“Are you sure it’s about ‘age’?”

Rusínová, Kateřina; Guidet, Bertrand

doi:10.1007/s00134-013-3147-x

Cited by 8 publications

(8 citation statements)

References 15 publications

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“…Moreover, the mechanisms underlying the aging process are heterogeneous. Therefore, clinicians need a method for quantifying the interindividual variability in aging rate [11].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study

et al. 2014

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Conflict of interest statement. PLM, AR, EC, MSM, OM, GLG, DS, CC, FF, YM, and PS declare that they have no conflicts of interest. SL has received consulting fees from Viforpharma. KA has received lecturing and consulting fees from Braun, Astellas, and Fresenius. AbstractPurpose: Frailty is a recent concept used for evaluating elderly individuals. Our study determined the prevalence of frailty in intensive care unit (ICU) patients and its impact on the rate of mortality. Methods:A multicenter, prospective, observational study performed in four ICUs in France included 196 patients aged ≥65 years hospitalized for >24 hours during a 6-month study period. Frailty was determined using the frailty phenotype (FP) and the clinical frailty score (CFS). The patients were separated as follows: FP score <3 or ≥3 and CFS < 5 or ≥ 5.Results: Frailty was observed in 41% and 23% of patients based on a FP score ≥3 and a CFS ≥5, respectively. At admission to the ICU, the Simplified Acute Physiology Score II (SAPS II) and Sequential Organ Failure Assessment (SOFA) scores did not differ between the frail and nonfrail patients. In the multivariate analysis, the risk factors for ICU mortality were FP score ≥3 (hazard ratio [HR], 3.3; 95% confidence interval [CI], 1.6-6.6; p<0.001), male gender (HR, 2.4; 95% CI, 1.1-5.3; p=0.026), cardiac arrest before admission (HR, 2.8; 95% CI, 1.1-7.4; p=0.036), SAPS II score ≥ 46 (HR, 2.6; 95% CI, 1.2-5.3; p=0.011), and brain injury before admission (HR, 3.5; 95% CI, 1.6-7.7; p=0.002). The risk factors for 6-month mortality were a CFS ≥5 (HR, 2.4; 95% CI, 1.49-3.87; p<0.001) and a SOFA score ≥7 (HR, 2.2; 95% CI, 1.35-3.64; p=0.002). An increased CFS was associated with significant incremental hospital and 6-month mortalities. Conclusions:Frailty is a frequent occurrence and is independently associated with increased ICU and 6-month mortalities.Notably, the CFS predicts outcomes more effectively than the commonly used ICU illness scores.

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“…Moreover, the mechanisms underlying the aging process are heterogeneous. Therefore, clinicians need a method for quantifying the interindividual variability in aging rate [11].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study

et al. 2014

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“…В литературе накоплено большое количество данных о том, что НСР в старшем возрасте достоверно ассоциированы с ухудшением гериатрического статуса [3,4]. Имеются данные, что у пациентов с НСР и проводимости самостоятельными факторами ухудшения гериатрического статуса яв ляются увеличение их возраста и наличие постоянных форм фибрилляции и трепетания предсердий.…”

Section: Introductionunclassified

“…2 , Кравченко Е. С. 2,3 , Покачалова М. А. 4 1 ФГАОУ ВО "Белгородский государственный национальный исследовательский университет".…”

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“…Белгород; 2 Академия постдипломного образования ФГБУ ФНКЦ ФМБА России. Москва; 3 Свердловский областной клинический психоневрологический госпиталь для ветеранов войн. Екатеринбург; 4 Частное учреждение здравоохранения "Клиническая больница "РЖД-Медицина".…”

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Progressive multifaceted approach to the management of geriatric patients with cardiac arrhythmias

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Коршун

et al. 2020

Cardiovasc Ther Prev

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Aim. To develop a progressive multifaceted approach to the management of geriatric patients with cardiac arrhythmias.Material and methods. The study was carried out in 2 stages. The study sample consisted of 262 elderly and senile people (mean age, 69,5±1,1 years). There 145 elderly (mean age, 68,4±1,2 years) and 117 senile patients (mean age 74,4±1,3 years). We analyzed medications used for six months in geriatric patients with arrhytmias and senile asthenia (SA) and without it. The combined strategy of management of geriatric patients with arrhytmias and SA was tested.Results. SA is most common in geriatric patients who are taking drugs such as class I a, b, c antiarrhythmics, class V antiarrhythmics (cardiac glycosides), diuretics (torasemide, furosemide), and statins. This indicates the need to avoid polypharmacy and to adjust the treatment of geriatric patients with cardiac arrhythmias in accordance with Beers criteria. Presented study revealed that in patients with SA, the total antioxidant activity is reduced, which indicates the need to restore antioxidant defence to such patients. A combined strategy has been developed for the management of geriatric patients with cardiac arrhytmias and SA.Conclusion. The combined strategy of managing older patients with arrhytmias and SA helped to improve the geriatric status, prevent SA, and increase antioxidant defence. A significant improvement in the quality of life was noted, in particular, in relation to the mental and psychological well-being.

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“…For years, there has been a steady increase in the percentage of people older than 60 years as compared to the total population. In the 1950s, they accounted for only 8% of the population, increasing to 10% in 2000, and estimated to reach 21% by 2050 ( 1 ). Over the next few decades, the population aged over 80 years will double.…”

Section: Introductionmentioning

confidence: 99%

Sepsis and Immunosenescence in the Elderly Patient: A Review

2017

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Sepsis is a prevalent, serious medical condition with substantial mortality and a significant consumption of health-care resources. Its incidence has increased around 9% annually in general population over the last years and specially in aged patients group. Several risk factors such as comorbidities, preadmission status, malnutrition, frailty, and an impared function in the immune system called immunosenescence are involved in the higher predisposition to sepsis in the elderly patients. Immunosenescence status consists in a functional impairment in both cell-mediated immunity and humoral immune responses and increases not only the risk for develop sepsis but also lead to more severe presentation of infection and may be is also related with a higher mortality. There is a also a concern about to admit patients in the intensive care units taking into account that the outcome of elderly patients is poorer compared to younger people. Nevertheless, the management of septic elderly patients does not differ substantially from younger people. In addition, the quality of life in septic elderly survivors is also lower than in younger people. But age, as alone factor, should not be used to determine treatment options because the poorer outcomes is thought to be due to the increased comorbidities and frailty in this group of patients.

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“Are you sure it’s about ‘age’?”

Cited by 8 publications

References 15 publications

Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study

Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study

Progressive multifaceted approach to the management of geriatric patients with cardiac arrhythmias

Sepsis and Immunosenescence in the Elderly Patient: A Review

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