Aroma of Eucommia leaf extract (ELE) causes reduced locomotor activity and increased NREM sleep, acting like the partially related factors of oral ELE's effects with locomotor-activity-dependent-increase in NREM- and REM-sleep

Chronic administration of Eucommia leaf extract (ELE) and asperuloside(ASP), the major component of ELE, prevents adipocyte hypertrophy in white adipose tissues

“…Obesity is characterized as hypertrophy and proliferation of adipocytes in white adipose tissue (WAT) [1,2]. Eucommia leaf extract (ELE) has been reported to have various bioactive properties [3][4][5][6][7][8][9][10][11], such as anti-obesity effects [6][7][8][9][10][11]. Asperuloside (ASP) is indicated as the major ingredient of ELE; it contributes to its anti-obesity effect [8,11].…”

The preventive effects of asperuloside administration on dextran sodium sulfate-induced ulcerative colitis in mice

“…However, mechanisms underlying the inhibition of histamine secretion from mast cells after asperuloside treatment are unknown. Asperuloside affects the central nervous system [18]; therefore, these results may be attributable to various neurological effects. AChRs (nicotinic receptors (nAChR) and mAChR) are expressed on the mast cells, and degranulation is induced when a ligand combines with these receptors.…”

Effect of Eucommia leaf extract on water consumption in rats is mediated by the parasympathetic nervous system

“…In recent years, the study of Eucommia leaf extract (ELE) has been focused on its efficacy in maintaining human health. Reports on the biogenic effectiveness of ELE ingestion have identified the following benefits: 1) antihyperlipidemic effects that reduce visceral fat and suppress elevated levels of triglyceride and cholesterol in the blood [1][2][3][4][5][6][7]; 2) effects on bone, such as preventing the onset of postmenopausal osteoporosis and promoting calcium accumulation in osteoblasts [8][9][10]; 3) antihypertensive effects that slowly decrease blood pressure by maintaining the flexibility of the blood vessels and promoting arterial smooth muscle relaxation [2,11]; 4) rapid eye movement sleep and non-rapid eye movement sleep inducing effect [12]; and 5) preventative effects on ulcerative colitis by asperuloside, one of the major components of ELE [13]. Thus, ELE promotes systemic health.…”