Are volunteers delivering semen samples in fertility studies a biased population?

Eustache, Florence; Auger, Jacques; Cabrol, D.; Jouannet, Pierre

doi:10.1093/humrep/deh503

Cited by 34 publications

(22 citation statements)

References 25 publications

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“…Because young men were recruited from a university, they may be under a lot of stress, which could potentially contribute to the lower semen quality observed in this cohort. However, several reports have demonstrated that higher educational level is positively associated with semen quality [37,38]. From our work, we believe that the factor contributing most to semen quality is ejaculation abstinence.…”

Section: Discussionsupporting

confidence: 51%

“…There were no associations in fertile Japanese men; in contrast, in young men from the general Japanese population, the gr/gr subdeletion was associated with reduced sperm motility (P ¼ 0.031, beta ¼ À5. 38). The combined analysis of the two cohorts also showed that the gr/gr subdeletion was associated with reduced sperm motility (P ¼ 0.0097, beta ¼ À5.74) ( Table 4).…”

Section: Association Analysis Of Y Chromosome Haplogroup and Semen Qumentioning

confidence: 78%

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Y Chromosome gr/gr Subdeletion Is Associated with Lower Semen Quality in Young Men from the General Japanese Population but Not in Fertile Japanese Men1

Sato

Iwamoto

Shinka

et al. 2014

Biology of Reproduction

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Several case-control studies have investigated whether Y chromosome haplogroups or deletions are associated with spermatogenic failure. However, the relationships between Y chromosome haplogroups or deletions and semen quality in general population have not been elucidated. In this study, we assessed relationships between Y chromosome haplogroups or deletions and semen parameters in 791 fertile Japanese men and 1221 young men from the general Japanese population. We found that the haplogroup D2 (M55 lineage) was significantly associated with lower semen parameters, especially total motile sperm count (P = 0.00051, beta = -0.097), in men from the general population but not in fertile men. In addition, we found that the gr/gr subdeletion was associated with semen quality and in particular, strongly associated with decreased sperm motility (P = 0.00041, beta = -3.14) and total motile sperm count (P = 0.00031, beta = -0.099) in men from the general population but not in fertile men. The combined analysis of fertile Japanese men and men from the general Japanese population showed that the haplogroup D2 (M55 lineage) and the gr/gr subdeletion were strongly associated with reduced sperm motility (P = 0.00056, beta = -2.71, and P = 7.7 × 10(-5), beta = -3.05, respectively) and that haplogroup O2b1 was strongly associated with elevated sperm motility (P = 0.00089, beta = 2.94). These observations add further support for the view that the gr/gr subdeletion diminishes sperm motility that consequently may result in male infertility.

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Section: Discussionsupporting

confidence: 51%

Section: Association Analysis Of Y Chromosome Haplogroup and Semen Qumentioning

confidence: 78%

Y Chromosome gr/gr Subdeletion Is Associated with Lower Semen Quality in Young Men from the General Japanese Population but Not in Fertile Japanese Men1

Sato

Iwamoto

Shinka

et al. 2014

Biology of Reproduction

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“…Eustache et al [13] evaluated selection bias in a study of reproductive health among three groups of male partners of pregnant women. They reported that those who agreed to give a semen sample were more likely than those who only filled out a questionnaire to have taken longer than twelve months to conceive (9.7% vs. 5.0%), and that the two groups who participated at any level were more likely than the general population to have a history of urogenital disease (8.8% versus 1-2%).…”

Section: Discussionmentioning

confidence: 99%

Assessment of selection bias in clinic‐based populations of childhood cancer survivors: A report from the childhood cancer survivor study

Ness

Leisenring

Goodman

et al. 2009

Pediatric Blood & Cancer

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Background It is not known to what extent prevalence estimates of late effects among childhood cancer survivors derived from clinic based samples represent the actual estimates that would be derived if the entire population of childhood cancer survivors was recruited and evaluated for a particular outcome. Procedure In a large retrospective cohort study of childhood cancer survivors, the Childhood Cancer Survivor Study (CCSS), the prevalence of chronic health conditions among participants who reported being seen in a cancer center or long-term follow-up clinic was compared to the prevalence of chronic conditions in the entire cohort. Results When compared to survivors who had no medical care in the previous two years, survivors accessing medical follow-up were significantly more likely to have chronic health conditions. Relative risks of reporting a chronic health condition were 1.4 (95% CI 1.3 – 1.5) if seen in a cancer center or long-term follow-up clinic and 1.2 (95% CI 1.1-1.3) if seen in a general medical care setting. Estimates derived from only those childhood cancer survivors who were seen in a cancer center or long term follow-up clinic overestimate the prevalence of any chronic disease by 9.3% (95% CI: 7.0-11.6%). Conclusions Applying chronic condition prevalence estimates from a clinical population to the general population of childhood cancer survivors must be undertaken with caution. Survivorship research must maintain a high level of scientific rigor to ensure that results reported in the literature are interpreted within the appropriate context.

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“…Men who have experienced an infertile period or medical problems that may impair fertility are more likely to participate in semen studies than other men. 27 To prevent such bias, we performed a full medical and andrological examination and we excluded all subjects with identified infertility risk factors.…”

Section: Discussionmentioning

confidence: 99%

Glycol ethers and semen quality: a cross-sectional study among male workers in the Paris Municipality

et al. 2007

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Are volunteers delivering semen samples in fertility studies a biased population?

Abstract: The present study does not suggest major selection bias, although the social and reproductive histories of these men may prompt them to participate. Such factors need to be accounted for in similar studies.

Cited by 34 publications

References 25 publications

Y Chromosome gr/gr Subdeletion Is Associated with Lower Semen Quality in Young Men from the General Japanese Population but Not in Fertile Japanese Men1

Y Chromosome gr/gr Subdeletion Is Associated with Lower Semen Quality in Young Men from the General Japanese Population but Not in Fertile Japanese Men1

Assessment of selection bias in clinic‐based populations of childhood cancer survivors: A report from the childhood cancer survivor study

Glycol ethers and semen quality: a cross-sectional study among male workers in the Paris Municipality

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