Arginine for gestating sows and foetal development: A systematic review

Palencia, Jorge Y P; Lemes, Marina Alves Gomes; Garbossa, César Augusto Pospissil; Abreu, Márvio Lobão Teixeira de; Pereira, Luciano José; Zangerônimo, Márcio Gilberto

doi:10.1111/jpn.12679

Cited by 24 publications

(21 citation statements)

References 40 publications

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“…The general information about the articles selected for each database is presented in Tables 1 and 2 As part of the methodology of the systematic review, quality criteria that allowed the characterization of articles for precision in the methodology were employed (Table 3), assuring the reliability of the results (Palencia et al, 2017). The final objective of this evaluation was to note and discuss some relevant aspects of experimentation to improve methods and protocols used in the development of research projects.…”

Section: Systematic Reviewmentioning

confidence: 99%

Variability of piglet birth weights: A systematic review and meta‐analysis

Moreira

Palencia

Moita

et al. 2019

Animal Physiology Nutrition

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The objective of the study was to evaluate the effects of litter size and supplementation of functional amino acids on the piglet birth weight variability through of a systematic review and meta‐analysis. PubMed, ISI Web of Science, Science Direct, Scopus and SciELO are the main used databases and were searched in January 2019 by using the following keywords and their combinations: within‐litter birth, weight variability, piglets, litter size, sow, amino acids, gestation, uniformity, CV and/or SD. Of the 64 pre‐selected articles, only articles presenting the coefficients of variation and/or standard deviations according to the litter size and different levels of amino acid supplementation in the sow diets during gestation were selected. The average birth weights of total and live piglets were 43% lower in litters from sows with high prolificacy than those from sows with low prolificacy. The weight variability was affected by high prolificacy sows, with increases of 4.04% and 4.54% in the coefficients of variation of total and born alive piglets respectively (p = .074; p = .009). The standard deviation increased by 180 g in born alive piglets to high prolificacy sows. The coefficients of variation of total and live piglets born from high prolificacy sows showed an increase of 4.04% and 4.54% respectively (p = .07; p < .05). There was a tendency for reduced weight variability with amino acids supplementation when considering the standard deviation of total born (p = .072). However, reproductive performance was not significantly influenced (p > .05). In conclusion, the average litter weight and the number of piglets born influence weight variability. Amino acids supplementation may reduce the birth weight variability between piglets. However, this effect depends on the amino acid used, the levels of supplementation and on other factors not completely addressed in this study. Thus, more research is necessary to fully elucidate this topic.

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Section: Systematic Reviewmentioning

confidence: 99%

Variability of piglet birth weights: A systematic review and meta‐analysis

Moreira

Palencia

Moita

et al. 2019

Animal Physiology Nutrition

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“…The decreased values for within‐litter standard deviation and within‐litter coefficient of variation of piglet birthweights highlight the potential of L‐arginine supplementation to improve litter uniformity and lower the incidence of piglets with low viability (Madsen, Pardo, Kreuzer, & Bee, ; Palencia et al, ; Shi et al, ). Quesnel et al () observed a decreased coefficient of variation and improved uniformity in piglet birthweights after L‐arginine supplementation during the final third of gestation.…”

Section: Discussionmentioning

confidence: 99%

“…Piglet birthweight is thought to be directly related to piglet survival (Quiniou et al, 2002;Roehe & Kalm, 2000). The effect of L-arginine supplementation on piglet birthweight remains unclear, and the literature presents conflicting results (Palencia et al, 2017). L-arginine supplementation at 0.5% in the last third of gestation increased piglet birthweights by approximately 100 g, thus suggesting increased placental blood flow and improved foetal development compared with non-supplemented sows (Nuntapaitoon, Muns, Theil, & Tummaruk, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…When supplemented in other phases, L-arginine, as a precursor of polyamines and nitric oxide, positively affects vascular growth and blood flow in the final third of gestation(Reynolds et al, 2006;). The decreased values for within-litter standard deviation and within-litter coefficient of variation of piglet birthweights highlight the potential of L-arginine supplementation to improve litter uniformity and lower the incidence of piglets with low viability(Madsen, Pardo, Kreuzer, & Bee, 2017;Palencia et al, 2017;Shi et al, 2018) Quesnel et al (2014). observed a decreased coefficient of variation and improved uniformity in piglet birthweights after L-arginine supplementation during the final third of gestation Dallanora et al (2017).…”

