Arm and Intensity-Matched Leg Exercise Induce Similar Inflammatory Responses

Leicht, Christof A.; Paulson, Thomas A.W.; Goosey-Tolfrey, Victoria L.; Bishop, Nicolette C.

doi:10.1249/mss.0000000000000874

Cited by 16 publications

(18 citation statements)

References 35 publications

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“…12). The present findings differed from Leicht and co-authors [39] in that increases in both monocyte subset numbers occurred immediately after exercise, whereas Leicht et al reported only a significant increase in CD14 + CD16 − monocytes but not CD14 + CD16 + monocytes, and only during a 2 h recovery from exercise. Significant changes were not detected immediately after exercise in their study.…”

Section: Concurrent Exercise Training Increased Circulating Monocyte contrasting

confidence: 99%

Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study

Goh

Hofmann

et al. 2020

transl med commun

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Background: Intense exercise is a systemic stressor associated with the release of "danger" moleculesalarmins, by damaged or dying cells into systemic circulation to evoke a sterile inflammatory response. Compared with research in clinical diseases, physiological responses of alarmins to exercise and training are not well studied. Shortterm responses to exercise and training using a panel of alarmins -HMGB1, S100A8/A9, HSP70 and sRAGE may reveal unique aspects of stress responses to strenuous exercise, with important ramifications when prescribing exercise to generally healthy adults. Methods: A 3-week, high-intensity training program was performed by healthy young men (N = 7). Concurrent aerobic and resistance exercises were performed on 3 consecutive days each week. Blood and saliva were collected before (Pre), immediately after (Post), and 30 min (30 min) after exercise each week, and 24 h after the final exercise session in week 3 (24 h). Results: Plasma HMGB1, S100A8/A9 and HSP70 increased from Pre to Post (P < 0.05), although at different timepoints during the study, and displayed different kinetics from IL-10, IL-8 and IFN-γ, suggesting unique mechanisms involved in modulating their release and clearance. CD14 + CD16 − monocytes increased from Pre to Post across 3 weeks; CD14 + CD16 + monocytes increased from Pre to Post in week 2 and 3 (P < 0.05). ΔHMGB1 and ΔHSP70 correlated positively with ΔMCP-1 during 3 weeks of training. As well, ΔHMGB1 correlated positively with CD14 + CD16 − monocytes, suggesting higher alarmin release after strenuous exercise may involve increase in circulating monocytes. Conclusions: Perturbations in systemic alarmins are novel biological signatures for assessing the inflammatory milieu of healthy adults during high-intensity exercise.

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Section: Concurrent Exercise Training Increased Circulating Monocyte contrasting

confidence: 99%

Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study

Goh

Hofmann

et al. 2020

transl med commun

View full text Add to dashboard Cite

show abstract

“…12). The present findings differed from Leicht and co-authors (39) in that increases in both monocyte subset numbers occurred immediately after exercise, whereas Leicht et al reported only a significant increase in CD14 + CD16monocytes but not CD14 + CD16 + monocytes, and only during a two hour recovery from exercise. Significant changes were not detected immediately after exercise in their study.…”

Section: Concurrent Exercise Training Increased Circulating Monocyte contrasting

confidence: 99%

Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study

Goh

Hofmann

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Intense exercise is a systemic stressor associated with the release of “danger” molecules – alarmins, by damaged or dying cells into systemic circulation to evoke a sterile inflammatory response. Compared with research in clinical diseases, physiological responses of alarmins to exercise and training are not well studied. Short-term responses to exercise and training using a panel of alarmins – HMGB1, S100A8/A9, HSP70 and sRAGE may reveal unique aspects of stress responses to strenuous exercise with important ramifications when prescribing exercise to generally healthy adults. Methods: A 3-week, high-intensity training program was performed by healthy young men (N = 7). Concurrent aerobic and resistance exercises were performed on 3 consecutive days each week. Blood and saliva were collected before (Pre), immediately after (Post), and 30 min (30 min) after exercise each week, and 24 h after the final exercise session in week 3 (24 h). Results: Plasma HMGB1, S100A8/A9 and HSP70 increased from Pre to Post (P < 0.05), although at different timepoints during the study, and displayed different kinetics from IL-10, IL-8 and IFN-γ, suggesting unique mechanisms involved in modulating their release and clearance. CD14+CD16- monocytes increased from Pre to Post across 3 weeks; CD14+CD16+ monocytes increased from Pre to Post in week 2 and 3 (P < 0.05). ΔHMGB1 and ΔHSP70 correlated positively with ΔMCP-1 during 3 weeks of training, while ΔHMGB1 correlated positively with CD14+CD16- monocytes, suggesting higher alarmin release after strenuous exercise may involve increase in circulating monocytes. Conclusions: Perturbations in systemic alarmins are novel biological signatures for assessing the inflammatory milieu of healthy adults during high-intensity exercise.

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“…While initially it was suggested that the limited muscle mass involved in arm exercise might be insufficient to provoke an inflammatory response (Hirose et al 2004; Bergfors et al 2005), recent studies have shown the elevation in plasma concentration ofIL-6 and IL-1ra after upper-body exercise ranging from 30 min at moderate intensity (Paulson et al 2015) to a wheelchair marathon (Sasaki et al 2014). Moreover, Leicht et al (2016) recently showed a similar acute inflammatory response to arm-compared to leg exercise when performed at the same relative intensity. Since the acute inflammatory response seems to be intensity and duration dependent, the initial lack of responses in IL-6 after upper-body exercise might have been caused by the short duration and the isolated muscle groups used for the exercise (Hirose et al 2004; Bergfors et al 2005).…”

Section: Discussionmentioning

confidence: 90%

Can intervals enhance the inflammatory response and enjoyment in upper-body exercise?

2017

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PurposeTo investigate the inflammatory and perceptual responses to three different forms of upper-body exercise.MethodsTwelve recreationally active, able-bodied males performed three work-matched arm-crank sessions in a randomised order: 30 min moderate-intensity continuous (CON), 30 min moderate-intensity with changes in cadence (CAD) and 20 min high-intensity interval training (HIIT). Blood samples were taken pre, post and 2-h post-exercise to determine plasma concentrations of interleukin (IL)-6 and IL-1ra. Perceptual responses pre, during and following the trials were assessed using the Feeling Scale, Felt Arousal Scale, Ratings of Perceived Exertion (RPE) and the Physical Activity Enjoyment Scale (PACES).ResultsAll trials were evenly effective in inducing an acute inflammatory response, indicated by similar increases in IL-6 after exercise and in IL-1ra at 2-h post exercise for all trials. More negative affect and higher RPE were reported during HIIT compared to CON and CAD, whereas PACES scores reported after exercise were higher for HIIT and CAD compared to CON.ConclusionsWhen matched for external work, there was no difference in the inflammatory response to HIIT compared to moderate-intensity upper-body exercise. Although HIIT was (perceived as) more strenuous and affective responses were more negative during this mode, the higher ratings of enjoyment for both HIIT and CAD reported after exercise suggest that the inclusion of variation enhances enjoyment in upper-body exercise. As the fashion in which upper-body exercise is performed does not seem to influence the inflammatory response, it might be advised to prescribe varied exercise to enhance its enjoyment.

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Arm and Intensity-Matched Leg Exercise Induce Similar Inflammatory Responses

Cited by 16 publications

References 35 publications

Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study

Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study

Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study

Can intervals enhance the inflammatory response and enjoyment in upper-body exercise?

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