Are Unilateral Right Posterior Cerebral Lesions Sufficient to Cause Prosopagnosia? Clinical and Radiological Findings in Six Additional Patients

Landis, Théodor; Cummings, Jeffrey L.; Christen, Lisanne; Bogen, Joseph E.; Imhof, Hans-Georg

doi:10.1016/s0010-9452(86)80048-x

Cited by 210 publications

(87 citation statements)

References 14 publications

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“…In a study requiring the explicit processing of facial identity and emotion, activations were noted in the right fusiform gyrus in the identity condition and in the cingulate in the emotion condition but much more caudal to the focus identified in the present study (Sergent et al, 1994). Our finding of unilateral activation in the right fusiform gyrus, however, is consistent with evidence that impaired facial recognition may also be seen after unilateral right temporal lobe lesions (De Renzi, 1996;Landis et al, 1986).…”

Section: Discussionsupporting

confidence: 84%

Neural Activation during Covert Processing of Positive Emotional Facial Expressions

et al. 1996

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Lesion studies indicate distinct neural systems for recognition of facial identity and emotion. Split-brain experiments also suggest that emotional evaluation of a stimulus can occur without conscious identification. The present study tested a hypothesis of a differential neural response, independent of explicit conscious mediation, to emotional compared to nonemotional faces. The experimental paradigm involved holding in mind an image of a face across a 45-s delay while regional cerebral blood flow was measured using positron emission tomography. Prior to the delay, a single face was presented with an explicit instruction to match it to one of two faces, photographed at different angles from the target face, presented at the end of the delay. Repeated blood flow measures were obtained while subjects held happy or neutral faces in mind or during a neutral control fixation condition without initial face presentation. The representation of emotional faces over a delay period, compared to either the nonemotional or the fixation condition, was associated with significant activation in the left ventral prefrontal cortex, the left anterior cingulate cortex, and the right fusiform gyrus. The findings support our hypothesis of a differential neural response to facial emotion, independent of conscious mediation, in regions implicated in the processing of faces and of emotions. r 1996 Academic Press, Inc.

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Section: Discussionsupporting

confidence: 84%

Neural Activation during Covert Processing of Positive Emotional Facial Expressions

et al. 1996

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“…Neuropsychological studies of patients with prosopagnosia (Hecaen and Angelergues 1962;McNeil and Warrington 1993), a selective impairment of the ability to recognize familiar faces with relatively intact ability to recognize other objects, suggested a dissociation between neural systems that mediate face and object recognition. The lesions that cause prosopagnosia are found in ventral occipitotemporal cortex and are usually bilateral (Benton 1980;Damasio et al 1982;Sergent and Signoret 1992), although right unilateral lesions have been the cause of this syndrome in a few well-documented cases (De Renzi 1986;Landis et al 1986).…”

Section: Extrastriate Visual Cortex and Face Perception: The Core Systemmentioning

confidence: 99%

Human neural systems for face recognition and social communication

Haxby

Hoffman

Gobbini

2002

Biological Psychiatry

1,137

824

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“…Initial studies indicated that lesions within parietooccipital cortical regions were responsible (Benton & Van Allen, 1972), but more recent studies have demonstrated that prosopagnosia is prevalent following lesions in the inferior occiptotemporal region (Damasio, Damasio, & Van Hoesen, 1982;Meadows, 1974). Although frequently observed with bilateral damage (e.g., Damasio et al, 1982;Nardelli, Buananno, Coccia, Fiaschi, Terzian, & Rizzuto, 1982), there is evidence that prosopagnosia may occur following unilateral damage to the right, but not the left, cerebral hemisphere (De Renzi, 1986;Landis, Cummings, Christen, Bogen, & Imhof, 1986;Michel, Poncet, & Signoret, 1989).…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological Studies of Face Perception in Humans

Bentin

Allison²,

Puce

et al. 1996

Journal of Cognitive Neuroscience

2,755

287

2,305

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Event-related potentials (ERPs) associated with face perception were recorded with scalp electrodes from normal volunteers. Subjects performed a visual target detection task in which they mentally counted the number of occurrences of pictorial stimuli from a designated category such us butterflies. In separate experiments, target stimuli were embedded within a series of other stimuli including unfamiliar human faces and isolated face components, inverted faces, distorted faces, animal faces, and other nonface stimuli. Unman faces evoked a negative potential at 172 msec (N170), which was absent from the ERPs elicited by other animate and inanimate nonface stimuli. N170 was largest over the posterior temporal scalp and was larger over the right than the left hemisphere. N170 was delayed when faces were presented upside-down, but its amplitude did not change. When presented in isolation, eyes elicited an N170 that was significantly larger than that elicited by whole faces, while noses and lips elicited small negative ERPs about 50 msec later than N170. Distorted human faces, in which the locations of inner face components were altered, elicited an N170 similar in amplitude to that elicited by normal faces. However, faces of animals, human hands, cars, and items of furniture did not evoke N170. N170 may reflect the operation of a neural mechanism tuned to detect (as opposed to identify) human faces, similar to the "structural encoder" suggested by Bruce and Young (1986). A similar function has been proposed for the face-selective N200 ERP recorded from the middle fusiform and posterior inferior temporal gyri using subdural electrodes in humans (Allison, McCarthy, Nobre, Puce, & Belger, 1994c). However, the differential sensitivity of N170 to eyes in isolation suggests that N170 may reflect the activation of an eye-sensitive region of cortex. The voltage distribution of N170 over the scalp is consistent with a neural generator located in the occipitotemporal sulcus lateral to the fusiform/inferior temporal region that generates N200.

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Are Unilateral Right Posterior Cerebral Lesions Sufficient to Cause Prosopagnosia? Clinical and Radiological Findings in Six Additional Patients

Cited by 210 publications

References 14 publications

Neural Activation during Covert Processing of Positive Emotional Facial Expressions

Neural Activation during Covert Processing of Positive Emotional Facial Expressions

Human neural systems for face recognition and social communication

Electrophysiological Studies of Face Perception in Humans

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