Aromatase expression in the eutopic endometrium of myomatous uteri: The influence of the menstrual cycle and oral contraceptive use

Maia, Hugo; Pimentel, Kleber; Casoy, Julio; Correia, Thiago Macêdo Lopes; Freitas, Luis; Zausner, Bela; Athayde, Célia

doi:10.1080/09513590701321565

Cited by 19 publications

(11 citation statements)

References 22 publications

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“…The hormonal and inflammatory factors that regulate aromatase expression in the endometrium are therefore important for the survival of endometrial cells in the peritoneal cavity, their subsequent implantation and the formation of endometriotic lesions [5]. In patients with myomas, aromatase expression in the endometrium is lower during the luteal phase, thus suggesting an inhibitory effect of progesterone [6]. Similarly in peripheral macrophages, aromatase expression was also found to diminish significantly during the luteal phase compared with the other phases of the menstrual cycle [7].…”

Section: Introductionmentioning

confidence: 99%

The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis

Maia¹,

Casoy²,

Correia

et al. 2008

Gynecological Endocrinology

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Section: Introductionmentioning

confidence: 99%

The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis

Maia¹,

Casoy²,

Correia

et al. 2008

Gynecological Endocrinology

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“…COX-2, which converts arachidonic acid into prostaglandin H 2 (precursor of all prostaglandins [PGs] and thromboxanes), represents a mitogen-induced form of cyclooxygenase, manifesting expression in response to various inflammatory stimuli including IL-1b and TNF-a. In myometrium and endometrium estrogens stimulate COX-2 to synthesize PGE 2 [13]. The PGE 2 is associated with proinflammatory mechanisms and could enhance the function of NFkB, whereas the PGA 1, PGA 2 and PGJ 2 are associated with suppression of inflammation and are able to inhibit NF-kB activation [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages

Plewka

Madej

Plewka

et al. 2013

Folia Histochem Cytobiol.

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Uterine myomas represent one of the most frequently manifested benign tumors in women. They originate from smooth muscle cells of myometrium or its blood vessels. Many studies suggest that inflammation and pro-inflammatory factors may play a role in the carcinogenesis with an involvement of the transcription factor NF-kB which activity can be controlled by various environmental factors, including many cytokines. The aim of the study was to investigate the expression of NF-B, interleukin-1b (IL-1b), tumor necrosis factor a (TNF-a), cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) in myometrium and uterine myomas of women of various age. The expression of NF-kB, selected cytokines and enzymes was estimated in women of reproductive or perimenopausal age by semiquantitative immunohistochemistry. The expression of the examined proteins was higher in myomas than in control myometrium and was dependent on the size of myomas and the age of women. However, the expression of the cytoplasmic NF-kB observed in uterine myomas was independent on the size of myomas and no significant differences were observed in the number of stained nuclei between control and myoma groups. Thus, the expression of proinflammatory factors in myomas was not accompanied by the nuclear activation of NF-kB p65. The results of our study indicate that the examined factors may be involved in the pathogenesis of benign tumors and not only malignant diseases.

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“…Estrogens stimulate COX-2 to synthesize PGE2 in myometrium. 37 PGE2 is known to enhance activation of NF-kB and the production of proinflammatory cytokines. On the other hand, PGA1, PGA2, and PGJ2 are associated with the suppression of inflammation and are able to inhibit NF-kB activation.…”

Section: Estrogen and Myometrium Immunitymentioning

confidence: 99%

Uterine Fibroids: Bridging Genomic Defects and Chronic Inflammation

et al. 2017

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Uterine fibroids (UF; aka leiomyoma, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70 to 80% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pelvic bulk symptoms, miscarriage, and infertility. They are the leading indication for hysterectomy, and costs exceed 34 billion dollars annually in the United States alone. Recently, somatic mutations in exons 1 and 2 of Med12 gene emerged as common UF driver mutations. Unfortunately, the detailed etiology of UF is not fully realized. Particularly, very little is known about possible dysregulation of inflammatory and immune processes and their possible contribution to UF pathogenesis. The notion on possible impact of altered estrogen and progesterone signaling in UF on inflammatory responses and DNA repair machinery that can conceivably lead to tumor-specific somatic mutation is indeed an intriguing concept which has some foundation in available observation in other hormonally responsive tissues. This review highlights and summarizes our current knowledge on the convergence of such pathways and their relevance for UF pathogenesis.

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Aromatase expression in the eutopic endometrium of myomatous uteri: The influence of the menstrual cycle and oral contraceptive use

Abstract: Aromatase expression in the endometrium was affected by the location of the myoma, the presence of symptoms, and the phase of the menstrual cycle. Oral contraceptives, on the other hand, inhibited aromatase expression in the eutopic endometrium of patients with submucous/intramural myomas.

Cited by 19 publications

References 22 publications

The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis

The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis

Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages

Uterine Fibroids: Bridging Genomic Defects and Chronic Inflammation

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