Areas of Capsaicin-Induced Secondary Hyperalgesia and Allodynia Are Reduced by a Single Chiropractic Adjustment: A Preliminary Study

Mohammadian, Parvaneh; Gonsalves, Antonio; Tsai, Chris; Hummel, Thomas; Carpenter, Thomas M.

doi:10.1016/j.jmpt.2004.05.002

Cited by 29 publications

(22 citation statements)

References 19 publications

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“…The region targeted for SMT included the cervical spine (11 studies) [Fernandez-Carnero et al, 2008; Fernandez-de-Las-Penas et al, 2008; Fernandez-de-las-Penas et al, 2007; Hamilton et al, 2007; Maduro de Camargo et al, 2011; Mansilla-Ferragut et al, 2009; Oliveira-Campelo et al, 2010; Parkin-Smith et al, 1998; Rubinstein et al, 2011; van Schalkwyk et al, 2000; Vernon et al, 1990], thoracic spine (5 studies) [Bishop et al, 2011; Fryer et al, 2004; Mohammadian et al, 2004; Parkin-Smith et al, 1998; Terrett et al, 1984], and lumbosacral spine (5 studies) [Bialosky et al, 2009b; Cote et al, 1994; George et al, 2006; Shearar et al, 2005; Thomson et al, 2009]. One study examined both cervical and thoracic manipulation [Parkin-Smith et al, 1998].…”

Section: Resultsmentioning

confidence: 99%

Changes in pain sensitivity following spinal manipulation: A systematic review and meta-analysis

Coronado¹,

Gay²,

Bialosky³

et al. 2012

Journal of Electromyography and Kinesiology

170

138

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Spinal manipulation (SMT) is commonly used for treating individuals experiencing musculoskeletal pain. The mechanisms of SMT remain unclear; however, pain sensitivity testing may provide insight into these mechanisms. The purpose of this systematic review is to examine the literature on the hypoalgesic effects of SMT on pain sensitivity measures and to quantify these effects using meta-analysis. We performed a systematic search of articles using CINAHL, MEDLINE, PsycINFO, and SPORTDiscus from each databases’ inception until May 2011. We examined methodological quality of each study and generated pooled effect size estimates using meta-analysis software. Of 997 articles identified, 20 met inclusion criteria for this review. Pain sensitivity testing used in these studies included chemical, electrical, mechanical, and thermal stimuli applied to various anatomical locations. Meta-analysis was appropriate for studies examining the immediate effect of SMT on mechanical pressure pain threshold (PPT). SMT demonstrated a favorable effect over other interventions on increasing PPT. Subgroup analysis showed a significant effect of SMT on increasing PPT at the remote sites of stimulus application supporting a potential central nervous system mechanism. Future studies of SMT related hypoalgesia should include multiple experimental stimuli and test at multiple anatomical sites.

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Section: Resultsmentioning

confidence: 99%

Changes in pain sensitivity following spinal manipulation: A systematic review and meta-analysis

Coronado¹,

Gay²,

Bialosky³

et al. 2012

Journal of Electromyography and Kinesiology

170

138

View full text Add to dashboard Cite

show abstract

“…Four studies ( [29,35,36,40]) applied the SMT to a point on the spine thought to be in need of treatment, i.e. at what was considered to be a dysfunctional spinal segment (manipulable lesion/fixation/subluxation), whereas in all other studies the exact location of SMT was predetermined without reference to local signs or symptoms.…”

Section: Resultsmentioning

confidence: 99%

The effect of spinal manipulative therapy on experimentally induced pain: a systematic literature review

et al. 2012

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BackgroundAlthough there is evidence that spinal manipulative therapy (SMT) can reduce pain, the mechanisms involved are not well established. There is a need to review the scientific literature to establish the evidence-base for the reduction of pain following SMT.ObjectivesTo determine if SMT can reduce experimentally induced pain, and if so, if the effect is i) only at the level of the treated spinal segment, ii) broader but in the same general region as SMT is performed, or iii) systemic.DesignA systematic critical literature review.MethodsA systematic search was performed for experimental studies on healthy volunteers and people without chronic syndromes, in which the immediate effect of SMT was tested. Articles selected were reviewed blindly by two authors. A summary quality score was calculated to indicate level of manuscript quality. Outcome was considered positive if the pain-reducing effect was statistically significant. Separate evidence tables were constructed with information relevant to each research question. Results were interpreted taking into account their manuscript quality.ResultsTwenty-two articles were included, describing 43 experiments, primarily on pain produced by pressure (n = 27) or temperature (n = 9). Their quality was generally moderate. A hypoalgesic effect was shown in 19/27 experiments on pressure pain, produced by pressure in 3/9 on pain produced by temperature and in 6/7 tests on pain induced by other measures. Second pain provoked by temperature seems to respond to SMT but not first pain. Most studies revealed a local or regional hypoalgesic effect whereas a systematic effect was unclear. Manipulation of a “restricted motion segment” (“manipulable lesion”) seemed not to be essential to analgesia. In relation to outcome, there was no discernible difference between studies with higher vs. lower quality scores.ConclusionsThese results indicate that SMT has a direct local/regional hypoalgesic effect on experimental pain for some types of stimuli. Further research is needed to determine i) if there is also a systemic effect, ii) the exact mechanisms by which SMT attenuates pain, and iii) whether this response is clinically significant.

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“…The model uses associated neuromuscular responses following MT to provide indirect evidence for a spinal cord mediated mechanism. For example, MT is associated with hypoalgesia (George et al, 2006;Mohammadian et al, 2004;Vicenzino et al, 2001), afferent discharge (Colloca et al, 2000;Colloca et al, 2003), motoneuron pool activity (Bulbulian et al, 2002;Dishman & Burke, 2003), and changes in muscle activity (Herzog et al, 1999;Symons et al, 2000) all of which may indirectly implicate a spinal cord mediated effect.…”

Section: Proposed Modelmentioning

confidence: 99%

“…The model is intended to highlight differing possibilities when conclusions are drawn which may be further explored in subsequent studies. For example, studies have reported hypoalgesia following MT (George et al, 2006;Mohammadian et al, 2004). (George et al, 2006) suggested a spinal cord mediated mechanism due to associated hypoalgesia of temporal summation.…”

Section: Implementation Of Comprehensive Modelmentioning

confidence: 99%

The mechanisms of manual therapy in the treatment of musculoskeletal pain: A comprehensive model

et al. 2009

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Prior studies suggest manual therapy (MT) as effective in the treatment of musculoskeletal pain; however, the mechanisms through which MT exerts its effects are not established. In this paper we present a comprehensive model to direct future studies in MT. This model provides visualization of potential individual mechanisms of MT that the current literature suggests as pertinent and provides a framework for the consideration of the potential interaction between these individual mechanisms. Specifically, this model suggests that a mechanical force from MT initiates a cascade of neurophysiological responses from the peripheral and central nervous system which are then responsible for the clinical outcomes. This model provides clear direction so that future studies may provide appropriate methodology to account for multiple potential pertinent mechanisms.

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Areas of Capsaicin-Induced Secondary Hyperalgesia and Allodynia Are Reduced by a Single Chiropractic Adjustment: A Preliminary Study

Cited by 29 publications

References 19 publications

Changes in pain sensitivity following spinal manipulation: A systematic review and meta-analysis

Changes in pain sensitivity following spinal manipulation: A systematic review and meta-analysis

The effect of spinal manipulative therapy on experimentally induced pain: a systematic literature review

The mechanisms of manual therapy in the treatment of musculoskeletal pain: A comprehensive model

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