Are tissue samples from two different anatomical areas of the kidney necessary for adequate diagnosis?

Gerth, Jens; Busch, Martin; Illner, N.; Traut, M.; Gröne, H. J.; Wolf, Günter

doi:10.5414/cnp74258

Cited by 14 publications

(9 citation statements)

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“…An outline of the necessary elements required for an adequate renal biopsy is well described in a review by Fogo. 10 A renal biopsy should include at least 10 glomeruli, 11 although 420 may be needed to diagnose a focal glomerular disease. 12 The minimum sample size for diagnosis varies greatly depending on the underlying diagnosis.…”

Section: Technicalities Of Renal Biopsymentioning

confidence: 99%

Utility of renal biopsy in the clinical management of renal disease

Dhaun

Bellamy

Cattran

et al. 2014

Kidney International

129

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Characterizing chronic kidney disease (CKD) at all stages is an essential part of rational management and the renal biopsy plays a key role in defining the processes involved. There remain no global guidelines available to the renal community on indications for this important diagnostic, prognostic, and relatively safe test. Although most nephrologists recognize several clear indications for a renal biopsy, it is still underutilized. It not only helps the clinician to manage the patient with CKD, but it can also help clarify the epidemiology of CKD, and aid research into the pathobiology of disease with the aim of discovering new therapies. It may be useful for instance in elderly patients with CKD, those with diabetes and presumed 'hypertensive nephropathy', and in some patients with advanced CKD as part of the pretransplant work-up. In some populations (for example, immunoglobulin A nephropathy and ANCA vasculitis), renal biopsy allows disease classification that may predict CKD progression and response to therapy. For the individual, interval renal biopsy may be of use in providing ongoing therapeutic and prognostic information. Molecular advances will change the landscape of renal pathology and add a new dimension to the diagnostic precision of kidney biopsy. Organizing the multiplicity of information available in a renal biopsy to maximize benefits to the patient, as well as to the epidemiologist and researcher, is one of the challenges that face the nephrology community.

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Section: Technicalities Of Renal Biopsymentioning

confidence: 99%

Utility of renal biopsy in the clinical management of renal disease

Dhaun

Bellamy

Cattran

et al. 2014

Kidney International

129

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“…On the contrary, one study comparing two biopsy cores from various kidney locations showed no significant sampling error, suggesting that such a bias might not be as relevant as is often anticipated. 157 In renal biopsy diagnostic, the degree of interstitial fibrosis is assessed on routinely performed stains, preferentially on special stains for ECM, such as the Sirius red or Masson's trichrome stain. Immunohistochemistry or immunofluorescence can be used for a more specific assessment of particular ECM components (Fig.…”

Section: Renal Ecm Components-biomarker Potential?mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold

Bülow

Boor

2019

J Histochem Cytochem.

278

187

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Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases (CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all other organs, is pathological deposition of extracellular matrix (ECM). Renal ECM is a complex network of collagens, elastin, and several glycoproteins and proteoglycans forming basal membranes and interstitial space. Several ECM functions beyond providing a scaffold and organ stability are being increasingly recognized, for example, in inflammation. ECM composition is determined by the function of each of the histological compartments of the kidney, that is, glomeruli, tubulo-interstitium, and vessels. Renal ECM is a dynamic structure undergoing remodeling, particularly during fibrosis. From a clinical perspective, ECM proteins are directly involved in several rare renal diseases and indirectly in CKD progression during renal fibrosis. ECM proteins could serve as specific non-invasive biomarkers of fibrosis and scaffolds in regenerative medicine. The gold standard and currently only specific means to measure renal fibrosis is renal biopsy, but new diagnostic approaches are appearing. Here, we discuss the localization, function, and remodeling of major renal ECM components in healthy and diseased, fibrotic kidneys and the potential use of ECM in diagnostics of renal fibrosis and in tissue engineering.

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“…Few studies have compared two different biopsy cores to determine whether sampling error is a significant issue. At least one study offers reassurance that this is not the case (361). Protocol biopsies of the renal allograft may also provide important sequential information on renal fibrosis, in particular when evaluated quantitatively (362)(363)(364).…”

Section: Diagnosis Of Renal Fibrosismentioning

confidence: 99%

Renal Allograft Fibrosis: Biology and Therapeutic Targets

Floege

2015

American Journal of Transplantation

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Are tissue samples from two different anatomical areas of the kidney necessary for adequate diagnosis?

Cited by 14 publications

References 0 publications

Utility of renal biopsy in the clinical management of renal disease

Utility of renal biopsy in the clinical management of renal disease

Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold

Renal Allograft Fibrosis: Biology and Therapeutic Targets

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