Are γ-terpinene, 1,8-cineole, p-coumaric acid, and quercetin active against wild-type and non–wild-type Sporothrix brasiliensis to itraconazole?

Sporotrichosis, recognized by the World Health Organization (WHO) as a neglected tropical disease and classified among significant fungal health concerns, remains both underestimated and underreported. There is a profound impact of sporotrichosis on public health, affecting both humans and domestic animals. The causative agents are fungi within the Sporothrix genus, primarily transmitted through traumatic exposure to contaminated soil, plants, decomposing materials, or through scratches from infected animals, notably cats. While sporotrichosis is a global concern, its prevalence is particularly noteworthy in tropical and subtropical regions. The limited treatment options for sporotrichosis, with itraconazole as the preferred choice, underscore the challenges posed by fungal infections. Issues such as toxicity and drug resistance further complicate effective management. Consequently, this review aims to elucidate key objectives: identification of novel synthetic compounds revealed in the literature, highlighting ongoing efforts to develop new treatments against sporotrichosis, examining promising anti-sporothrix natural products, and providing an overview of endeavors to repurpose approved drugs. The key findings from the study underscore the urgent need for diversified and effective drugs for the treatment of Sporotrichosis.

show abstract

Antifungal activity of indolicidin-derived peptide In-58 against Sporothrix globosa in vitro and in vivo

Li,

Tang,

Liu

et al. 2024

Front. Med.

View full text Add to dashboard Cite

In-58, a peptide derived from indolicidin, shows extraordinary antibacterial activity and lower toxicity than indolicidin toward mammalian cells. Here, we investigated the antifungal activity of In-58 against the human pathogen Sporothrix globosa in vitro and in vivo. In-58 markedly inhibited the growth of Sporothrix globosa isolates in microdilution assays and showed no antagonism with any tested antifungal agent (itraconazole, terbinafine or amphotericin B). Scanning electron microscopy and propidium iodide staining indicated that In-58 alters the cell wall integrity and interacts with DNA, leading to disruption of S. globosa in a dose-dependent manner. In S. globosa, the mitochondrial membrane potential decreased and reactive oxygen species increased after treatment with In-58. In vivo experiments in the Galleria mellonella (greater wax moth) larval infection model revealed the effectiveness of In-58 against S. globosa infection with low toxicity. Our results indicate that In-58 possesses remarkable antifungal activity against S. globosa in vitro and in vivo. It has potential as a novel drug for the treatment of sporotrichosis.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Are γ-terpinene, 1,8-cineole, p-coumaric acid, and quercetin active against wild-type and non–wild-type Sporothrix brasiliensis to itraconazole?

Cited by 3 publications

References 32 publications

Screening of alkaloids and withanolides isolated from Solanaceae plants for antifungal properties against non-wild type Sporothrix brasiliensis

Screening of alkaloids and withanolides isolated from Solanaceae plants for antifungal properties against non-wild type Sporothrix brasiliensis

Innovations in Treating Sporotrichosis: Drug Repurposing and Lead Compound Synthesis

Antifungal activity of indolicidin-derived peptide In-58 against Sporothrix globosa in vitro and in vivo

Contact Info

Product

Resources

About