Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms

Egashira, Nobuaki; Okuno, Ryoko; Matsushita, Michihiko; Abe, Moe; Mishima, Kenichi; Iwasaki, Katsunori; Nishimura, Ryoji; Oishi, Ryozo; Fujiwara, Michihiro

doi:10.1016/j.ejphar.2008.06.100

Cited by 42 publications

(19 citation statements)

References 33 publications

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“…The antipsychotic aripiprazole antagonizes ethanoland amphetamine-induced locomotor stimulation in mice (50) and significantly suppresses locomotor activity in naïve animals as reported in a previous investigation (51) and this study. Moreover, other experimental results suggest the possible therapeutic application of aripiprazole to reduce the severity of morphine-induced adverse effects relating to dopaminergic neuronal activity such as morphine-induced hyperlocomotion and reward (52).…”

Section: Discussionmentioning

confidence: 50%

Effect of Aripiprazole on Anxiety Associated With Ethanol Physical Dependence and on Ethanol-Induced Place Preference

et al. 2012

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Abstract. In the present study, we investigated the effect of aripiprazole, a dopamine system stabilizer, on ethanol-induced psychological and physiological dependence and anxiety-like behavior. First we determined the effect of aripiprazole, a dopamine system stabilizer, on the development and expression of ethanol-induced place preference. Both the development and expression of ethanol-induced place preference was significantly suppressed by treatment of aripiprazole. Next, the withdrawal score gradually increased with increasing duration after the withdrawal from ethanol for 6 days in vehicle-treated mice and the maximal score was observed 10 h after the ethanol withdrawal. Aripiprazole caused no changes in the withdrawal score as compared to vehicletreated mice. Under these conditions we investigated the effect of aripiprazole on the anxiety-like behavior of ethanol physical dependent mice, which were animals subjected to ethanol vapor for 6 days. The significant decrease of time spent in the open arms and number of open arm entries characterize the anxiety-like behavior in ethanol physical dependent mice, compared to control mice. These decreases were reversed by treatment of aripiprazole, which were inhibited by WAY100635, a serotonin 5-HT 1A receptor antagonist. The present findings suggest that aripiprazole was efficient for reversing ethanol-induced place preference and anxiety-like behavior.

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Section: Discussionmentioning

confidence: 50%

Effect of Aripiprazole on Anxiety Associated With Ethanol Physical Dependence and on Ethanol-Induced Place Preference

et al. 2012

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“…More telling, SSRIs fail to reduce symptomology in 40-60% of OCD patients (Pallanti and Quercioli 2006), although benzodiazepines were even less effective (Goddard et al 2008). The clear implication is that OCD is a complex disorder that involves multiple systems rather the current emphasis on the serotonin receptor (Egashira et al 2008, Marazziti et al 2010, Takeuchi et al 2002.…”

Section: Discussionmentioning

confidence: 99%

Marble burying as compulsive behaviors in male and female mice

Taylor¹,

Lerch²,

Chourbaji³

2017

Acta Neurobiologiae Experimentalis

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Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive-compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA receptor or a "pure" inhibitor of the serotonin transporter, escitalopram, that has been reported to be particularly effective in OCD. A burying paradigm that more precisely mimics the human condition was used, e.g., testing in the home environment, chronic drug exposure and acknowledging individual differences by pre-selecting for high marble burying. Results were that there were no sex differences in groups treated with drugs or in control mice. Both diazepam and escitalopram decreased numbers of marbles buried compared to vehicle-only controls in the absence of correlated changes in anxiety. Diazepam, however, was more effective than escitalopram in suppressing MB. The conclusion is that along with serotonin, GABA is involved in regulating compulsive behaviors. The marble burying paradigm may prove more useful for pharmacological drugs tests of impulsivity or attention deficit because of the involvement of serotonin and GABA in both disorders.

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“…We decided to use doses within the medium to high range of those used in mammals (Niesink and Van Ree, 1982;Scotti de Carolis et al, 1986;Schechter, 1988;Hagan et al, 1997;Guscott et al, 2003;Morita et al, 2005;Freitas et al, 2006;Egashira et al, 2008).…”

Section: Effect Of Intraperitoneal Administration Of Pharmacological mentioning

confidence: 99%

Homeostasis of glucose in the rainbow trout (Oncorhynchus mykiss Walbaum): the role of serotonin

Tubío

Maceira

Aldegunde

2010

Journal of Experimental Biology

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Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms

Cited by 42 publications

References 33 publications

Effect of Aripiprazole on Anxiety Associated With Ethanol Physical Dependence and on Ethanol-Induced Place Preference

Effect of Aripiprazole on Anxiety Associated With Ethanol Physical Dependence and on Ethanol-Induced Place Preference

Marble burying as compulsive behaviors in male and female mice

Homeostasis of glucose in the rainbow trout (Oncorhynchus mykiss Walbaum): the role of serotonin

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