Arginine vasopressin 4–9 retards spatial alternation learning

McDaniel, William F.; Waters, Patti; Davall, E.J.

doi:10.1016/0143-4179(89)90049-8

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Previously only a few studies have found any effects of AVP on spatial memory. Intraseptal and subcutaneous AVP administration retarded acquisition of spatial learning and memory in the Morris water maze and T-maze tasks (McDaniel et al, 1989;Engelmann et al, 1992). In the present study, both genotypes demonstrated normal and statistically similar acquisition, retention, and retrieval of spatial memory.…”

Section: Discussionsupporting

confidence: 57%

Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Bielsky

Szegda

et al. 2003

Neuropsychopharmacol

476

338

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Considerable evidence suggests that arginine vasopressin (AVP) is critically involved in the regulation of many social and nonsocial behaviors, including emotionality. The existence of two AVP receptors in the brain, namely the V1a and V1b subtypes, and the lack of clear pharmacological data using selective agonists or antagonists, make it difficult to determine which receptor is responsible for the AVP-mediated effects on behavior. Here we report the behavioral effects of a null mutation in the V1a receptor (V1aR) in male mice. Male mice lacking functional V1aR (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and nonsocial olfactory learning and memory tasks. Acute central administration of AVP robustly stimulated stereotypical scratching and autogrooming in wild-type (WT), but not V1aRKO males. AVP and oxytocin (OT) mRNA and OT receptor-binding levels were similar in WT and V1aRKO mice. Given the current findings, the V1aR may provide a novel potential pharmacological target for social and affective disorders including autism, and anxiety disorders.

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Section: Discussionsupporting

confidence: 57%

Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Bielsky

Szegda

et al. 2003

Neuropsychopharmacol

476

338

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Vasopressin metabolites: A link between vasopressin and memory?

Reijmers

Ree

Spraijt

et al. 1999

Progress in Brain Research

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Inhibition by [Arg8]-Vasopressin of Long Term Potentiation in Guinea Pig Hippocampal Slice

Sakurai¹,

Maeda²,

Kaneko

et al. 1998

Japanese Journal of Pharmacology

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We examined the effects of [Arg8]-vasopressin (AVP) on long term potentiation (LTP) of the field excitatory postsynaptic potentials at CA1 and CA3 synapses in adult guinea pig hippocampal slices. AVP (10 nM) depressed the magnitude of LTP without any effects on basal responses at both synaptic pathways. The depressive effect by AVP at CA1 synapses appears to be receptor-mediated since it was inhibited by an AVP V1-receptor antagonist, [Pmp1,Tyr(Me)2]-AVP. From these results, AVP may play an inhibitory role on the induction of LTP via V1 receptors in the guinea pig hippocampus.

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Arginine vasopressin 4–9 retards spatial alternation learning

Cited by 3 publications

References 21 publications

Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Vasopressin metabolites: A link between vasopressin and memory?

Inhibition by [Arg8]-Vasopressin of Long Term Potentiation in Guinea Pig Hippocampal Slice

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