Arginine vasopressin V1a receptor antagonist impairs maternal memory in rats

Nephew, Benjamin C.; Bridges, Robert S.

doi:10.1016/j.physbeh.2008.05.016

Cited by 54 publications

(49 citation statements)

References 39 publications

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“…This suggests that the female's long-term social memory is impaired. As noted in the maternal behavior section, a V1a antagonist around parturition impairs the ability of a dam to re-initiate maternal care [68]. In general, the available data on AVP and female memory supports the literature from males concluding that AVP mediates various forms of memory consolidation and retention and has particular relevance to social memory.…”

Section: Avp and Female Animal Learning And Memorysupporting

confidence: 62%

“…It has also been postulated that the effects of OXT in pair bonding involve a social recognition function [67]. Similar to studies of the roles of dopamine and AVP in rodent maternal memory (the ability of a dam to quickly return to maternal care following a separation from her pups) [68,69], central OXT is involved in the consolidation of maternal memory [70]. One hypothesis is that the effects of both OXT and AVP are mediated by their actions on dopamine.…”

Section: Oxt and Female Animal Learning And Memorymentioning

confidence: 93%

“…Studies focusing specifically on maternal care conclude that central AVP promotes ongoing maternal care [48]. Furthermore, the blockade of V1a receptors around parturition impairs maternal memory, the ability of a maternal dam to return to maternal care following a prolonged separation from her pups [68]. Although it has been postulated that maternal nurturing is linked to innate anxiety and OXT and AVP activity, this is based mostly on studies of rodent lines selected for anxiety [175].…”

Section: Avp and Animal Maternal Behaviormentioning

confidence: 99%

See 2 more Smart Citations

Behavioral Roles of Oxytocin and Vasopressin

Nephew¹

2012

Neuroendocrinology and Behavior

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Section: Avp and Female Animal Learning And Memorysupporting

confidence: 62%

Section: Oxt and Female Animal Learning And Memorymentioning

confidence: 93%

Section: Avp and Animal Maternal Behaviormentioning

confidence: 99%

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Behavioral Roles of Oxytocin and Vasopressin

Nephew¹

2012

Neuroendocrinology and Behavior

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“…In connection with its role in circadian regulation [15] AVP might be such a molecule. Indeed, administration of AVP receptor antagonists resulted in memory impairment both in mice [3] and in rats [39]. The adult AVP-deficient Brattleboro rats showed reduced social discrimination ability which was improved by AVP administration [16].…”

Section: Introductionmentioning

confidence: 99%

Increase in Alzheimer's related markers preceeds memory disturbances: Studies in vasopressin-deficient Brattleboro rat

Várga

Klausz

Domokos

et al. 2014

Brain Research Bulletin

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Alzheimer's disease (AD) is the most common form of dementia in the elderly. For more effective therapy early diagnostic markers could be beneficial. Therefore we compared one year old rats with adults and examined if changes in possible brain markers of AD preceeded memory decline. We also tested if vasopressin-deficient animals were useful model of AD as vasopressin has well known positive effect on memory and AD patient has decreased vasopressin production.We compared adult (3 month) and old (12 month), normal and vasopressin-deficient Brattleboro rats. To receive a comprehensive picture about their memory we examined their social discrimination, object discrimination and conditioned learning abilities (shuttle box).Amyloid precursor protein (APP), mitogen-activated protein kinase 1 (MAPK1), β-actin and tryptophan 2,3-dioxygenase 2 (TDO2) mRNA levels was measured by quantitative PCR.There was no difference between the memory of adult and aged groups. The vasopressin-deficient rats at both ages showed a weaker performance in the course of social and object discrimination tests and a higher escape failure during the shuttle box experiment. The brain marker mRNAs of the elder animals were higher than the levels of the adults, but the absence of vasopressin had no influence on them.Thus, the one year old rats showed elevated levels of AD-related markers, but memory deficits were observable only in vasopressin deficient animals. Vasopressin does not seem to have pathogenic role in AD. Changes in the studied markers might predict later symptoms, although further studies are required for confirmation.

