Abstract:Although evidence shows that women who correctly practice BSE monthly are more likely to detect a lump in the early stage, with early diagnosis and treatment yielding better survival, few women regularly perform BSE and many do not even know how to perform it. The aim of this study was to evaluate the effect of a health education intervention on "breast self-examination" regarding for knowledge, attitude, and practice among female students. Quasi-experimental study was carried out on 180 female student's sitting in the Faculty of Physical Education at Zagazig University and its affiliated hostel. The data collection tools included a self-administered questionnaire and an observation checklist to assess student's performance of BSE before and after the intervention. The results showed that these students have deficient knowledge and low perceptions regarding breast cancer and BSE; although the majority had positive attitudes, their practice of BSE is very deficient. The educational intervention was effective in improving students' knowledge, perceptions, attitudes, and practice. The intervention was a significant independent positive predictor of student's knowledge and practice scores, while the attitude score is modulated through the knowledge score. In conclusion, the university students at the Faculty of physical Education have deficient knowledge, low perceptions and inadequate practice regarding breast cancer and BSE. The educational intervention is effective in improving their knowledge, perceptions, attitudes, and practice. It is recommended that health education programs for university students, and the curriculum of the faculties of education should include some health-related issues. It is proposed to replicate this study using a randomized clinical trial design in order to confirm the findings and to provide a higher level of evidence.