Argon laser vs. subthreshold infrared (810-nm) diode laser macular grid photocoagulation in nonexudative age-related macular degeneration

Scorolli, L.; Corazza, Daniele; Morara, Mariachiara; Vismara, Sabrina; Lugaresi, Marialuisa; Meduri, R.

doi:10.1016/s0008-4182(03)80028-5

Cited by 20 publications

(10 citation statements)

References 10 publications

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“…Thus far, several clinical trials have indicated that laser treatment of the RPE cell layer has a benefi cial effect in patients with various macular pathologies [36][37][38][39] . Just recently, we were able to demonstrate that endoscopically guided subretinal laser treatment of the retinal pigment epithelium may stabilize or improve vision in patients with choroidal neovascularization secondary to age-related macular degeneration [40] .…”

Section: Discussionmentioning

confidence: 99%

Pigment-Epithelium-Derived Factor Is Upregulated in Photocoagulated Human Retinal Pigment Epithelial Cells

et al. 2005

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There is much evidence that pigment-epithelium-derived factor (PEDF) is a potent antiangiogenic cytokine which inhibits retinal and choroidal neovascularization by inducing apoptosis in activated vascular endothelial cells. Furthermore, the regulation of PEDF appears to be linked to the regulation of vascular endothelial growth factor (VEGF), one of the most potent inducers of intraocular neovascularization. Previous studies have established that thermal photocoagulation, the mainstay in the therapy of various neovascular diseases of the posterior segment, results in a decrease in intraocular concentrations of VEGF and other angiogenic growth factors, thereby inhibiting active retinal neovascularization. In the current study, we sought to determine whether thermal photocoagulation has the potential to regulate the expression of PEDF in human retinal pigment epithelial (RPE) cells. Cultures of RPE cells were photocoagulated with a 532-nm diode laser. Subsequently, RNA was isolated for RT-PCR, and whole-cell extracts and precipitated cell culture supernatant were subjected to Western blot analysis. According to our results, PEDF mRNA and protein are significantly upregulated after photocoagulation. Moreover, PEDF protein was found to be secreted in the cell culture medium.

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Section: Discussionmentioning

confidence: 99%

Pigment-Epithelium-Derived Factor Is Upregulated in Photocoagulated Human Retinal Pigment Epithelial Cells

et al. 2005

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“…Three smaller studies showed a short-term benefit in terms of drusen reduction from either argon or subthreshold diode laser. [119][120][121] Only one of these showed a benefit in terms of visual acuity. 120 One showed reduced CNV at eight years but included only 28 patients with substantial loss to follow-up.…”

Section: Laser Drusen Reductionmentioning

confidence: 99%

“…[119][120][121] Only one of these showed a benefit in terms of visual acuity. 120 One showed reduced CNV at eight years but included only 28 patients with substantial loss to follow-up. 121 Two larger studies using argon in a grid found increased CNV in some treatment groups.…”

Section: Laser Drusen Reductionmentioning

confidence: 99%

Treatment of age‐related macular degeneration

Bylsma

Guymer

2005

Clinical and Experimental Optometry

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Age-related macular degeneration (AMD) is the greatest cause of legal blindness in the western world. Established treatments include argon laser photocoagulation of extrafoveal choroidal neovascularisation (CNV) and photodynamic therapy of selected sub-foveal CNV. Newer approaches are targeting the angiogenic pathway in CNV development. Currently, other treatment modalities, such as radiotherapy and transpupillary thermotherapy do not have a clear role to play. Surgical options are experimental and only available in some centres for selected patients. Prevention of AMD remains elusive. Dietary supplements may have a role, while statins and prophylactic laser photocoagulation of drusen remain experimental. This paper explains the principles behind these approaches.

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“…127 The relationship between the IS-OS layer and retinal sensitivity has been reported in a variety of diseases. [128][129][130][131][132] Landa and colleagues demonstrated that retinal sensitivity was more influenced by IS-OS status than was best-corrected visual acuity (BCVA) in patients with AMD, suggesting that MP may be a more sensitive method than BCVA for following retinal function. 127 They also demonstrated that patients OCT/SLO MP is also able to detect a decrease in mean retinal sensitivity over areas of small drusen.…”

Section: Microperimetrymentioning

confidence: 99%

Scanning Laser Ophthalmoscope in the Management of Age-related Macular Degeneration

Scripsema¹,

Rosen²

2012

US Ophthalmic Review

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Recent advances in retinal imaging have improved the evaluation and prognostication of age-related macular degeneration. The development and modification of the scanning laser ophthalmoscope (SLO) has played a pivotal role in our understanding of the disease. SLO has led to improved methods of visualizing characteristics of the disease, such as drusen and alterations in autofluorescence, and also provided a platform for the quantification of structural and functional changes occurring as a result of the disease process. This article provides a review of the current literature on the impact and clinical utility of SLO devices for infrared viewing, fundus autofluorescence, microperimetry, and as integraded multimodal imaging systems such as optical coherence tomography and SLO.

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Argon laser vs. subthreshold infrared (810-nm) diode laser macular grid photocoagulation in nonexudative age-related macular degeneration

Cited by 20 publications

References 10 publications

Pigment-Epithelium-Derived Factor Is Upregulated in Photocoagulated Human Retinal Pigment Epithelial Cells

Pigment-Epithelium-Derived Factor Is Upregulated in Photocoagulated Human Retinal Pigment Epithelial Cells

Treatment of age‐related macular degeneration

Scanning Laser Ophthalmoscope in the Management of Age-related Macular Degeneration

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