Aristolochic acid induces chronic kidney disease in ace knockout mice

Wu, Jiaping

doi:10.4103/ijpvm.ijpvm_344_19

Cited by 3 publications

(1 citation statement)

References 24 publications

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“… 35 – 37 Aristolochic acid and folic acid models are also widely used in AKI research field, which are particularly attractive for modeling the transition of AKI-to-CKD in mice because of their early fibrotic characteristics. 38 – 40 In humans, rhabdomyolysis often causes AKI because of intrinsic muscle dysfunction. Accordingly, intramuscular injection of glycerol in rodents is the well-established model of rhabdomyolysis AKI.…”

Section: Aki Modelsmentioning

confidence: 99%

Animal Models of Kidney Disease: Challenges and Perspectives

Liang

Liu

2023

Kidney360

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Kidney disease is highly prevalent and affects about 850 million people worldwide. It is also associated with high morbidity and mortality, and current therapies are incurable and often ineffective. Animal models are indispensable for understanding the pathophysiology of various kidney diseases and for preclinically testing novel remedies. In the last two decades, rodents continue to be the most used models for imitating human kidney diseases, largely due to the increasing availability of many unique genetically modified mice. Despite many limitations and pitfalls, animal models play an essential and irreplaceable role in gaining novel insights into the mechanisms, pathologies and therapeutic targets of kidney disease. In this review, we highlight commonly used animal models of kidney diseases by focusing on experimental acute kidney injury, chronic kidney disease, and diabetic kidney disease. We briefly summarize the pathological characteristics, advantages and drawbacks of some widely used models. Emerging animal models such as mini-pig, salamander, zebrafish and drosophila, as well as human-derived kidney organoids and kidney-on-a-chip are also discussed. Undoubtedly, careful selection and utilization of appropriate animal models is of vital importance in deciphering the mechanisms underlying nephropathies and evaluating the efficacy of new treatment options. Such studies will provide a solid foundation for future diagnosis, prevention and treatment of human kidney diseases.

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Section: Aki Modelsmentioning

confidence: 99%

Animal Models of Kidney Disease: Challenges and Perspectives

Liang

Liu

2023

Kidney360

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Nephrotoxicity of Natural Products: Aristolochic Acid and Fungal Toxins

Sotiropoulou,

Zielinski,

Dietrich

2024

Reference Module in Biomedical Sciences

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The Expression and Molecular Mechanisms of Matrix Metalloproteinase- 9 and Vascular Endothelial Growth Factor in Renal Interstitial Fibrosis in Rats

Lin,

Zhong

et al. 2024

CMM

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To explore a new approach for the treatment of renal interstitial fibrosis (RIF), we detected the expression of matrix metalloproteinase-9 (MMP9) and vascular endothelial growth factor (VEGF). Twenty-four male Sprague Dawley (SD) rats were randomly divided into 2-week normal control (2NC) group, 4-week NC (4NC) group, 2- week unilateral ureteral obstruction (2UUO) group, and 4-week UUO (4UUO) group. We performed left ureteral ligation on UUO groups. Then, we sacrificed the rats of the 2NC group and 2UUO group at 2 weeks and the other groups at 4 weeks after the surgery. Immunohistochemistry and western blot were applied to detect the expression of MMP9, VEGF, fibronectin (FN), type IV collagen (Col-IV), and transforming growth factor-β1 (TGF-β1). MMP9 levels reduced after UUO surgery. Its expression was less in the 4UUO group than in the 2UUO group (P<0.05). The expression of VEGF, TGF- β1, FN, and Col-IV was higher in UUO groups than in NC groups (P<0.05). The expression of these indicators was higher in the 4UUO group than in the 2UUO group (P<0.05). In the correlation analysis, MMP9 levels in UUO groups had a negative correlation with the expression of TGF-β1, VEGF, Col-IV, FN, and RIF index (all P<0.05). In UUO groups, VEGF levels had a positive correlation with the expression of TGF-β1, Col-IV, FN, and RIF index (all P<0.05). In conclusion, with the aggravation of RIF lesions, MMP9 levels decreased, and VEGF levels increased. Whether there is a mutual inhibition relationship between them remains to be confirmed by further experiments.

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Aristolochic acid induces chronic kidney disease in ace knockout mice

Cited by 3 publications

References 24 publications

Animal Models of Kidney Disease: Challenges and Perspectives

Animal Models of Kidney Disease: Challenges and Perspectives

Nephrotoxicity of Natural Products: Aristolochic Acid and Fungal Toxins

The Expression and Molecular Mechanisms of Matrix Metalloproteinase- 9 and Vascular Endothelial Growth Factor in Renal Interstitial Fibrosis in Rats

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