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L‐arginine supplementation during the final third of gestation improves litter uniformity and physical characteristics of neonatal piglet thermoregulation

Moreira

Mendes

Palencia

et al. 2020

Animal Physiology Nutrition

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The study assessed the effects of dietary L‐arginine supplementation from days 85 to 115 of gestation on sow performance, litter quality, piglet physiology and survival variables in the first 24 hr of life. Twenty multiparous sows, with a history of hyperprolificacy (more than 14 piglets per litter), were used. A completely randomized experimental design was used, consisting of two treatments: feed supplemented or not with 1% L‐arginine from days 85 to 115 of gestation. The experimental unit consisted of the sow and its respective litter, using 10 replicates per treatment. The sows were distributed into the treatments based on body condition and parity. Supplementation with L‐arginine reduced the within‐litter standard deviation and the within‐litter coefficient of variation of piglet weight at 24 hr by 54 g and 4.14 percentage points respectively (p = .029; p = .035). Supplementation with 1.0% L‐arginine decreased the percentages of piglets weighing less than 800 g by 5.60 and 5.08 points at birth and at 24 hr of life respectively. Piglets from sows supplemented with L‐arginine had higher (p = .088) average rectal temperatures at birth and lower (p = .030) rectal temperature at 24 hr of life in comparison with control piglets. No significant differences in placental weight or estimated colostrum production and intake were observed in the first 24 hr of life. At 24 hr of life, piglets weighing less than 1,000 g and from supplemented sows had lower (p = .048) surface/mass ratios and higher body mass index (p = .070). Piglets from supplemented sows and who weighed 1601 to 1,800 g had lower body mass index and ponderal index (p = .002; p = .003). Supplementation with L‐arginine during the final third of gestation reduces the incidence of unviable piglets (<800 g) and improved litter uniformity and piglets’ body conformation within the first 24 hr of life.

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“…Although a study by Li et al. () detected reduced embryonic survival and plasma progesterone in sows during gestation at diets containing a total of 1.5% arginine in the diet (0.8% of which was supplemented), other authors reported beneficial effects on embryonic/foetal survival in sows and survival of offspring with diets containing up to a total of 1.7% arginine in the diet (up to 1% of which was supplemented) (Mateo et al., , ; Li et al., ; Palencia et al., ). The FEEDAP Panel notes that this literature review, while providing some additional information, does not modify the previous assessments concerning arginine supplementation in target species (EFSA, ; EFSA FEEDAP Panel, , ).…”

Section: Assessmentmentioning

confidence: 99%

Safety and efficacy of l‐arginine produced by fermentation with Escherichia coli NITE BP‐02186 for all animal species

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et al. 2018

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L-Arginine is considered as a non-essential amino acid for most adult mammalian species, but it is classified as essential for birds, fish, possibly reptiles and also for strict carnivores. L-Arginine produced by fermentation with Escherichia coli NITE BP-02186, genetically modified to enhance the production of L-arginine, is intended to be used in feed and water for drinking for all animal species and categories. The product under assessment does not give rise to any safety concern with regard to the genetic modification of the production strain. Its use as a nutritional additive is safe for target species when supplemented to diets in appropriate amounts. The use of L-arginine as a feed flavouring agent is unlikely to pose any concern. No risks are expected for the consumer from the use of the product under assessment as a feed additive. It is not irritant to skin or eyes, nor a skin sensitiser. Although the presence of endotoxin activity is of no concern, the available exposure and toxicological data indicate that the additive may pose a risk to users by inhalation. The use of this additive in animal nutrition does not pose a risk to the environment. The additive is an effective source of arginine for all species. L-Arginine is considered efficacious when used as a flavouring compound in animal nutrition. es-Call J and Wallace RJ, 2018. Scientific Opinion on the safety and efficacy of L-arginine produced by fermentation with Escherichia coli NITE BP-02186 for all animal species. EFSA Journal 2018;16(5):5276, 21 pp. https://doi.

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Arginine for gestating sows and foetal development: A systematic review

Cited by 24 publications

References 40 publications

Variability of piglet birth weights: A systematic review and meta‐analysis

Variability of piglet birth weights: A systematic review and meta‐analysis

L‐arginine supplementation during the final third of gestation improves litter uniformity and physical characteristics of neonatal piglet thermoregulation

Safety and efficacy of l‐arginine produced by fermentation with Escherichia coli NITE BP‐02186 for all animal species

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