Are the clinical manifestations of CT scan and location associated with World Health Organization histopathological grades of meningioma?: A retrospective study

Behzadmehr, Razieh; Behzadmehr, Rezvaneh

doi:10.1016/j.amsu.2021.102365

Cited by 4 publications

(10 citation statements)

References 27 publications

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“…However, the resulting prognostic factors of parasagital meningioma recurrence/continued growth in this study are consistent with the data from known literature sources (Behzadmehr et al, 2021, Balik et al, 2020, Cucu et al, 2020, Salah et al, 2019, Siempis et al, 2020. However, we found that recurrence-free 5-and 10-year survival in PM patients is as follows: 1) in case of total tumor removal (Simpson I), 96.0% and 85.5%, respectively; in case of non-radical removal (Simpson II-V), 88.9% (p<0.05) and 81.9% (p<0.05), respectively.…”

Section: Ukrainian Scientific Medical Youth Journalsupporting

confidence: 91%

“…After radical (Simpson I) removal of parasagital meningioma as low as 1% of patients have any recurrence; after a substantially total removal (Simpson I-II), 12.2%; and after subtotal removal (Simpson III-V), up to 24% (Behzadmehr et al, 2021, Cucu et al, 2020.…”

Section: Introductionmentioning

confidence: 99%

“…Such factors, particularly, include neoplasm volume, which in almost 70% of cases exceed the average value. In some studies, (Nakasu et al, 2020, Siempis et al, 2020, almost 100% of recurrences had fuzzy edges of meningioma on magnetic resonance imaging, while other researchers reported no such association (Behzadmehr et al, 2021, Balik et al, 2020. In addition, it is reported that the majority of patients (61.5%) with recurrent meningioma experienced severe perifocal brain edema (Nakasu et al, 2020, Siempis et al, 2020.…”

Section: Introductionmentioning

confidence: 99%

“…According to existing studies, parasagital meningiomas are more likely to recur/continue growing than meningiomas in other areas (18% to 40%). Low-grade meningiomas are the most common parasagital meningiomas (Behzadmehr et al, 2021, Balik et al, 2020, Cucu et al, 2020. Topographic and anatomical tumor connections with the surrounding intracranial structures is the key problem in trying to prevent the recurrence.…”

Section: Introductionmentioning

confidence: 99%

“…Based on 7 studies, the WHO's grade I parasagital meningioma recurs, in average, in 11.4% of patients; WHO's grade II, in 25% to 55.1% of patients. Moderate-to lowgrade meningiomas (grades II-III) recur in up to 61% of patients (Behzadmehr et al, 2021, Balik et al, 2020.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Factors for Parasagital Meningiomas Recurrence

