Are the thiol/disulfide redox status and HDL cholesterol levels associated with pulmonary embolism?

Parlak, Ebru; Alışık, Murat; Karalezli, Ayşegül; Sayilir, Ayse Gokcen; Baştuğ, Serdal; Er, Mükremin; Hasanoğlu, H. Canan; Erel, Özcan

doi:10.1016/j.clinbiochem.2017.07.018

Cited by 8 publications

(8 citation statements)

References 29 publications

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“…Additionally, we also found a significant correlation between HDL, BUN levels and total, native thiol levels. This correlation was also found in other studies with similar method [29,35,36].…”

Section: Discussionsupporting

confidence: 89%

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Baykan

Bıçer

Gerçeker³

et al. 2019

The European Research Journal

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Objectives:The aim of the study was to evaluate the oxidative stress level in patients, diagnosed with H. pylori infection, using a novel marker (thiol/disulphide homeostasis) and to compare the level in infected individuals with that in healthy volunteers. Methods: A total of 60 patients diagnosed with gastritis, erosive gastritis or ulcer by endoscopy were included and biopsied. The 30 patients diagnosed with H. pylori and 30 healthy individuals were enrolled. Medical histories, physical examination results, body mass index (BMI), hemogram, free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), urea, creatinin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein) LDL and thiol/disulphide levels obtained in the study groups were compared. Results: There was no significant difference between the total thiol, native thiol, disulphide/native thiol and dissulphide/total thiol ratios of the patient and control group. When the H. pylori patients were stratified by endoscopic evaluation as having mild (superficial gastritis or normal appearance) or severe (ulcer or erosive areas) symptoms, there were significant differences in disulphide, disulphide/native thiol, disulphide/total thiol and native thiol/total thiol levels. We also observed BMI and the total, native thiol levels of H. pylori patients were inversely related.( r: 0.562, p = 0.001; r: 0.0552, p = 0.002). Conclusions: Thiol/disulphide homeostasis is likely to differ with both duration and severity of H. pylori infection. Further investigations are needed to investigate the effect of H. pylori on oxidative stress.

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Section: Discussionsupporting

confidence: 89%

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Baykan

Bıçer

Gerçeker³

et al. 2019

The European Research Journal

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“…In acute pulmonary embolism and childhood asthma patients, it has been established that disulfide level and disulfide to NT ratio of patient group were found to be higher compared to control group [49,50]. Contrarily, in chronic obstructive pulmonary disease, asthma and asthma-chronic obstructive pulmonary disease overlap syndrome patients, TDH parameters were found similar among three groups.…”

Section: Respiratory System Diseasesmentioning

confidence: 87%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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“…The potential vasoprotective mechanisms of HDL in pulmonary circulation have been reviewed. 45 In our study, we measured the plasma total levels of cholesterol, which were found to be increased in PAH patients compared to the controls.…”

Section: Discussionmentioning

confidence: 96%

Metabolomics Meets Clinics: A Multivariate Analysis of Plasma and Urine Metabolic Signatures in Pulmonary Arterial Hypertension

Wawrzyniak,

Grešner,

Lewicka

et al. 2023

J. Proteome Res.

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Pulmonary arterial hypertension (PAH) is a severe, multifactorial, and frequently misdiagnosed disorder. The aim of this observational study was to compare the plasma and urine metabolomic profiles of PAH patients and healthy control subjects. Plasma and urine metabolomic profiles were analyzed using the GC-MS technique. Correlations between metabolite levels and clinical parameters among PAH patients, as well as the between-group differences, were evaluated. The linear discriminant analysis model, which allows for subject classification in terms of PAH with the highest possible precision, was developed and proposed. Plasma pyruvic acid, cholesterol, threonine, urine 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid, butyric acid, 1,2-benzenediol, glucoheptonic acid, and 2-oxo-glutaric acid were found to build a relatively accurate classification model for PAH patients. The model reached an accuracy of 91% and significantly improved subject classification (OR = 119 [95% CI: 20.3–698.3], p < 0.0001). Five metabolites were detected in urine that provide easily available and noninvasive tests as compared to right heart catheterization. The selected panel of metabolites has potential for early recognition of patients with dyspnea and faster referral to a reference center.

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Are the thiol/disulfide redox status and HDL cholesterol levels associated with pulmonary embolism?

Cited by 8 publications

References 29 publications

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Metabolomics Meets Clinics: A Multivariate Analysis of Plasma and Urine Metabolic Signatures in Pulmonary Arterial Hypertension

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