Let 𝐸∕ℚ be an elliptic curve with full rational 2torsion. As 𝑑 varies over squarefree integers, we study the behaviour of the quadratic twists 𝐸 𝑑 over a fixed quadratic extension 𝐾∕ℚ. We prove that for 100% of twists the dimension of the 2-Selmer group over 𝐾 is given by an explicit local formula, and use this to show that this dimension follows an Erdős-Kac type distribution. This is in stark contrast to the distribution of the dimension of the corresponding 2-Selmer groups over ℚ, and this discrepancy allows us to determine the distribution of the 2-torsion in the Shafarevich-Tate groups of the 𝐸 𝑑 over 𝐾 also. As a consequence of our methods we prove that, for 100% of twists 𝑑, the action of Gal(𝐾∕ℚ) on the 2-Selmer group of 𝐸 𝑑 over 𝐾 is trivial, and the Mordell-Weil group 𝐸 𝑑 (𝐾) splits integrally as a direct sum of its invariants and anti-invariants. On the other hand, we give examples of thin families of quadratic twists in which a positive proportion of the 2-Selmer groups over 𝐾 have non-trivial Gal(𝐾∕ℚ)-action, illustrating that these previous results are genuinely statistical phenomena.