Perepelytsia¹,

Sirko

2023

USMYJ

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the study is relevant due to high prevalence of this type of pathology. Meningiomas account for 18% to 34% of all primary brain tumors. Parasagital meningiomas occur in 24.3% to 38.6% of cases. Despite their predominantly benign nature, parasagital meningiomas are more likely to recur/continue growing than meningiomas in other areas (18% to 40%). The key purpose of the study was to analyze the prognostic factors of parasagital meningiomas recurrence/continued growth, which will eventually improve surgical treatment outcomes. We conducted a retrospective and prospective analysis of 199 parasagital meningioma patients who were treated in Mechnikov Dnipropetrovsk Regional Clinical Hospital, Dnipropetrovsk Regional Council, from 2000 to 2021 inclusive. This article is based on a comparative analysis of the results of examination and surgical treatment and further analysis of pathohistological conclusion in two study groups. The first group included 180 (90.5%) patients with no recurrence/continued growth and second group included 19 (9.5%) patients with detected postoperative parasagital meningioma (PM) recurrence/continued growth. The selected patients were analyzed for demographic data (gender, age); computed tomography and magnetic resonance brain imaging results before and after adding an intravenous contrast (in terms of key characteristics); angiographic studies data (computed tomography angiography/selective digital subtraction cerebral angiography); surgical radicality; pathohistological conclusions; recurrence-free period duration (one to 20 years after the surgery). In the follow-up period, 19 (9.5%) patients had PM recurrence/continued growth. In the first year after the surgery, only 2 of those patients had continued PM growth; within 5 years (60 months), 12 patients; within 10 years, 17 patients; the percentage of no- recurrence patients, based on censored data (recurrence-free survival), was 99.0% (95% CI, 97,6-100), 93,1% (95% CI, 89.3-96.9). and 87.5% (95% CI, 81.6-93.4) in the above follow-up periods. The actual median time to recurrence in our study was 44.1 (25.7; 85.4) months. It means that the majority (12 of 19 patients; 63.2%) of continued PM growth was detected within 5 years after the surgery. The last case of PM recurrence was diagnosed after 13 years (154.5 months) of the follow-up. Thus, recurrence-free 5- and 10-year survival in PM patients is as follows: in case of total tumor removal (Simpson I), 96.0% and 85.5%, respectively; in case of non-radical removal (Simpson II-V), 88.9% (p<0.05) and 81.9% (p<0.05), respectively. At the same time, non-radical surgery in type I-II SSS invasion by the PM reduces 5- and 10-year recurrence-free survival to 86.6% (p<0.01) and 78.3% (p<0.01), respectively; in case of tumor size of up to 54 mm, the indicators are 95.5% and 91.4%; with tumor size >54 mm, they are as low as 87.5% (p<0.001) and 72.5% (p<0.001); in case of type I-III or V-VI SSS damage according to M. P. Sindou and J. E. Alvernia, 94.0% and 89.1%; and in case of type IV invasion, 66.5% (p<0.01) and 43.5% (p<0.001); in female patients, 95.2% and 88.5%; in male patients, 84.8% (p<0.05) and 73.0% (p<0.01). According to the Cox regression proportional hazards model, the relative risk of tumor recurrence/continued growth increases by: 7.04 times (95% CI, 2.33-21.2) in case of initial PM size >54 mm (p<0.001); 5.57 times (95% CI, 1.27-24.34) in case of non-radical (Simpson II-V) tumor removal during primary intervention (P<0.05); 10.1 times (95% CI, 1.31-78.1) in case of type I-II SSS invasion by the PM or incomplete (Simpson II-V) tumor removal (p<0.05); 3.25 times (95% CI, 1.32-8.02) in male patients (p<0.01); 3.33 times (95% CI, 1.10-10.12) in case of type IV SSS invasion (according to M.P. Sindou and J.E. Alvernia) (p<0.05). Adequate analysis of the results obtained will help the neurosurgeons plan the optimal surgery volume and ensure further postoperative recurrence-free period and improved long-term treatment outcomes.

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Section: Ukrainian Scientific Medical Youth Journalsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic Factors for Parasagital Meningiomas Recurrence

Perepelytsia¹,

Sirko

2023

USMYJ

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Principal component analysis of texture features for grading of meningioma: not effective from the peritumoral area but effective from the tumor area

Mori

Mugikura²,

Endo³

et al. 2022

Neuroradiology

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Meningioma grading via diagnostic imaging: A systematic review and meta-analysis

Upreti,

Dube,

Pareek

et al. 2024

Neuroradiology

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Purpose Meningioma is the most common intracranial tumor, graded on pathology using WHO criteria to predict tumor course and treatment. However, pathological grading via biopsy may not be possible in cases with poor surgical access due to tumor location. Therefore, our systematic review aims to evaluate whether diagnostic imaging features can differentiate high grade (HG) from low grade (LG) meningiomas as an alternative to pathological grading. Methods Three databases were searched for primary studies that either use routine magnetic resonance imaging (MRI) or computed tomography (CT) to assess pathologically WHO-graded meningiomas. Two investigators independently screened and extracted data from included studies. Results 24 studies met our inclusion criteria with 12 significant (p < 0.05) CT and MRI features identified for differentiating HG from LG meningiomas. Cystic changes in the tumor had the highest specificity (93.4%) and irregular tumor-brain interface had the highest positive predictive value (65.0%). Mass effect had the highest sensitivity (81.0%) and negative predictive value (90.7%) of all imaging features. Imaging feature with the highest accuracy for identifying HG disease was irregular tumor-brain interface (79.7%). Irregular tumor-brain interface and heterogenous tumor enhancement had the highest AUC values of 0.788 and 0.703, respectively. Conclusion Our systematic review highlight imaging features that can help differentiate HG from LG meningiomas.

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Are the clinical manifestations of CT scan and location associated with World Health Organization histopathological grades of meningioma?: A retrospective study

Cited by 4 publications

References 27 publications

Prognostic Factors for Parasagital Meningiomas Recurrence

Prognostic Factors for Parasagital Meningiomas Recurrence

Principal component analysis of texture features for grading of meningioma: not effective from the peritumoral area but effective from the tumor area

Meningioma grading via diagnostic imaging: A systematic review and meta-analysis

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