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“…However, there is substantial evidence for significant activation of the brain AVP system around parturition and in lactation (16)(17)(18)(19)(20), which has mainly been discussed, to date, in the context of osmotic homeostasis maintenance (1,16,18). Interestingly, central infusion of AVP (21) or of an AVP receptor antagonist (AVP-A) altered the onset of maternal behavior (22), interpreted to be due to actions on oxytocin (OXT) receptors (OXT-Rs) (22), and affected maternal memor y (23), respectively.…”

mentioning

confidence: 99%

Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety

Bosch

Neumann²

2008

Proc. Natl. Acad. Sci. U.S.A.

241

264

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The neuropeptide arginine vasopressin (AVP) is arguably among the most potent regulators of social behaviors in mammals identified to date. However, only the related neuropeptide oxytocin (OXT) has been shown to promote maternal behavior. Here, we assess the role of AVP in maternal care, in particular in arched back nursing, pup retrieval, and pup contact by using complementary pharmacological and genetic approaches. Also, experiments were performed in rat dams with differences in trait anxiety, i.e., rats bred for either high (HAB) or low (LAB) anxiety-related behavior as well as nonselected (NAB) dams. Viral vector-mediated up-regulation of AVP V1a receptors (AVP-Rs) within the medial preoptic area of lactating NAB rats and chronic central AVP treatment of NAB and LAB dams improved, whereas local blockade of AVP-R expression by means of antisense oligodeoxynucleotides or central AVP-R antagonism impaired, maternal care in NAB dams. Also, in HAB rats with a genetically determined elevated brain AVP activity, intrinsically high levels of maternal care were reversed by blockade of AVP-R actions. Treatment-induced impairment of AVP-mediated maternal behavior increased adult emotionality and impaired social interactions in male offspring of NAB dams. These findings provide direct evidence for an essential and highly potent role of brain AVP in promoting maternal behavior, which seems to be independent of the dam's trait anxiety. adenoviral vector ͉ arched back nursing ͉ medial preoptic area ͉ antisense oligodeoxynucleotide ͉ pup retrieval T he neuropeptide arginine vasopressin (AVP) is a key player in the regulation of complex social behaviors in mammals (1). Investigations have mainly focused on males and shown that AVP-dependent social behaviors include social recognition and interaction (2-5), intermale aggression (6, 7), pair-bonding (8-10), and paternal care in monogamous biparental rodents (11,12). In addition, the related ancestral neuropeptide vasotocin, which is found in nonmammalian vertebrates, influences a wide range of reproductive behaviors in fish (13) and other vertebrates (14). So far, any direct involvement of AVP in regulating maternal behavior, one of the most important prosocial behaviors found in mammals, is largely unknown (1, 15). However, there is substantial evidence for significant activation of the brain AVP system around parturition and in lactation (16)(17)(18)(19)(20), which has mainly been discussed, to date, in the context of osmotic homeostasis maintenance (1,16,18). Interestingly, central infusion of AVP (21) or of an AVP receptor antagonist (AVP-A) altered the onset of maternal behavior (22), interpreted to be due to actions on oxytocin (OXT) receptors (OXT-Rs) (22), and affected maternal memor y (23), respectively.In the present experiments, we aimed to reveal AVP effects on maternal behavior mediated by the AVP V1a receptor (AVP-R). Therefore, we repeatedly treated lactating rat dams with either a selective AVP-A or OXT-R antagonist (OXT-A), or chronically infused either synthe...

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Arginine vasopressin V1a receptor antagonist impairs maternal memory in rats

Cited by 54 publications

References 39 publications

Behavioral Roles of Oxytocin and Vasopressin

Behavioral Roles of Oxytocin and Vasopressin

Increase in Alzheimer's related markers preceeds memory disturbances: Studies in vasopressin-deficient Brattleboro rat

Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety

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