagnosis and Management

Manique

Póvoa

2022

Rev Bras Ginecol Obstet

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Diagnosing polycystic ovary syndrome (PCOS) during adolescence is challenging since normal pubertal development overlap typical features of this syndrome. The authors aim to summarize the existing evidence concerning PCOS in adolescence, particularly its diagnostic criteria and therapeutic options. A search throughout medical databases such as PubMed and MedScape was performed. Diagnostic criteria include irregular menstrual cycles according to time postmenarche and evidence of clinical hyperandrogenism and/or biochemical hyperandrogenism, provided other causes have been excluded. Polycystic ovarian morphology ought not to be used as a diagnostic criterion. Treatment should target manifestations and/or comorbidities, even in the absence of a definite diagnosis. Lifestyle interventions are the first-line treatment. Combined oral contraceptives, metformin or antiandrogens may also be considered as adjuvants. Screening for PCOS in adolescence is crucial as it allows an early intervention on the symptoms and comorbidities presented leading to better long-term reproductive and metabolic outcomes.

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Are progranulin levels associated with polycystic ovary syndrome and its possible metabolic effects in adolescents and young women?

Abstract: Progranulin may be a novel biomarker for cardiovascular risk in patients with PCOS, thus these cases should be directed to close follow-up for possible cardiovascular diseases. Future larger studies should focus on this entity.

Cited by 9 publications

References 27 publications

The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status

The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status

Levels of Trace Elements in Erythrocytes as Endocrine Disruptors in Obese and Nonobese Women with Polycystic Ovary Syndrome

Polycystic Ovary Syndrome in Adolescence: Challenges in Diagnosis and Management

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