Arginine Therapy for Lung Diseases

Scott, Jeremy A.; Maarsingh, Harm; Holguín, Fernando; Grasemann, Hartmut

doi:10.3389/fphar.2021.627503

Cited by 43 publications

(28 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an animal model, arginase inhibition shifted the ornithine-citrulline ratio toward citrulline and prevented neutrophilia, mucus hypersecretion, airway fibrosis, and pulmonary hypertension. Increasing the availability of substrate for NOS by arginase inhibition or supplementation with L-arginine, L-citrulline or a combination thereof can also be applied to human COPD [71].…”

Section: Citrulline-arginine and Arginine-ornithine Pathwaysmentioning

confidence: 99%

Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease

et al. 2021

View full text Add to dashboard Cite

The respiratory system is continuously exposed to endogenous and exogenous oxidants. Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, leading to the destruction of lung parenchyma (emphysema) and declining pulmonary function. It is increasingly obvious that reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to the progression and amplification of the inflammatory responses related to this disease. First, we described the association between cigarette smoking, the most representative exogenous oxidant, and COPD and then presented the multiple pathophysiological aspects of ROS and antioxidative defense systems in the development and progression of COPD. Second, the relationship between nitric oxide system (endothelial) dysfunction and oxidative stress has been discussed. Third, we have provided data on the use of these biomarkers in the pathogenetic mechanisms involved in COPD and its progression and presented an overview of oxidative stress biomarkers having clinical applications in respiratory medicine, including those in exhaled breath, as per recent observations. Finally, we explained the findings of recent clinical and experimental studies evaluating the efficacy of antioxidative interventions for COPD. Future breakthroughs in antioxidative therapy may provide a promising therapeutic strategy for the prevention and treatment of COPD.

show abstract

Section: Citrulline-arginine and Arginine-ornithine Pathwaysmentioning

confidence: 99%

Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Supplemental citrulline may aid NO synthesis, which work in various ways to oppose pathogenic mechanisms in asthma [18]. Observational studies also noted that the biosynthesis of endogenous L-arginine from L-citrulline is disturbed in asthma patients [19]. Although there is emerging evidence about the protective functions of L-citrulline during asthma, few clinical studies have evaluated the comprehensive metabolic profile and associated pathways in young chronic persistent asthma adults.…”

Section: Discussionmentioning

confidence: 99%

“…The particularly significant role of L-arginine in bronchial asthma lies in its involvement in biosynthesis of polyamines and NO [20], which is produced by a family of isoenzymes and all utilize L-arginine as substrate [19]. Thus, decreased level of L-citrulline and L-arginine may lead to airway hyper responsiveness, inflammation, and airway remodeling in the development of asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, L-arginine supplementation inhibits oxidative stress in HBECs [25]. Various therapeutic strategies to increase L-arginine levels or bioavailability, including supplementation of L-arginine or L-citrulline and inhibition of arginase, are currently being explored [19]. However, evidence application of L-arginine supplemental therapy is limited, as L-arginine metabolism firstly occurred in the liver and intestine.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells

et al. 2021

View full text Add to dashboard Cite

Background: Recent metabolomics studies have found circulatory metabolism alterations in patients with asthma, indicating that altered metabolites played a significant role in asthma. However, the regulatory mechanisms in asthma, especially in young chronic persistent asthma remain underexplored. Methods: In this study, a prospective cohort of 162 patients diagnosed of asthma admitted to the First Affiliated Hospital of Xi’an Jiaotong University from January 2018 to December 2019 was used to perform a nested case-control study. Among them, we included 30 patients with chronic persistent asthma between 20 to 35 years old; 30 health control with evenly distributed age and sex were then recruited. Nontargeted metabolomics was applied to identify serum metabolic profiles and altered metabolic pathways. Results: In vitro, human bronchial epithelial cells (HBECs) line BEAS-2B with the addition of L-citrulline and/or asymmetric dimethylarginine (ADMA) model was utilized and the concentrations of nitric oxide (NO) metabolites were tested to evaluate the therapeutic potential of L-citrulline. The young patients with chronic persistent asthma displayed dysregulated serum metabolic profiles, especially enriched in arginine metabolism. The ratio of L-citrulline to ornithine is associated with blood eosinophil count. In vitro, adding L-citrulline could reverse ADMA-mediated reduction of NOx at lower L-arginine concentration (25 μM), but was ineffective in the higher L-arginine concentration (100 μM) media. Conclusions: The arginine metabolism balance is of vital importance during the pathogenesis and progression of chronic asthma. L-citrulline could be a powerful approach to restore airway NO production, potentially exhibiting therapeutic benefits among young patients with chronic asthma.

show abstract

“…Previous studies provided clues that L-citrulline metabolism contributed to pathogenesis of asthma in children [16]. Observational studies also noted that the biosynthesis of endogenous L-arginine from Lcitrulline is disturbed in asthma patients [17]. Although there is emerging evidence about the protective functions of L-citrulline during asthma, few clinical studies have evaluated the comprehensive metabolic pro le and associated pathways in young chronic persistent asthma adults.…”

Section: Discussionmentioning

confidence: 99%

Dysregulated Arginine Metabolism in Young Patients With Chronic Persistent Asthma and in Human Bronchial Epithelial Cells

Zhou

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Recent metabolomics studies have found circulatory metabolism alterations in patients with asthma, indicating that altered metabolites played a significant role in asthma. However, the regulatory mechanisms in asthma, especially in young chronic persistent asthma remain underexplored.Methods: In this study, a prospective cohort of 162 patients diagnosed of asthma admitted to the First Affiliated Hospital of Xi’an Jiaotong University from January 2018 to December 2019 was used to perform a nested case-control study. Among them, we included 30 patients with chronic persistent asthma between 20 to 35 years old; 30 health control with evenly distributed age and sex were then selected. Nontargeted metabolomics was applied to identify serum metabolic profiles and altered metabolic pathways. Results: In vitro, human bronchial epithelial cells (HBECs) line BEAS-2B with the addition of L-citrulline and/or asymmetric dimethylarginine (ADMA) model was utilized and the concentrations of nitric oxide (NO) metabolites were tested to evaluated the therapeutic potential of L-citrulline. The young patients with chronic persistent asthma displayed dysregulated serum metabolic profiles, especially enriched in arginine metabolism. The ratio of L-citrulline to ornithine is associated with blood eosinophil count. In vitro, adding L-citrulline could reverse ADMA-mediated reduction of NOx at lower L-arginine concentration (25 μM), but was ineffective in the higher L-arginine concentration (100 μM) media. Conclusions: The arginine metabolism balance is of vital importance during the pathogenesis and progression of chronic asthma. L-citrulline could be a powerful approach to restore airway NO production, potentially exhibiting therapeutic benefits among young patients with chronic asthma.

show abstract

Arginine Therapy for Lung Diseases

Cited by 43 publications

References 94 publications

Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease

Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease

Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells

Dysregulated Arginine Metabolism in Young Patients With Chronic Persistent Asthma and in Human Bronchial Epithelial Cells

Contact Info

Product

Resources

About