“…2 However, more efficiency in scientific publication did manifest in accelerated publication, [6][7][8] journals tearing down their paywalls for their COVID-19 output, 14 an increased usage of life and medical sciences preprint servers to increase speed and transparency, 15 not to mention the intense international collaboration that resulted in the development of multiple high-efficacy vaccines within the first year of the pandemic. 16 On the other hand, some pratices that reduce the reliability of clinical trials may have gained some traction during 2020, such as executing underpowered studies with small samples, multiplicity of trials testing ideas with low prior probability of being true, forgoing blinding to test interventions 10 11 14 17-20 and incomplete reporting of findings, which was already an issue before the pandemic. 12 21 To what extent that has dominated the general output in medical interventions for COVID-19 and how much of it turned into actual clinical pratice is something that has not yet been thoroughly assessed and is, thus, still open for debate.…”