Argon plasma coagulation of actinic keratoses imaged by optical coherence tomography: An in vivo study indicating a possible lesion‐directed treatment

Schmitz, Lutz; Hessam, Schapoor; Scholl, Lisa; Reitenbach, Sarah; Segert, Marc H.; Gambichler, Thilo; Stockfleth, Eggert; Bechara, Falk G.

doi:10.1002/jbio.201800075

Cited by 3 publications

(8 citation statements)

References 21 publications

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“…In this study we also aimed to investigate the effect of CAP on the HFUS parameters of both lesional and chronically photodamaged skin surrounding the lesions. To date, the biological effects of CAP on AKs have not been evaluated through non-invasive imaging techniques, with the exception of a study involving optical coherence tomography (OCT), which showed a clearly demarcated dermoepidermal junction and no residual epidermal tissue left in 74% lesions after CAP [ 32 ]. Notwithstanding, given the different resolution and penetration capabilities of OCT and HFUS, the results of our study are unlikely to be comparable to those obtained with OCT.…”

Section: Discussionmentioning

confidence: 99%

Cold Atmospheric Plasma (CAP) for the Treatment of Actinic Keratosis and Skin Field Cancerization: Clinical and High-Frequency Ultrasound Evaluation

Arisi

Soglia

Pisani

et al. 2021

Dermatol Ther (Heidelb)

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Introduction Cold atmospheric plasma (CAP) has been clinically demonstrated to be an effective treatment for actinic keratosis (AK) in a number of case series. In this study, we evaluated the efficacy of CAP in the treatment of multiple AKs and assessed morphological changes induced on the skin field of cancerization both clinically and by high-frequency ultrasound (HFUS). Methods Patients with multiple grade I–II AKs of the scalp and/or face who were resistant or intolerant to conventional field-directed treatments were enrolled. CAP treatments were performed using a microwave-driven argon plasma jet. At baseline and 3 months after the last CAP session, performance indexes were determined using three-dimensional digital pictures and HFUS investigations were performed on a representative Olsen grade II AK and a small spot of clinically unaffected skin within the test area. Results Twelve patients were enrolled in the study. All clinical variables showed a statistically significant reduction after CAP. HFUS evaluation revealed that the total, epidermal and dermal thicknesses of the target AKs had not changed with treatment. CAP therapy significantly increased dermal density in both the target AK and the surrounding photodamaged skin and signficantly decreased the thickness of the subepidermal low-echogenic band in the perilesional skin, which is an ultrasound sign of photodamage. Conclusions Cold atmospheric plasma was found to be an effective treatment for patients with multiple AKs. CAP was not followed by skin atrophy. HFUS examiniation showed the CAP improved features of chronic photodamage of the dermis of the skin underlying and surrounding the AK spots.

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Section: Discussionmentioning

confidence: 99%

Cold Atmospheric Plasma (CAP) for the Treatment of Actinic Keratosis and Skin Field Cancerization: Clinical and High-Frequency Ultrasound Evaluation

Arisi

Soglia

Pisani

et al. 2021

Dermatol Ther (Heidelb)

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“…It is estimated that an annual risk of an individual AK sun damage becoming a malignancy amounts to 0.025-16%. It is significantly higher in cases of numerous foci, especially when they cover the skin surface extensively [6].…”

Section: Wprowadzeniementioning

confidence: 98%

“…Szacuje się, że roczne ryzyko przemiany złośliwej pojedynczego ogniska AK wynosi 0,025-16%. Jest ono znacznie wyższe w przypadku występowania licznych zmian, zwłaszcza zajmujących rozległe powierzchnie skóry [6].…”

Section: Objectiveunclassified

“…Regular monitoring of patients, especially the ones from the risk group that includes older men with skin phototype 1 and 2, allows for early diagnosis and disease treatment [6].…”

Section: Omówieniementioning

confidence: 99%

“…Systematyczne monitorowanie pacjentów, zwłaszcza z grupy ryzyka, do której należą starsi mężczyźni z I i II fototypem skóry, umożliwia wcześniejsze rozpoznanie i leczenie choroby [6].…”

Section: Omówienieunclassified

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Application of photodynamic therapy with the use of superluminescent light-emitting diode (sLED) lamp in actinic keratosis

Bartosińska¹,

Gerkowicz²,

Niewiedzioł³

et al. 2019

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Introduction. Actinic keratosis is a chronic disease that often requires many treatment cycles. The choice of a treatment method depends on the thickness and number of lesions as well as their extent. An efficient method of treatment, especially in the case of superficial and moderately thick lesions, is photodynamic therapy. Objective. Assessment of the photodynamic therapy with the use of a superluminescent light-emitting diode lamp after previous application of 5-aminolevulinic acid based on the observations of selected cases of patients with actinic keratosis. Material and methods. The study included patients diagnosed with actinic keratosis. After debridement of scales and crusts from the affected skin area 16% 5-aminolevulinic acid cream was applied. The irradiation was performed with the use of the superluminescent light-emitting diode matrix illuminator Medlight that sent out pulsed red light. The clinical evaluation was carried out before, immediately after the procedure as well as after 1 and 3 weeks. Results. In one case, after many years of ineffective treatment with a cryosurgery, the treatment with application of superluminescent light-emitting diode therapy lead to disease remission. In the second case early therapy with the superluminescent light-emitting diode lamp lead to complete resolution of lesions. In the case of a patient with disseminated actinic keratosis, lesion-directed therapy was possible. Conclusions. Observation results indicate a beneficial effect of superluminescent light-emitting diodes and no recurrence of actinic keratosis lesions in 3 months after the procedure.

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Plasma catalytic ammonia synthesis: state of the art and future directions

Carreon

2019

J. Phys. D: Appl. Phys.

118

134

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This review describes the history and development of ammonia synthesis from its discovery to the early development of the Haber-Bosch process to the current use of plasma catalysis as an alternative to the possible process decentralization of this essential commodity. Proposed reaction mechanisms to-date for vacuum and atmospheric pressure discharges are summarized and discussed. The use of different discharges and materials employed as catalysts as well as the observed interactions between the plasma and the catalyst that can modify and activate the catalytic surface and the possible effects of the catalyst on plasma are herein summarized. Moreover, important differences between thermal catalysis and plasma catalysis are contrasted. It is intended that this review can also help to develop an understanding of the current knowledge and gaps for the ammonia synthesis through plasma catalysis with an emphasis on the challenges presently faced.

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Argon plasma coagulation of actinic keratoses imaged by optical coherence tomography: An in vivo study indicating a possible lesion‐directed treatment

Cited by 3 publications

References 21 publications

Cold Atmospheric Plasma (CAP) for the Treatment of Actinic Keratosis and Skin Field Cancerization: Clinical and High-Frequency Ultrasound Evaluation

Cold Atmospheric Plasma (CAP) for the Treatment of Actinic Keratosis and Skin Field Cancerization: Clinical and High-Frequency Ultrasound Evaluation

Application of photodynamic therapy with the use of superluminescent light-emitting diode (sLED) lamp in actinic keratosis

Plasma catalytic ammonia synthesis: state of the art and future directions

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